{"id":"https://openalex.org/W2094853564","doi":"https://doi.org/10.1097/00000542-199605000-00006","title":"Enzymatic Versus Pharmacologic Antagonism of Profound Mivacurium-induced Neuromuscular Blockade","display_name":"Enzymatic Versus Pharmacologic Antagonism of Profound Mivacurium-induced Neuromuscular Blockade","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2094853564","doi":"https://doi.org/10.1097/00000542-199605000-00006","mag":"2094853564","pmid":"https://pubmed.ncbi.nlm.nih.gov/8623998"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-199605000-00006","doi":"https://doi.org/10.1097/00000542-199605000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-199605000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102991475","display_name":"Mohamed Naguib","orcid":"https://orcid.org/0000-0002-5417-8168","observed_orcids":["https://orcid.org/0000-0002-5417-8168"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I4210138988","display_name":"King Khalid University Hospital","ror":"https://ror.org/046gga527","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210138988"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed Naguib","raw_affiliation_strings":["Department of Anaesthesiology, King Saud University, Faculty of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, King Saud University, Faculty of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161","https://openalex.org/I4210138988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057877818","display_name":"Mahdi Selim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahdi Selim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077306515","display_name":"Hassan Bakhamees","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan S. Bakhamees","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000032580","display_name":"Abdulhamid H. Samarkandi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdulhamid H. Samarkandi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109980297","display_name":"Ahmed Turkistani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed Turkistani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9034,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.75191638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"84","issue":"5","first_page":"1051","last_page":"1059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mivacurium","display_name":"mivacurium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuromuscular-blockade","display_name":"neuromuscular blockade","score":0.8799999952316284},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/edrophonium","display_name":"edrophonium","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neostigmine","display_name":"neostigmine","score":1.0},{"id":"https://openalex.org/keywords/neuromuscular-blockade-reversal","display_name":"neuromuscular blockade reversal","score":0.6570000052452087},{"id":"https://openalex.org/keywords/train-of-four","display_name":"train-of-four","score":0.828000009059906},{"id":"https://openalex.org/keywords/adductor-pollicis","display_name":"adductor pollicis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/neuromuscular-monitoring","display_name":"neuromuscular monitoring","score":0.6320000290870667},{"id":"https://openalex.org/keywords/nondepolarizing-muscle-relaxants","display_name":"nondepolarizing muscle relaxants","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neuromuscular-recovery","display_name":"neuromuscular recovery","score":0.4569999873638153},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8320573568344116},{"id":"https://openalex.org/C2779101902","wikidata":"https://www.wikidata.org/wiki/Q22679015","display_name":"Butyrylcholinesterase","level":5,"score":0.8017628192901611},{"id":"https://openalex.org/C2777411258","wikidata":"https://www.wikidata.org/wiki/Q410546","display_name":"Neostigmine","level":2,"score":0.7863648533821106},{"id":"https://openalex.org/C2781448737","wikidata":"https://www.wikidata.org/wiki/Q3177745","display_name":"Edrophonium","level":3,"score":0.7812634706497192},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7391033172607422},{"id":"https://openalex.org/C3020341438","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular transmission","level":2,"score":0.7058761119842529},{"id":"https://openalex.org/C2909465803","wikidata":"https://www.wikidata.org/wiki/Q3286619","display_name":"Neuromuscular Blockade","level":2,"score":0.6477875113487244},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.6039505004882812},{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.5945276021957397},{"id":"https://openalex.org/C206044474","wikidata":"https://www.wikidata.org/wiki/Q1723956","display_name":"Neuromuscular monitoring","level":3,"score":0.5933327078819275},{"id":"https://openalex.org/C2776860028","wikidata":"https://www.wikidata.org/wiki/Q1225289","display_name":"Muscle relaxant","level":2,"score":0.5857330560684204},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.563978374004364},{"id":"https://openalex.org/C2776184885","wikidata":"https://www.wikidata.org/wiki/Q27108523","display_name":"Vecuronium bromide","level":2,"score":0.4619482159614563},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4553568363189697},{"id":"https://openalex.org/C42533223","wikidata":"https://www.wikidata.org/wiki/Q1378064","display_name":"ED50","level":3,"score":0.42408493161201477},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.24822905659675598},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.23087218403816223},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2191775143146515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09223026037216187},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08009913563728333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06266075372695923},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077590","descriptor_name":"Mivacurium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003473","descriptor_name":"Neuromuscular