{"id":"https://openalex.org/W2094564855","doi":"https://doi.org/10.1006/exnr.2000.7461","title":"Neurofilament-Rich Intraneuronal Inclusions Exacerbate Neurodegenerative Sequelae of Brain Trauma in NFH/LacZ Transgenic Mice","display_name":"Neurofilament-Rich Intraneuronal Inclusions Exacerbate Neurodegenerative Sequelae of Brain Trauma in NFH/LacZ Transgenic Mice","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2094564855","doi":"https://doi.org/10.1006/exnr.2000.7461","mag":"2094564855","pmid":"https://pubmed.ncbi.nlm.nih.gov/10964487"},"language":"en","primary_location":{"id":"doi:10.1006/exnr.2000.7461","doi":"https://doi.org/10.1006/exnr.2000.7461","is_oa":true,"landing_page_url":"https://doi.org/10.1006/exnr.2000.7461","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/exnr.2000.7461","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084326649","display_name":"James E. Galvin","orcid":"https://orcid.org/0000-0002-4561-0318","observed_orcids":["https://orcid.org/0000-0002-4561-0318"]},"institutions":[{"id":"https://openalex.org/I2803028891","display_name":"Hahnemann University Hospital","ror":"https://ror.org/016bbv872","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803028891"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Galvin","raw_affiliation_strings":["Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA","Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2803028891"]},{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2803028891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079564982","display_name":"Michio Nakamura","orcid":"https://orcid.org/0000-0002-6606-1872","observed_orcids":["https://orcid.org/0000-0002-6606-1872"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michio Nakamura","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010152737","display_name":"Tracy K. McIntosh","orcid":"https://orcid.org/0000-0002-8612-6725","observed_orcids":["https://orcid.org/0000-0002-8612-6725"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy K. McIntosh","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113827767","display_name":"Kathryn E. Saatman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn E. Saatman","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028735637","display_name":"Deepak M. Sampathu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Sampathu","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061860555","display_name":"Ramesh Raghupathi","orcid":"https://orcid.org/0000-0001-9572-0657","observed_orcids":["https://orcid.org/0000-0001-9572-0657"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Raghupathi","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M.-Y. Lee","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Q. Trojanowski","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":{"value":4110,"currency":"USD","value_usd":4110},"fwci":1.9998,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.86145665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"165","issue":"1","first_page":"77","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.16529999673366547,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofilaments","display_name":"neurofilaments","score":0.6949999928474426},{"id":"https://openalex.org/keywords/intraneuronal-inclusions","display_name":"intraneuronal inclusions","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuronal-cytoplasmic-inclusions","display_name":"neuronal cytoplasmic inclusions","score":0.8880000114440918},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9449999928474426},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9520000219345093},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6899999976158142},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cytoskeletal-alterations","display_name":"cytoskeletal alterations","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neurofilament-aggregation","display_name":"neurofilament aggregation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.679298996925354},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6701688766479492},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.643462061882019},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5899066925048828},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.41616231203079224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36567121744155884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3310849070549011},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3167724609375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17681801319122314},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13437947630882263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13054290413856506},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08485844731330872}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/exnr.2000.7461","doi":"https://doi.org/10.1006/exnr.2000.7461","is_oa":true,"landing_page_url":"https://doi.org/10.1006/exnr.2000.7461","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:10964487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10964487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/exnr.2000.7461","doi":"https://doi.org/10.1006/exnr.2000.7461","is_oa":true,"landing_page_url":"https://doi.org/10.1006/exnr.2000.7461","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3919787194","display_name":null,"funder_award_id":"NS-08803","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4300107000","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG010124","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4361383882","display_name":"Molecular substrates of aging and neuron