{"id":"https://openalex.org/W2094565495","doi":"https://doi.org/10.1074/jbc.m110.123794","title":"LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis","display_name":"LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2094565495","doi":"https://doi.org/10.1074/jbc.m110.123794","mag":"2094565495","pmid":"https://pubmed.ncbi.nlm.nih.gov/20489196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903404"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.123794","doi":"https://doi.org/10.1074/jbc.m110.123794","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.123794","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m110.123794","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059306205","display_name":"Koji Ohashi","orcid":"https://orcid.org/0000-0002-9666-026X","observed_orcids":["https://orcid.org/0000-0002-9666-026X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koji Ohashi","raw_affiliation_strings":["Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041987541","display_name":"Noriyuki Ouchi","orcid":"https://orcid.org/0009-0003-8598-3498","observed_orcids":["https://orcid.org/0009-0003-8598-3498"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noriyuki Ouchi","raw_affiliation_strings":["From the Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113508308","display_name":"Akiko Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akiko Higuchi","raw_affiliation_strings":["From the Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061151936","display_name":"Reuben J. Shaw","orcid":"https://orcid.org/0000-0002-1555-8977","observed_orcids":["https://orcid.org/0000-0002-1555-8977"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reuben J. Shaw","raw_affiliation_strings":["the Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060967318","display_name":"Kenneth Walsh","orcid":"https://orcid.org/0000-0001-7580-2276","observed_orcids":["https://orcid.org/0000-0001-7580-2276"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth Walsh","raw_affiliation_strings":["From the Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 and","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060967318"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4319,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.80165596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"285","issue":"29","first_page":"22291","last_page":"22298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ampk-phosphorylation","display_name":"AMPK phosphorylation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/ischemia-induced-angiogenesis","display_name":"ischemia-induced angiogenesis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/revascularization","display_name":"revascularization","score":0.7609999775886536},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tie2-cre","display_name":"Tie2-Cre","score":0.625},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6840000152587891},{"id":"https://openalex.org/keywords/endothelial-network-formation","display_name":"endothelial network formation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/hindlimb-ischemia","display_name":"hindlimb ischemia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.7322901487350464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6209722757339478},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6168082356452942},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.5627498626708984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5434290766716003},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5266304612159729},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.505836009979248},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4015129506587982},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38371190428733826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34513866901397705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32025760412216187}],"mesh":[{"descriptor_ui":"D000091162","descriptor_name":"AMP-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042787","descriptor_name":"Receptor, TIE-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m110.123794","doi":"https://doi.org/10.1074/jbc.m110.123794","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.123794","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2903404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2903404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20489196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20489196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.123794","doi":"https://doi.org/10.1074/jbc.m110.123794","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.123794","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1066430131","display_name":null,"funder_award_id":"HL81587","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1124087647","display_name":"REGULATION OF VESSEL WALL APOPTOSIS","funder_award_id":"R01AG015052","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1343206284","display_name":"Mechanisms of