Nondepolarizing Agents","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004491","descriptor_name":"Edrophonium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009388","descriptor_name":"Neostigmine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-199605000-00006","doi":"https://doi.org/10.1097/00000542-199605000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-199605000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:8623998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8623998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1994156988","https://openalex.org/W1997085635","https://openalex.org/W2008474649","https://openalex.org/W2012538045","https://openalex.org/W2015208085","https://openalex.org/W2016632851","https://openalex.org/W2031226928","https://openalex.org/W2041993978","https://openalex.org/W2055145723","https://openalex.org/W2058874590","https://openalex.org/W2068767408","https://openalex.org/W2074170031","https://openalex.org/W2076640524","https://openalex.org/W2085426313","https://openalex.org/W2088748706","https://openalex.org/W2088922362","https://openalex.org/W2090909424","https://openalex.org/W2099103154","https://openalex.org/W2100314055","https://openalex.org/W2109669779","https://openalex.org/W2120480918","https://openalex.org/W2133272609","https://openalex.org/W2149194068","https://openalex.org/W2339906229"],"related_works":["https://openalex.org/W48403092","https://openalex.org/W4254136406","https://openalex.org/W2083597237","https://openalex.org/W2074170031","https://openalex.org/W1995290487","https://openalex.org/W2905232222","https://openalex.org/W428875696","https://openalex.org/W2144360893","https://openalex.org/W2802794891","https://openalex.org/W2330326567"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mivacurium,":[1],"a":[2,58,159,344],"nondepolarizing":[3],"muscle":[4],"relaxant,":[5],"is":[6],"hydrolyzed":[7],"by":[8,101],"butyrylcholinesterase.":[9],"The":[10,170,207],"use":[11],"of":[12,16,29,61,106,153,161,193,230,252,267,311,339,357,359],"butyrylcholinesterase":[13,301,317],"for":[14],"antagonism":[15,251],"profound":[17,46,62,254,374],"mivacurium-induced":[18,47,63,253,375],"blockade":[19,64],"has":[20],"not":[21],"been":[22],"studied":[23],"in":[24,116,121,142,184,191,221,228,272,306,337,370],"humans.":[25],"In":[26,49,132,247],"part":[27,50,133,248],"1":[28,76,123,291],"this":[30],"two-part":[31],"study,":[32],"the":[33,36,39,103,107,125,128,154,162,176,213,250,321],"authors":[34],"examined":[35],"relationship":[37,172,209,346],"between":[38,173,210,353],"posttetanic":[40],"count":[41],"(PTC)":[42],"and":[43,112,175,188,212,225,262,278,287,296,355],"recovery":[44,340],"from":[45,323],"blockade.":[48,377],"2,":[51,249],"an":[52],"attempt":[53],"was":[54,99,127,137,182,196,219,233,343],"made":[55],"to":[56,94,110,139,179,198,216,235,303,327,332,365,372],"antagonize":[57,373],"quantified":[59],"level":[60],"using":[65],"either":[66],"butyrylcholinesterase,":[67],"edrophonium,":[68],"or":[69,77,257,308],"neostigmine.":[70],"METHODS:":[71],"Eighty-seven":[72],"ASA":[73],"physical":[74],"status":[75],"2":[78],"adult":[79],"patients":[80,118,144,195,232],"were":[81,91,270],"given":[82],"0.15":[83],"mg.kg-1":[84,283],"mivacurium":[85],"during":[86],"fentanyl-thiopental-nitrous":[87],"oxide-isoflurane":[88],"anesthesia.":[89],"They":[90],"randomly":[92],"assigned":[93],"eight":[95],"groups.":[96],"Neuromuscular":[97],"function":[98,136,190,227],"monitored":[100],"recording":[102],"mechanomyographic":[104],"response":[105,157,165,326],"adductor":[108],"pollicis":[109],"PTC":[111,174,211,325,354],"train-of-four":[113],"(TOF)":[114],"stimulation":[115,181,218],"all":[117],"except":[119],"those":[120],"group":[122,333],"where":[124],"TOF":[126,149,180,202,217,239,328,360],"only":[129],"pattern":[130],"used.":[131],"1,":[134],"neuromuscular":[135,189,226,376],"allowed":[138,197,234],"recover":[140,199,236],"spontaneously":[141,200],"ten":[143],"(group":[145,244],"1;":[146,259],"control-TOF)":[147],"until":[148,201,238],"ratio":[150,203,240],"(the":[151],"amplitude":[152],"fourth":[155],"evoked":[156,164],"as":[158],"fraction":[160],"first":[163,177,214,324],"T4/T1)":[166],"had":[167,204,241],"reached":[168,205,242],"0.75.":[169,206],"temporal":[171,208],"reaction":[178,215],"determined":[183,220],"another":[185,222,273],"31":[186],"patients,":[187,224],"10":[192,229],"these":[194,231],"21":[223],"spontaneously,":[237],"0.75":[243,330],"2;":[245],"control-PTC).":[246],"(PTC":[255],">":[256],"=":[258,329,348,351],"groups":[260,285],"3-6)":[261],"90%":[263],"block":[264],"(groups":[265],"7-8)":[266],"twitch":[268],"height":[269],"investigated":[271],"56":[274],"patients.":[275],"Groups":[276,294],"3":[277],"7":[279],"received":[280,289,298],"neostigmine":[281],"0.06":[282],"whereas":[284],"4":[286],"8":[288],"edrophonium":[290,319],"mg.kg-1,":[292],"respectively.":[293,314],"5":[295],"6":[297],"exogenous":[299],"human":[300,312],"equivalent":[302],"activity":[304],"present":[305],"25":[307],"70":[309],"ml.kg-1":[310],"plasma,":[313],"RESULTS:":[315],"Neither":[316],"nor":[318],"shortened":[320],"times":[322],"compared":[331],"2.":[334],"Neostigmine":[335],"resulted":[336],"prolongation":[338],"time.":[341],"There":[342,363],"linear":[345],"(r":[347],"-0.80;":[349],"P":[350],"0.00001)":[352],"time":[356],"onset":[358],"response.":[361],"CONCLUSIONS:":[362],"appears":[364],"be":[366],"no":[367],"clinical":[368],"advantage":[369],"attempting":[371]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