death","funder_award_id":"P01AG009215","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W138616876","https://openalex.org/W179188620","https://openalex.org/W948219868","https://openalex.org/W1517477926","https://openalex.org/W1522782595","https://openalex.org/W1527671059","https://openalex.org/W1536213364","https://openalex.org/W1540816663","https://openalex.org/W1566676785","https://openalex.org/W1568752613","https://openalex.org/W1572679174","https://openalex.org/W1601155059","https://openalex.org/W1796430339","https://openalex.org/W1879457624","https://openalex.org/W1921484215","https://openalex.org/W1960315548","https://openalex.org/W1962021636","https://openalex.org/W1963903234","https://openalex.org/W1973028673","https://openalex.org/W1985411011","https://openalex.org/W1986234504","https://openalex.org/W1986327756","https://openalex.org/W1995684956","https://openalex.org/W1998047781","https://openalex.org/W2000352412","https://openalex.org/W2002506451","https://openalex.org/W2004568898","https://openalex.org/W2008712625","https://openalex.org/W2013473672","https://openalex.org/W2015122191","https://openalex.org/W2016870828","https://openalex.org/W2018465654","https://openalex.org/W2018888883","https://openalex.org/W2021338058","https://openalex.org/W2025922492","https://openalex.org/W2027105684","https://openalex.org/W2028535633","https://openalex.org/W2033365056","https://openalex.org/W2034361518","https://openalex.org/W2035232504","https://openalex.org/W2036316405","https://openalex.org/W2037024974","https://openalex.org/W2038910860","https://openalex.org/W2039075247","https://openalex.org/W2042494739","https://openalex.org/W2054848243","https://openalex.org/W2057234710","https://openalex.org/W2058859054","https://openalex.org/W2061497413","https://openalex.org/W2062250460","https://openalex.org/W2064148637","https://openalex.org/W2066155243","https://openalex.org/W2067629356","https://openalex.org/W2071434138","https://openalex.org/W2073023359","https://openalex.org/W2074595931","https://openalex.org/W2081169924","https://openalex.org/W2082842430","https://openalex.org/W2083589438","https://openalex.org/W2083952664","https://openalex.org/W2085069351","https://openalex.org/W2085803660","https://openalex.org/W2086545066","https://openalex.org/W2090258462","https://openalex.org/W2122865490","https://openalex.org/W2123056519","https://openalex.org/W2126800086","https://openalex.org/W2133400638","https://openalex.org/W2136781825","https://openalex.org/W2138302361","https://openalex.org/W2146889361","https://openalex.org/W2149755594","https://openalex.org/W2158799442","https://openalex.org/W2168302341","https://openalex.org/W2400008990","https://openalex.org/W4234620764"],"related_works":["https://openalex.org/W2027105684","https://openalex.org/W2008249432","https://openalex.org/W3126850606","https://openalex.org/W1970110059","https://openalex.org/W4385798196","https://openalex.org/W1960315548","https://openalex.org/W2321538057","https://openalex.org/W2059869018","https://openalex.org/W1646952712","https://openalex.org/W3036009934"],"abstract_inverted_index":{"Several":[0],"neurodegenerative":[1,86,221],"disorders":[2,87],"are":[3],"characterized":[4],"by":[5,168],"filamentous":[6,56],"inclusions":[7,16,59,239],"in":[8,18,30,65,70,135,179,185,196,225],"neurons":[9,205],"that":[10,61,234],"selectively":[11],"degenerate.":[12],"The":[13,34,217],"role":[14],"these":[15,50,76],"play":[17],"neuron":[19,97,180],"degeneration":[20,69],"is":[21],"unclear,":[22],"but":[23,153],"this":[24,154],"issue":[25],"can":[26],"be":[27],"investigated":[28],"experimentally":[29],"relevant":[31],"animal":[32],"models.":[33],"NFH/LacZ":[35,227],"transgenic":[36],"(TG)":[37],"mice":[38,78,112,174,228,232],"overexpress":[39],"the":[40,66,82,94,124,146,172,186,197,201,226,235,242],"high-molecular-weight":[41],"neurofilament":[42],"(NF)":[43],"subunit":[44],"(NFH)":[45],"fused":[46],"to":[47,105,115,150,165,230],"beta-galactosidase,":[48],"and":[49,109,131,143,160,182,190,213,244],"hybrid":[51],"proteins":[52],"aggregate":[53],"into":[54],"NF-rich,":[55],"neuronal":[57],"cytoplasmic":[58],"(NCIs)":[60],"have":[62],"been":[63],"implicated":[64],"progressive,":[67],"age-dependent":[68],"subsets":[71],"of":[72,81,85,137,215,223,237,247],"affected":[73],"neurons.":[74,249],"Thus,":[75],"TG":[77,108,125,173],"recapitulate":[79],"some":[80],"key":[83],"pathology":[84],"with":[88],"intraneuronal":[89,238],"inclusions.":[90],"To":[91],"determine":[92],"if":[93],"NCIs":[95],"compromise":[96],"survival":[98],"following":[99],"traumatic":[100],"brain":[101],"injury":[102,147],"(TBI),":[103],"3-":[104],"6-month":[106],"old":[107],"wild-type":[110],"(WT)":[111],"were":[113],"subjected":[114],"TBI":[116,224],"or":[117],"sham":[118],"injury.":[119],"At":[120],"2":[121],"weeks":[122,159,170],"post-TBI,":[123],"group":[126],"showed":[127,175],"increased":[128,183],"TUNEL":[129],"staining":[130],"activated":[132],"caspase-3":[133],"immunoreactivity":[134],"cells":[136],"cerebral":[138],"cortex,":[139],"adjacent":[140],"white":[141],"matter,":[142],"hippocampus":[144],"underlying":[145],"site,":[148],"relative":[149],"control":[151,166],"mice,":[152,167],"labeling":[155],"decreased":[156,209],"at":[157],"4":[158],"was":[161],"minimal":[162],"thereafter.":[163],"Compared":[164],"8":[169],"postinjury,":[171],"a":[176],"marked":[177],"decrease":[178],"density":[181],"gliosis":[184],"hippocampal":[187],"dentate":[188],"gyrus":[189],"CA3":[191,204],"region":[192],"as":[193,195],"well":[194],"lateral":[198],"thalamus,":[199],"while":[200],"few":[202],"remaining":[203],"exhibited":[206],"cytoskeletal":[207],"alterations,":[208],"synaptic":[210],"protein":[211],"immunoreactivity,":[212],"dissolution":[214],"NCIs.":[216],"more":[218],"profound":[219],"long-term":[220,245],"sequelae":[222],"compared":[229],"WT":[231],"suggest":[233],"presence":[236],"may":[240],"impair":[241],"recovery":[243],"viability":[246],"injured":[248]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
