{"id":"https://openalex.org/W2094828555","doi":"https://doi.org/10.1097/01.mpa.0000297675.00450.c0","title":"CROSS-PLATFORM MOLECULAR PROFILING OF CELLULAR PATHWAYS INVOLVED IN PANCREATIC CANCER","display_name":"CROSS-PLATFORM MOLECULAR PROFILING OF CELLULAR PATHWAYS INVOLVED IN PANCREATIC CANCER","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2094828555","doi":"https://doi.org/10.1097/01.mpa.0000297675.00450.c0","mag":"2094828555"},"language":"en","primary_location":{"id":"doi:10.1097/01.mpa.0000297675.00450.c0","doi":"https://doi.org/10.1097/01.mpa.0000297675.00450.c0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000297675.00450.c0","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100673213","display_name":"Jennifer L. Carter","orcid":"https://orcid.org/0000-0002-5298-4844","observed_orcids":["https://orcid.org/0000-0002-5298-4844"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Carter","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028009560","display_name":"Craig D. Logsdon","orcid":"https://orcid.org/0000-0002-2214-1491","observed_orcids":["https://orcid.org/0000-0002-2214-1491"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Logsdon","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022922397","display_name":"M. Fazier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Fazier","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056275367","display_name":"Ann McNeill Killary","orcid":"https://orcid.org/0000-0002-9250-0832","observed_orcids":["https://orcid.org/0000-0002-9250-0832"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Killary","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039200530","display_name":"Subrata Sen","orcid":"https://orcid.org/0000-0001-6884-6246","observed_orcids":["https://orcid.org/0000-0001-6884-6246"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Sen","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22192876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4","first_page":"395","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-biomarkers","display_name":"early biomarkers","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7099999785423279},{"id":"https://openalex.org/keywords/s100-family","display_name":"S100 family","score":0.7540000081062317},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/genome-copy-number","display_name":"genome copy number","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cross-platform-validation","display_name":"cross-platform validation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.609000027179718},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.6119999885559082},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.6850000023841858},{"id":"https://openalex.org/keywords/inflammatory-carcinogenesis","display_name":"inflammatory carcinogenesis","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.9012205004692078},{"id":"https://openalex.org/C2781005279","wikidata":"https://www.wikidata.org/wiki/Q5264825","display_name":"Desmoplasia","level":4,"score":0.6298511028289795},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5962175726890564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5567549467086792},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5030807852745056},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4990410804748535},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.47749564051628113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45872682332992554},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.455535888671875},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4480946660041809},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.43620264530181885},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.434331476688385},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4242701232433319},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32024702429771423},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31163081526756287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.293651282787323},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2719038724899292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18835154175758362},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15573236346244812}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.mpa.0000297675.00450.c0","doi":"https://doi.org/10.1097/01.mpa.0000297675.00450.c0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000297675.00450.c0","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152393478","https://openalex.org/W1982162547","https://openalex.org/W96091098","https://openalex.org/W2120014725","https://openalex.org/W2465854971","https://openalex.org/W2054302145","https://openalex.org/W2100018617","https://openalex.org/W1974749747","https://openalex.org/W4223617243","https://openalex.org/W2021009598"],"abstract_inverted_index":{"Although":[0],"pancreatic":[1,41,53,195,225,240],"cancer":[2,9,54,140,196,241],"is":[3,222],"the":[4,12,18,29,38,131,177,180,208,213,231],"fourth":[5],"leading":[6],"cause":[7],"of":[8,66,134,147,169,179,215,224,237],"deaths":[10],"in":[11,21,31,51,77,94,96,99,115,139,212,217,239],"United":[13],"States,":[14],"efforts":[15],"to":[16,28,46,175,192,202,206],"identify":[17,47],"early":[19,33,52,60],"events":[20],"tumor":[22,85],"progression":[23,55,141],"have":[24],"proven":[25],"challenging":[26],"due":[27],"difficulty":[30],"detecting":[32],"disease":[34],"as":[35,37,56,58,81,83,118,120,154,197,199],"well":[36,57,82,119,198],"desmoplasia":[39],"accompanying":[40],"cancer.":[42,226],"In":[43],"an":[44,218],"effort":[45],"target":[48],"pathways":[49,117,124,185,209,238],"involved":[50,211],"potential":[59,137,252],"biomarkers":[61],"for":[62,113],"detection,":[63],"molecular":[64],"profiling":[65],"both":[67,95],"gene":[68,162],"expression":[69,163],"and":[70,98,125,146,183,194],"genomic":[71],"copy":[72],"number":[73],"was":[74,130,172],"performed":[75],"on":[76,251],"vitro":[78,97],"cell":[79],"lines":[80],"patient":[84],"samples":[86,101,168],"using":[87,109],"multiple":[88,123,149],"microarray":[89],"platforms.":[90],"This":[91],"cross-validation":[92],"approach":[93],"vivo":[100],"identified":[102,153],"common":[103,191],"candidate":[104,181],"genes":[105,182],"that":[106,221,233],"were":[107,152,190,204],"examined":[108,205],"pathway":[110],"analysis":[111],"software":[112],"involvement":[114],"cellular":[116,184],"interactions":[121],"between":[122,164],"networks.":[126],"Of":[127],"particular":[128],"interest":[129],"S100":[132],"family":[133,150],"molecules,":[135],"whose":[136],"roles":[138],"has":[142],"recently":[143],"been":[144],"noted,":[145],"which":[148,160,189],"members":[151],"candidates.":[155],"An":[156],"independent":[157],"data":[158],"set":[159],"included":[161],"adenocarcinoma,":[165],"normal":[166],"pancreas,":[167],"chronic":[170],"pancreatitis":[171,193],"then":[173],"used":[174],"analyze":[176],"profile":[178],"identified.":[186],"Those":[187],"profiles,":[188],"those":[200],"unique":[201],"either":[203],"specify":[207],"potentially":[210],"development":[214],"malignancy":[216],"inflammatory":[219],"background":[220],"typical":[223],"These":[227],"preliminary":[228],"findings":[229],"support":[230],"concept":[232],"cross":[234],"platform":[235],"analyses":[236],"from":[242],"a":[243],"systems":[244],"biology":[245],"perspective":[246],"can":[247],"yield":[248],"novel":[249],"information":[250],"pathogenetic":[253],"mechanisms":[254],"underlying":[255],"this":[256],"disease.":[257]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}