{"id":"https://openalex.org/W2094438335","doi":"https://doi.org/10.1371/journal.pone.0021291","title":"Control of Centrin Stability by Aurora A","display_name":"Control of Centrin Stability by Aurora A","publication_year":2011,"publication_date":"2011-06-23","ids":{"openalex":"https://openalex.org/W2094438335","doi":"https://doi.org/10.1371/journal.pone.0021291","mag":"2094438335","pmid":"https://pubmed.ncbi.nlm.nih.gov/21731694","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121746"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0021291","doi":"https://doi.org/10.1371/journal.pone.0021291","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021291","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021291&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021291&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016644186","display_name":"Kara B. Lukasiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara B. Lukasiewicz","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083012777","display_name":"Tammy M. Greenwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy M. Greenwood","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068080696","display_name":"Vivian C. Negron","orcid":"https://orcid.org/0000-0003-2990-935X","observed_orcids":["https://orcid.org/0000-0003-2990-935X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivian C. Negron","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075477344","display_name":"Amy K. Bruzek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy K. Bruzek","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111611863","display_name":"Jeffrey L. Salisbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey L. Salisbury","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029305787","display_name":"Wilma L. Lingle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilma L. Lingle","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029305787","https://openalex.org/A5111611863"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2859,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.76190781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"6","first_page":"e21291","last_page":"e21291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.8090000152587891},{"id":"https://openalex.org/keywords/centrin","display_name":"centrin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/centrosome-amplification","display_name":"centrosome amplification","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.6549999713897705},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/anaphase-promoting-complex","display_name":"anaphase-promoting complex","score":0.7919999957084656},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.9248244762420654},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7109427452087402},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6528440117835999},{"id":"https://openalex.org/C20552341","wikidata":"https://www.wikidata.org/wiki/Q4822632","display_name":"Aurora inhibitor","level":4,"score":0.641779363155365},{"id":"https://openalex.org/C2779425043","wikidata":"https://www.wikidata.org/wiki/Q14905704","display_name":"Aurora A kinase","level":3,"score":0.5947544574737549},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5607687830924988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5506623387336731},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.418472021818161},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3780737817287445},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.33749818801879883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18171128630638123},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17917442321777344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05648508667945862},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064127","descriptor_name":"Aurora Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0021291","doi":"https://doi.org/10.1371/journal.pone.0021291","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021291","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021291&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3121746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21731694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21731694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.291.2896","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.291.2896","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1e/04/PLoS_One_2011_Jun_23_6(6)_e21291.