{"id":"https://openalex.org/W2094530557","doi":"https://doi.org/10.1016/0006-2952(81)90412-3","title":"Further studies on the in vivo effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the liver microsomal drug oxidation system in rats","display_name":"Further studies on the in vivo effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the liver microsomal drug oxidation system in rats","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W2094530557","doi":"https://doi.org/10.1016/0006-2952(81)90412-3","mag":"2094530557","pmid":"https://pubmed.ncbi.nlm.nih.gov/6119083"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(81)90412-3","doi":"https://doi.org/10.1016/0006-2952(81)90412-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(81)90412-3","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091821543","display_name":"Minoru Katoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134850","display_name":"Nihon Nohyaku (Japan)","ror":"https://ror.org/02s7nat60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210134850"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Katoh","raw_affiliation_strings":["Biological Research Center, Nihon Nohyaku Co. Ltd., Kawachinagano, Osaka 586, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Research Center, Nihon Nohyaku Co. Ltd., Kawachinagano, Osaka 586, Japan","institution_ids":["https://openalex.org/I4210134850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112177400","display_name":"Mitsukazu Kitada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsukazu Kitada","raw_affiliation_strings":["Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058876682","display_name":"Tetsuo Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuo Satoh","raw_affiliation_strings":["Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058991203","display_name":"Haruo Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruo Kitagawa","raw_affiliation_strings":["Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006286421","display_name":"Tatsuyoshi Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134850","display_name":"Nihon Nohyaku (Japan)","ror":"https://ror.org/02s7nat60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210134850"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuyoshi Sugimoto","raw_affiliation_strings":["Biological Research Center, Nihon Nohyaku Co. Ltd., Kawachinagano, Osaka 586, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Research Center, Nihon Nohyaku Co. Ltd., Kawachinagano, Osaka 586, Japan","institution_ids":["https://openalex.org/I4210134850"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110109060","display_name":"Tsutomu Kasai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134850","display_name":"Nihon Nohyaku (Japan)","ror":"https://ror.org/02s7nat60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210134850"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Kasai","raw_affiliation_strings":["Biological Research Center, Nihon Nohyaku Co. Ltd., Kawachinagano, Osaka 586, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Research Center, Nihon Nohyaku Co. Ltd., Kawachinagano, Osaka 586, Japan","institution_ids":["https://openalex.org/I4210134850"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058876682"],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.0903,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74329502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"20","first_page":"2759","last_page":"2765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cytochrome-b5","display_name":"cytochrome b5","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nadph-cytochrome-c-reductase","display_name":"NADPH-cytochrome c reductase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nadh-cytochrome-b5-reductase","display_name":"NADH-cytochrome b5 reductase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nadph-dependent-lipid-peroxidation","display_name":"NADPH-dependent lipid peroxidation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase","display_name":"stearoyl-CoA desaturase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/benzphetamine-n-demethylase","display_name":"benzphetamine N-demethylase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/p-nitroanisole-o-demethylase","display_name":"p-nitroanisole O-demethylase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aniline-hydroxylase","display_name":"aniline hydroxylase","score":0.996999979019165},{"id":"https://openalex.org/keywords/microsomal-electron-transport","display_name":"microsomal electron transport","score":0.7860000133514404},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2779384962","wikidata":"https://www.wikidata.org/wiki/Q5201346","display_name":"Cytochrome b5","level":4,"score":0.8409274220466614},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7594394087791443},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6853500604629517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6423993706703186},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5887512564659119},{"id":"https://openalex.org/C2777606763","wikidata":"https://www.wikidata.org/wiki/Q3322838","display_name":"Benzphetamine","level":4,"score":0.48164382576942444},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.4583441913127899},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4407743811607361},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4228544235229492},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.41395366191864014},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3975068926811218},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3681030869483948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3493833541870117},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27727991342544556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1775197982788086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13328668475151062},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.11428314447402954},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003579","descriptor_name":"Cytochrome Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008314","descriptor_name":"Malonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015786","descriptor_name":"Cytochromes b5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042966","descriptor_name":"Cytochrome-B(5) Reductase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(81)90412-3","doi":"https://doi.org/10.1016/0006-2952(81)90412-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(81)90412-3","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:6119083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6119083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W617062806","https://openalex.org/W1488511002","https://openalex.org/W1564990229","https://openalex.org/W1775749144","https://openalex.org/W1806194750","https://openalex.org/W1903873355","https://openalex.org/W1951469402","https://openalex.org/W1970587768","https://openalex.org/W1995240416","https://openalex.org/W1999922186","https://openalex.org/W2002846063","https://openalex.org/W2014616684","https://openalex.org/W2035929428","https://openalex.org/W2039786918","https://openalex.org/W2042172153","https://openalex.org/W2046273546","https://openalex.org/W2052736223","https://openalex.org/W2056700148","https://openalex.org/W2066260934","https://openalex.org/W2070534218","https://openalex.org/W2073614913","https://openalex.org/W2092076086","https://openalex.org/W2092354710","https://openalex.org/W2094466373","https://openalex.org/W2095294199","https://openalex.org/W2162305712","https://openalex.org/W2293096567","https://openalex.org/W2332118465"],"related_works":["https://openalex.org/W2092076086","https://openalex.org/W2312331059","https://openalex.org/W2125545578","https://openalex.org/W2420220210","https://openalex.org/W2143078268","https://openalex.org/W2331435706","https://openalex.org/W6991530479","https://openalex.org/W2002630124","https://openalex.org/W1974172069","https://openalex.org/W617062806"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}