{"id":"https://openalex.org/W2094546720","doi":"https://doi.org/10.1093/carcin/22.2.315","title":"-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol","display_name":"-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2094546720","doi":"https://doi.org/10.1093/carcin/22.2.315","mag":"2094546720","pmid":"https://pubmed.ncbi.nlm.nih.gov/11181454"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/22.2.315","doi":"https://doi.org/10.1093/carcin/22.2.315","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/22.2.315","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C. A. Blum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Blum","raw_affiliation_strings":["Linus Pauling Institute and Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512, USA","Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","Linus Pauling Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linus Pauling Institute and Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512, USA","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Linus Pauling Institute and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011183162","display_name":"Meirong Xu","orcid":"https://orcid.org/0000-0001-6573-1179","observed_orcids":["https://orcid.org/0000-0001-6573-1179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Xu","raw_affiliation_strings":["Linus Pauling Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linus Pauling Institute and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111652014","display_name":"Gayle A. Orner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. A. Orner","raw_affiliation_strings":["Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","Linus Pauling Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Linus Pauling Institute and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113490535","display_name":"Arthur T. Fong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. T. Fong","raw_affiliation_strings":["Linus Pauling Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linus Pauling Institute and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111575816","display_name":"G.S. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. S. Bailey","raw_affiliation_strings":["Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032442574","display_name":"Gary D. Stoner","orcid":"https://orcid.org/0000-0002-7888-5609","observed_orcids":["https://orcid.org/0000-0002-7888-5609"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. D. Stoner","raw_affiliation_strings":["School of Public Health, Ohio State University, Columbus, OH 43210 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Ohio State University, Columbus, OH 43210 and","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076930994","display_name":"D. T. Horio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146218","display_name":"St. Francis Medical Center","ror":"https://ror.org/04sah3q11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146218"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. T. Horio","raw_affiliation_strings":["Department of Pathology, St Francis Medical Center, Honolulu, HI 96817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St Francis Medical Center, Honolulu, HI 96817, USA","institution_ids":["https://openalex.org/I4210146218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. H. Dashwood","raw_affiliation_strings":["Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","Linus Pauling Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environment and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-6512","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Linus Pauling Institute and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":2.3921,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.89030168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"2","first_page":"315","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.11159999668598175,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctnnb1-mutation","display_name":"CTNNB1 mutation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/1-2-dimethylhydrazine","display_name":"1,2-dimethylhydrazine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/2-amino-3-methylimidazo-4-5-f-quinoline","display_name":"2-amino-3-methylimidazo[4,5-f]quinoline","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chlorophyllin","display_name":"chlorophyllin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/indole-3-carbinol","display_name":"indole-3-carbinol","score":1.0},{"id":"https://openalex.org/keywords/dietary-phytochemicals","display_name":"dietary phytochemicals","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.765999972820282},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9710000157356262},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-multiplicity","display_name":"tumor multiplicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2780679280","wikidata":"https://www.wikidata.org/wiki/Q379123","display_name":"Chlorophyllin","level":3,"score":0.9274497032165527},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7558994293212891},{"id":"https://openalex.org/C2779932572","wikidata":"https://www.wikidata.org/wiki/Q161484","display_name":"1,2-Dimethylhydrazine","level":5,"score":0.5761244297027588},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5101883411407471},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.4996354579925537},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4647483229637146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4567315876483917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38222363591194153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3302341103553772},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.27409857511520386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16770035028457642},{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.13858169317245483},{"id":"https://openalex.org/C2776373379","wikidata":"https://www.wikidata.org/wiki/Q43177","display_name":"Chlorophyll","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002735","descriptor_name":"Chlorophyllides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007041","descriptor_name":"Hypoxanthine Phosphoribosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007041","descriptor_name":"Hypoxanthine Phosphoribosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019813","descriptor_name":"1,2-Dimethylhydrazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/22.2.315","doi":"https://doi.org/10.1093/carcin/22.2.315","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/22.2.315","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:11181454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11181454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1497661912","display_name":null,"funder_award_id":"ES-00-210","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G311403707","display_name":null,"funder_award_id":"CA-34732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4288126918","display_name":"Reducing Susceptibility to Environmental Stress Throughout the Life Span","funder_award_id":"P30ES000210","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5206365075","display_name":null,"funder_award_id":"CA80716","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5346176085","display_name":"MECHANISMS OF INHIBITION OF CHEMICAL CARCINOGENESIS","funder_award_id":"R01CA034732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G546173785","display_name":null,"funder_award_id":"CA-65525","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000893889","display_name":"Integrated Regional Training Program in Environmental Health Sciences (IRTP)","funder_award_id":"T32ES007060","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1547840953","https://openalex.org/W1554815317","https://openalex.org/W1963646022","https://openalex.org/W1967132242","https://openalex.org/W1967137553","https://openalex.org/W1967775878","https://openalex.org/W1970347740","https://openalex.org/W1983775809","https://openalex.org/W1986467863","https://openalex.org/W1989215255","https://openalex.org/W2002404925","https://openalex.org/W2013743651","https://openalex.org/W2014995450","https://openalex.org/W2017435089","https://openalex.org/W2026262319","https://openalex.org/W2034388580","https://openalex.org/W2043509153","https://openalex.org/W2046382187","https://openalex.org/W2047956822","https://openalex.org/W2053086049","https://openalex.org/W2058219019","https://openalex.org/W2081985759","https://openalex.org/W2084284247","https://openalex.org/W2090406571","https://openalex.org/W2104321396","https://openalex.org/W2122591546","https://openalex.org/W2125418297","https://openalex.org/W2127495334","https://openalex.org/W2134861913","https://openalex.org/W2138178697","https://openalex.org/W2142522741","https://openalex.org/W2148883613","https://openalex.org/W2166137435","https://openalex.org/W2314458206","https://openalex.org/W4200531859","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W4245098113","https://openalex.org/W2023957905","https://openalex.org/W2025026974","https://openalex.org/W2141535051","https://openalex.org/W2011284050","https://openalex.org/W2126588059","https://openalex.org/W2112877227","https://openalex.org/W2104321396","https://openalex.org/W2017435089","https://openalex.org/W2050124427"],"abstract_inverted_index":{"Carcinogens":[0],"2-amino-3-methylimidazo[4,5-f]quinoline":[1],"(IQ)":[2],"and":[3,71,88,108,110,155,186,189,191,226],"1,2-dimethylhydrazine":[4],"(DMH)":[5],"induce":[6],"colon":[7,28,54,83,120,165,214],"tumors":[8,84,125,178,199,215],"in":[9,15,26,52,63,81,97,104,118,133,146,158,164,212],"the":[10,18,35,56,64,76,94,124,139,172,207,228,232],"rat":[11,65,82,213],"that":[12,24,141,206,227],"contain":[13],"mutations":[14,33,59,80,96,132,140,211],"beta-catenin,":[16,42],"but":[17,43],"pattern":[19,77,208],"of":[20,41,58,78,93,123,138,182,209,235],"mutation":[21],"differs":[22],"from":[23,126,149],"found":[25],"human":[27,53,119],"cancers.":[29,121],"In":[30],"both":[31],"species,":[32],"affect":[34],"glycogen":[36],"synthase":[37],"kinase-3beta":[38],"consensus":[39],"region":[40],"whereas":[44],"they":[45],"directly":[46],"substitute":[47],"critical":[48,112,143],"Ser/Thr":[49,113,144],"phosphorylation":[50],"sites":[51],"cancers,":[55],"majority":[57],"cluster":[60],"around":[61],"Ser33":[62],"tumors.":[66],"Two":[67],"dietary":[68,222],"phytochemicals,":[69],"chlorophyllin":[70],"indole-3-carbinol,":[72],"given":[73,99,128,153,174],"post-initiation,":[74,225],"shifted":[75],"beta-catenin":[79,95,147,210],"induced":[85],"by":[86,219],"IQ":[87],"DMH.":[89],"Specifically,":[90],"17/39":[91],"(44%)":[92],"groups":[98,127],"carcinogen":[100,129],"plus":[101],"modulator":[102],"were":[103,148,194],"codons":[105],"37,":[106],"41":[107],"45,":[109],"substituted":[111,142],"residues":[114,145],"directly,":[115],"as":[116],"seen":[117],"None":[122],"alone":[130],"had":[131,179],"these":[134],"codons.":[135],"Interestingly,":[136],"many":[137],"a":[150,160],"single":[151],"group":[152,173],"DMH":[154,175],"0.001%":[156],"chlorophyllin,":[157],"which":[159],"statistically":[161],"significant":[162],"increase":[163],"tumor":[166],"multiplicity":[167],"was":[168],"observed":[169],"compared":[170,197],"with":[171,198],"only.":[176],"These":[177],"marked":[180],"over-expression":[181],"cyclin":[183],"D1,":[184],"c-myc":[185],"c-jun":[187],"mRNA":[188],"c-Myc":[190],"c-Jun":[192],"proteins":[193],"strongly":[195],"elevated":[196],"containing":[200],"wild-type":[201],"beta-catenin.":[202],"The":[203],"results":[204],"indicate":[205],"can":[216],"be":[217],"influenced":[218],"exposure":[220],"to":[221],"phytochemicals":[223],"administered":[224],"mechanism":[229],"might":[230],"involve":[231],"altered":[233],"expression":[234],"beta-catenin/Tcf/Lef":[236],"target":[237],"genes.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
