{"id":"https://openalex.org/W2094540101","doi":"https://doi.org/10.1016/s0022-2836(02)00625-3","title":"The Crystal Structure of Human \u03b11-Tryptase Reveals a Blocked Substrate-binding Region","display_name":"The Crystal Structure of Human \u03b11-Tryptase Reveals a Blocked Substrate-binding Region","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2094540101","doi":"https://doi.org/10.1016/s0022-2836(02)00625-3","mag":"2094540101","pmid":"https://pubmed.ncbi.nlm.nih.gov/12162961"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2836(02)00625-3","doi":"https://doi.org/10.1016/s0022-2836(02)00625-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(02)00625-3","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071736681","display_name":"Ulf Marquardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulf Marquardt","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried bei, M\u00fcnchen, Germany","Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried bei, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086468644","display_name":"Frank Zettl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Zettl","raw_affiliation_strings":["Abteilung f\u00fcr Klinische Chemie und Klinische Biochemie, Klinikumsstandort Innenstadt der Ludwig- Maximilians-Universit\u00e4t, Nu\u00dfbaumstra\u00dfe 20, D-80336 M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Klinische Chemie und Klinische Biochemie, Klinikumsstandort Innenstadt der Ludwig- Maximilians-Universit\u00e4t, Nu\u00dfbaumstra\u00dfe 20, D-80336 M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101832860","display_name":"Robert Huber","orcid":"https://orcid.org/0000-0002-0133-5334","observed_orcids":["https://orcid.org/0000-0002-0133-5334"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Huber","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried bei M\u00fcnchen, Germany","Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried bei M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109009178","display_name":"Wolfram Bode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfram Bode","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried bei M\u00fcnchen, Germany","Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried bei M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Huber, Robert / Structure Research, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054315140","display_name":"Christian P. Sommerhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian P. Sommerhoff","raw_affiliation_strings":["Abteilung f\u00fcr Klinische Chemie und Klinische Biochemie, Klinikumsstandort Innenstadt der Ludwig- Maximilians-Universit\u00e4t, Nu\u00dfbaumstra\u00dfe 20, D-80336 M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Klinische Chemie und Klinische Biochemie, Klinikumsstandort Innenstadt der Ludwig- Maximilians-Universit\u00e4t, Nu\u00dfbaumstra\u00dfe 20, D-80336 M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109009178"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":3.1291,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.92942214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"321","issue":"3","first_page":"491","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.296099990606308,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-crystal-structure","display_name":"protein crystal structure","score":0.6800000071525574},{"id":"https://openalex.org/keywords/substrate-binding-subsites","display_name":"substrate binding subsites","score":0.6650000214576721},{"id":"https://openalex.org/keywords/induced-fit","display_name":"induced fit","score":0.6039999723434448},{"id":"https://openalex.org/keywords/heparin-binding","display_name":"heparin binding","score":0.7940000295639038},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.8301262259483337},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.6131284236907959},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.6094977855682373},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5882337093353271},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.5523010492324829},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5363176465034485},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4558597207069397},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.43852171301841736},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.43185722827911377},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.4196430742740631},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40782228112220764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33079856634140015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2958158254623413},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.2376994788646698},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2258663773536682},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07084470987319946},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0022-2836(02)00625-3","doi":"https://doi.org/10.1016/s0022-2836(02)00625-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(02)00625-3","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:12162961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12162961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:41684","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/41684","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biology, v.321, 491-502 (2002)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1582017","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0010-6E7C-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1495261601","https://openalex.org/W1495415372","https://openalex.org/W1546896179","https://openalex.org/W1630458667","https://openalex.org/W1886491539","https://openalex.org/W1967258230","https://openalex.org/W1978176375","https://openalex.org/W1995017064","https://openalex.org/W1995609060","https://openalex.org/W1998331667","https://openalex.org/W2001913929","https://openalex.org/W2003262365","https://openalex.org/W2005340510","https://openalex.org/W2008708467","https://openalex.org/W2009754464","https://openalex.org/W2014694459","https://openalex.org/W2018837868","https://openalex.org/W2018964872","https://openalex.org/W2022284401","https://openalex.org/W2025509474","https://openalex.org/W2028231353","https://openalex.org/W2029708509","https://openalex.org/W2035813185","https://openalex.org/W2039908865","https://openalex.org/W2043576282","https://openalex.org/W2047173579","https://openalex.org/W2049371451","https://openalex.org/W2052511024","https://openalex.org/W2059140321","https://openalex.org/W2061584062","https://openalex.org/W2078701521","https://openalex.org/W2080528351","https://openalex.org/W2085005313","https://openalex.org/W2088521868","https://openalex.org/W2091969321","https://openalex.org/W2107108810","https://openalex.org/W2112218935","https://openalex.org/W2113440293","https://openalex.org/W2115315317","https://openalex.org/W2116275717","https://openalex.org/W2137665821","https://openalex.org/W2144908001","https://openalex.org/W2162992359","https://openalex.org/W2169218929","https://openalex.org/W2238510836"],"related_works":["https://openalex.org/W7140268861","https://openalex.org/W1978176375","https://openalex.org/W7095071702","https://openalex.org/W2099118109","https://openalex.org/W2078701521","https://openalex.org/W2115315317","https://openalex.org/W1886491539","https://openalex.org/W2127025854","https://openalex.org/W2163064583","https://openalex.org/W2059140321"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}