Angiogenesis","funder_award_id":"R01HL091949","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1566545912","display_name":"REGULATION OF VESSEL WALL APOPTOSIS","funder_award_id":"R37AG015052","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2840044371","display_name":null,"funder_award_id":"AG15052","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G438006702","display_name":"Metabolic Control of Endothelias Cell Phenotype","funder_award_id":"P01HL081587","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8012341023","display_name":null,"funder_award_id":"HL91949","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1619256199","https://openalex.org/W1970017835","https://openalex.org/W1971837252","https://openalex.org/W1973262582","https://openalex.org/W1975755652","https://openalex.org/W1990840335","https://openalex.org/W1998710183","https://openalex.org/W2001832472","https://openalex.org/W2008967025","https://openalex.org/W2009616259","https://openalex.org/W2010238890","https://openalex.org/W2014782980","https://openalex.org/W2021549989","https://openalex.org/W2027589607","https://openalex.org/W2031565825","https://openalex.org/W2032607892","https://openalex.org/W2039167216","https://openalex.org/W2040986717","https://openalex.org/W2047392757","https://openalex.org/W2049943977","https://openalex.org/W2052498320","https://openalex.org/W2061500368","https://openalex.org/W2068820862","https://openalex.org/W2070475419","https://openalex.org/W2082472130","https://openalex.org/W2085076473","https://openalex.org/W2102989037","https://openalex.org/W2105786692","https://openalex.org/W2109340122","https://openalex.org/W2119711962","https://openalex.org/W2123558789","https://openalex.org/W2125039061","https://openalex.org/W2132708041","https://openalex.org/W2137662644","https://openalex.org/W2138319716","https://openalex.org/W2142072453","https://openalex.org/W2143690341","https://openalex.org/W2143950284","https://openalex.org/W2155180999","https://openalex.org/W2163993647","https://openalex.org/W2168438265"],"related_works":["https://openalex.org/W4395061000","https://openalex.org/W2021549989","https://openalex.org/W332994672","https://openalex.org/W2148072839","https://openalex.org/W2884767572","https://openalex.org/W2603221461","https://openalex.org/W2012240256","https://openalex.org/W1540515957","https://openalex.org/W2113278438","https://openalex.org/W2115891886"],"abstract_inverted_index":{"LKB1":[0,19,44,61,69,113,129,153],"is":[1,20,32,46,203],"a":[2,13,186,204],"tumor":[3],"suppressor":[4],"protein":[5,22,27],"whose":[6],"loss":[7],"leads":[8],"to":[9,38,71,211],"HIF1alpha-mediated":[10],"activation":[11],"of":[12,25,68,92,112,171,185,190,207],"proangiogenic":[14],"program":[15],"in":[16,55,62,114,200],"intestinal":[17],"polyps.":[18],"also":[21],"kinase":[23,28],"regulator":[24,206],"AMP-activated":[26],"(AMPK)":[29],"signaling,":[30],"which":[31],"essential":[33],"for":[34,60],"endothelial":[35,116,132,172,201],"cell":[36],"responses":[37],"tissue":[39,212],"ischemia.":[40,213],"To":[41],"discern":[42],"whether":[43],"signaling":[45,198],"either":[47,119],"pro-":[48],"or":[49,123],"antiangiogenic,":[50],"we":[51],"investigated":[52],"ischemia-induced":[53],"revascularization":[54,91,209],"mice":[56,78,84],"that":[57,142,195],"were":[58,79],"deficient":[59],"Tie2-Cre-expressing":[63],"cells.":[64],"Whereas":[65],"homozygous":[66],"deletion":[67],"led":[70],"embryonic":[72],"lethality,":[73],"heterozygous":[74,82],"LKB1-knock-out":[75],"(KO)":[76],"(Lkb1(flox/+);Tie2(Tg/+))":[77],"viable.":[80],"Unchallenged":[81],"LKB1-KO":[83],"displayed":[85],"normal":[86],"capillary":[87,108],"density,":[88],"but":[89],"the":[90,183,196,208],"hind":[93],"limb":[94],"following":[95],"ischemic":[96],"surgery":[97],"was":[98,143,162,180],"significantly":[99],"impaired":[100],"as":[101],"evaluated":[102],"by":[103,145,178,182],"laser":[104],"Doppler":[105],"flow":[106],"and":[107,135,160],"density":[109],"measurements.":[110],"Reduction":[111],"cultured":[115],"cells,":[117],"using":[118],"small":[120],"interfering":[121],"RNA":[122],"an":[124],"adenovirus":[125],"expressing":[126],"nonfunctional":[127],"kinase-dead":[128],"protein,":[130],"attenuated":[131],"proliferation,":[133],"migration,":[134],"differentiation":[136,170],"into":[137,174],"network":[138,157,175],"structures":[139,176],"on":[140],"Matrigel":[141],"accompanied":[144],"diminished":[146],"AMPK":[147,166],"phosphorylation":[148],"at":[149],"Thr-172.":[150],"Conversely,":[151],"adenovirus-mediated":[152],"overexpression":[154],"(Ad-LKB1)":[155],"augmented":[156,169],"structure":[158],"formation,":[159],"this":[161],"associated":[163],"with":[164],"elevated":[165],"phosphorylation.":[167],"The":[168],"cells":[173,202],"induced":[177],"Ad-LKB1":[179],"abrogated":[181],"co-transduction":[184],"dominant":[187],"negative":[188],"mutant":[189],"AMPK.":[191],"These":[192],"observations":[193],"suggest":[194],"LKB1-AMPK":[197],"axis":[199],"positive":[205],"response":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}