{"id":"https://openalex.org/W2094436296","doi":"https://doi.org/10.1002/jlcr.2580271211","title":"An iterative synthesis of radiolabelled polyethylene glycol oligomers","display_name":"An iterative synthesis of radiolabelled polyethylene glycol oligomers","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2094436296","doi":"https://doi.org/10.1002/jlcr.2580271211","mag":"2094436296"},"language":"en","primary_location":{"id":"doi:10.1002/jlcr.2580271211","doi":"https://doi.org/10.1002/jlcr.2580271211","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.2580271211","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038023856","display_name":"Joseph F. Dellaria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph F. Dellaria","raw_affiliation_strings":["Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012444317","display_name":"Jon F. Denissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon F. Denissen","raw_affiliation_strings":["Drug Metabolism Department, D-463, Biotransformation Section, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism Department, D-463, Biotransformation Section, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040114369","display_name":"Francis A. J. Kerdesky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis A. J. Kerdesky","raw_affiliation_strings":["Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068677359","display_name":"Robert G. Maki","orcid":"https://orcid.org/0000-0002-9853-2528","observed_orcids":["https://orcid.org/0000-0002-9853-2528"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Maki","raw_affiliation_strings":["Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004171681","display_name":"Dani\u00ebl J. Hoffman","orcid":"https://orcid.org/0000-0002-9904-0568","observed_orcids":["https://orcid.org/0000-0002-9904-0568"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Hoffman","raw_affiliation_strings":["Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111837885","display_name":"Hugh N. Nellans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh N. Nellans","raw_affiliation_strings":["Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Laboratories, Pharmaceutical Products Division, D-47K, D-463, Biotransformation Section, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038023856"],"corresponding_institution_ids":["https://openalex.org/I4210088555"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.4199,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68111572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"12","first_page":"1437","last_page":"1450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.33079999685287476,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyethylene-glycol-oligomers","display_name":"polyethylene glycol oligomers","score":0.968999981880188},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.652999997138977},{"id":"https://openalex.org/keywords/tritium-labeling","display_name":"tritium labeling","score":0.7820000052452087},{"id":"https://openalex.org/keywords/iterative-synthesis","display_name":"iterative synthesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ozonolysis","display_name":"ozonolysis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/sodium-borohydride-reduction","display_name":"sodium borohydride reduction","score":0.7850000262260437},{"id":"https://openalex.org/keywords/radiochemical-purity","display_name":"radiochemical purity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/specific-activity","display_name":"specific activity","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.877324104309082},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.8728020787239075},{"id":"https://openalex.org/C2775934670","wikidata":"https://www.wikidata.org/wiki/Q420630","display_name":"Triethylene glycol","level":2,"score":0.8604673147201538},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.7380985021591187},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.728243887424469},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.5960890054702759},{"id":"https://openalex.org/C2779384521","wikidata":"https://www.wikidata.org/wiki/Q409889","display_name":"Polypropylene glycol","level":3,"score":0.5676590204238892},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.5302075147628784},{"id":"https://openalex.org/C2778718427","wikidata":"https://www.wikidata.org/wiki/Q539566","display_name":"Tosyl","level":2,"score":0.4567171335220337},{"id":"https://openalex.org/C51886252","wikidata":"https://www.wikidata.org/wiki/Q4118667","display_name":"Olefin fiber","level":3,"score":0.435764342546463},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3380630612373352},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3337239623069763},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06835430860519409},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jlcr.2580271211","doi":"https://doi.org/10.1002/jlcr.2580271211","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.2580271211","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W104408508","https://openalex.org/W1992282851","https://openalex.org/W2065672888","https://openalex.org/W2079487863","https://openalex.org/W2084571618","https://openalex.org/W2773032584","https://openalex.org/W4319308457"],"related_works":["https://openalex.org/W2099675522","https://openalex.org/W2034263606","https://openalex.org/W2406437758","https://openalex.org/W1965581337","https://openalex.org/W2088893357","https://openalex.org/W2087872465","https://openalex.org/W2016706241","https://openalex.org/W2132723462","https://openalex.org/W1971998266","https://openalex.org/W2083659437"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"synthetic":[2],"method":[3,78],"has":[4],"been":[5],"developed":[6],"for":[7],"the":[8,22,41,52,64,74],"iterative":[9,75],"preparation":[10],"of":[11,25,40,83],"unlabelled":[12],"and":[13],"3H\u2010polyethylene":[14],"glycol":[15,28,34,57,66],"(PEG)":[16],"oligomers.":[17],"The":[18,77],"strategy":[19],"involved":[20],"alkylating":[21],"sodium":[23],"anion":[24],"mono\u2010tritylated":[26,55],"ethylene":[27,56],"oligomers":[29,82],"(Ph3C[OCH2CH2]nOH,":[30],"n=1\u221228)":[31],"with":[32,47],"O\u2010tosyl\u2010O\u2010allyl\u2010triethylene":[33],"or":[35,49,70],"O\u2010tosyl\u2010O\u2010allyl\u2010pentaethylene":[36],"glycol.":[37],"Subsequent":[38],"ozonolysis":[39],"terminal":[42],"olefin":[43],"followed":[44],"by":[45],"reduction":[46],"NaBH4":[48],"NaB[3H]4":[50],"provided":[51],"next":[53],"higher":[54],"oligomer":[58,67],"which":[59],"could":[60],"be":[61],"deprotected":[62],"to":[63],"final":[65],"(H[OCH2CH2]nOH,":[68],"n=4\u221234)":[69],"carried":[71],"on":[72],"in":[73,89],"process.":[76],"provides":[79],"discrete":[80],"PEG":[81],"high":[84],"specific":[85],"activity":[86],"(20.6\u201348.6":[87],"mCi/mmoL)":[88],"96\u201398%":[90],"radiochemical":[91],"purity.":[92]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}