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1b0d2007b87440e2992621ebed4187ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b0d2007b87440e2992621ebed4187ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 6, p e21291 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/135819","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Control_of_Centrin_Stability_by_Aurora_A/135819","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0021291","doi":"https://doi.org/10.1371/journal.pone.0021291","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021291","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021291&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G424082930","display_name":null,"funder_award_id":"CA116201","funder_id":"https://openalex.org/F4320306260","funder_display_name":"Breast Cancer Research Foundation"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7308422090","display_name":"Centrosome Amplification in Human Breast Cancer","funder_award_id":"R01CA072836","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000108363","display_name":null,"funder_award_id":"CA116201","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000912503","display_name":"Mayo Clinic Breast Cancer SPORE","funder_award_id":"P50CA116201","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2094438335.pdf","grobid_xml":"https://content.openalex.org/works/W2094438335.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1483395792","https://openalex.org/W1657157395","https://openalex.org/W1905076019","https://openalex.org/W1918385449","https://openalex.org/W1931117085","https://openalex.org/W1963981052","https://openalex.org/W1966622127","https://openalex.org/W1967149801","https://openalex.org/W1971796809","https://openalex.org/W1973897761","https://openalex.org/W1974778184","https://openalex.org/W1981427365","https://openalex.org/W1986157458","https://openalex.org/W1990317973","https://openalex.org/W1991033145","https://openalex.org/W1995947461","https://openalex.org/W2009941909","https://openalex.org/W2011575793","https://openalex.org/W2015141765","https://openalex.org/W2024729872","https://openalex.org/W2031752489","https://openalex.org/W2040154374","https://openalex.org/W2048734578","https://openalex.org/W2064337685","https://openalex.org/W2064949637","https://openalex.org/W2068121956","https://openalex.org/W2070787022","https://openalex.org/W2071221524","https://openalex.org/W2074635261","https://openalex.org/W2075000991","https://openalex.org/W2078010704","https://openalex.org/W2089596886","https://openalex.org/W2091312754","https://openalex.org/W2092608069","https://openalex.org/W2094790756","https://openalex.org/W2101453691","https://openalex.org/W2108541596","https://openalex.org/W2109903344","https://openalex.org/W2114873132","https://openalex.org/W2127442198","https://openalex.org/W2138515325","https://openalex.org/W2142565191","https://openalex.org/W2148299252","https://openalex.org/W2148933207","https://openalex.org/W2153903849","https://openalex.org/W2155923159","https://openalex.org/W2158160769","https://openalex.org/W2168234700","https://openalex.org/W2170710435"],"related_works":["https://openalex.org/W2003979653","https://openalex.org/W2325054656","https://openalex.org/W7100451478","https://openalex.org/W1272918884","https://openalex.org/W2170396837","https://openalex.org/W2142565191","https://openalex.org/W2100521311","https://openalex.org/W2355885148","https://openalex.org/W2015500590","https://openalex.org/W7096446885"],"abstract_inverted_index":{"Aurora":[0,22,33,68,87,110,155],"A":[1,23,34,69,88,111],"is":[2,81,150],"an":[3],"oncogenic":[4],"serine/threonine":[5],"kinase":[6,108],"which":[7],"can":[8],"cause":[9],"cell":[10],"transformation":[11],"and":[12,24,39,74,119,157],"centrosome":[13,75,79,164],"amplification":[14,80,165],"when":[15],"over-expressed.":[16],"Human":[17],"breast":[18],"tumors":[19],"show":[20,31],"excess":[21,72,159],"phospho-centrin":[25,73],"in":[26,61,71,84,89,113,116,152,166],"amplified":[27],"centrosomes.":[28],"Here,":[29],"we":[30],"that":[32,129,145,158],"mediates":[35],"the":[36,44,90,98,146],"phosphorylation":[37,100,132],"of":[38,64,67,92,106,121,148],"localizes":[40],"with":[41,46],"centrin":[42,95,122,127,131,149,161],"at":[43,102],"centrosome,":[45],"both":[47],"proteins":[48],"reaching":[49],"maximum":[50],"abundance":[51],"from":[52],"prophase":[53],"through":[54],"metaphase,":[55],"followed":[56],"by":[57,154],"their":[58],"precipitous":[59],"loss":[60],"late":[62],"stages":[63],"mitosis.":[65],"Over-expression":[66],"results":[70,112,143],"amplification.":[76],"In":[77],"contrast,":[78],"not":[82],"seen":[83],"cells":[85],"over-expressing":[86],"presence":[91],"a":[93,107,114,125],"recombinant":[94,126],"mutant":[96],"lacking":[97],"serine":[99],"site":[101],"residue":[103],"170.":[104],"Expression":[105],"dead":[109],"decrease":[115],"mitotic":[117],"index":[118],"abrogation":[120],"phosphorylation.":[123],"Finally,":[124],"mutation":[128],"mimics":[130],"increases":[133],"centrin's":[134],"stability":[135,147],"against":[136],"APC/C-mediated":[137],"proteasomal":[138],"degradation.":[139],"Taken":[140],"together,":[141],"these":[142],"suggest":[144],"regulated":[151],"part":[153],"A,":[156],"phosphorylated":[160],"may":[162],"promote":[163],"cancer.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}