{"id":"https://openalex.org/W2094423969","doi":"https://doi.org/10.1021/bi800576c","title":"Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms","display_name":"Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms","publication_year":2008,"publication_date":"2008-06-13","ids":{"openalex":"https://openalex.org/W2094423969","doi":"https://doi.org/10.1021/bi800576c","mag":"2094423969","pmid":"https://pubmed.ncbi.nlm.nih.gov/18549248"},"language":"en","primary_location":{"id":"doi:10.1021/bi800576c","doi":"https://doi.org/10.1021/bi800576c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi800576c","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091399120","display_name":"Theresa Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Martinez","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119","Department of Analytical and Formulation Sciences, Process and Product Development, Amgen, Inc., Seattle, Washington 98119, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Department of Analytical and Formulation Sciences, Process and Product Development, Amgen, Inc., Seattle, Washington 98119, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019925558","display_name":"Amy X. Guo","orcid":"https://orcid.org/0000-0003-0180-3844","observed_orcids":["https://orcid.org/0000-0003-0180-3844"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Guo","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Martin J. Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. Allen","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088536475","display_name":"Mei Han","orcid":"https://orcid.org/0000-0001-7105-6835","observed_orcids":["https://orcid.org/0000-0001-7105-6835"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Han","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113622015","display_name":"Danielle L. Pace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle Pace","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103427371","display_name":"J. Bryan Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Jones","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015424589","display_name":"Ron Gillespie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Gillespie","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058986967","display_name":"Randal R. Ketchem","orcid":"https://orcid.org/0000-0002-7821-2682","observed_orcids":["https://orcid.org/0000-0002-7821-2682"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randal R. Ketchem","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101975891","display_name":"Yuling Zhang","orcid":"https://orcid.org/0000-0002-5761-1633","observed_orcids":["https://orcid.org/0000-0002-5761-1633"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuling Zhang","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079589390","display_name":"Alain Balland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alain Balland","raw_affiliation_strings":["Process and Product Development, Amgen, Inc., Seattle, Washington 98119"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process and Product Development, Amgen, Inc., Seattle, Washington 98119","institution_ids":["https://openalex.org/I1320553840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079589390"],"corresponding_institution_ids":["https://openalex.org/I1320553840"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.276,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.8790287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"47","issue":"28","first_page":"7496","last_page":"7508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igg2","display_name":"IgG2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/disulfide-connectivity","display_name":"disulfide connectivity","score":0.75},{"id":"https://openalex.org/keywords/hinge-region","display_name":"hinge region","score":0.9629999995231628},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.7900000214576721},{"id":"https://openalex.org/keywords/fc-domain","display_name":"Fc domain","score":0.5329999923706055},{"id":"https://openalex.org/keywords/heavy-chain","display_name":"heavy chain","score":0.38199999928474426},{"id":"https://openalex.org/keywords/light-chain","display_name":"light chain","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.800000011920929},{"id":"https://openalex.org/keywords/antibody-subclasses","display_name":"antibody subclasses","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.7353665232658386},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7191567420959473},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.7172188758850098},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5996909737586975},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.5630171298980713},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.5486626029014587},{"id":"https://openalex.org/C2776194381","wikidata":"https://www.wikidata.org/wiki/Q3965271","display_name":"Subclass","level":3,"score":0.5140877366065979},{"id":"https://openalex.org/C44000306","wikidata":"https://www.wikidata.org/wiki/Q244330","display_name":"Hinge","level":2,"score":0.4984772205352783},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.48877689242362976},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.46868422627449036},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.44812482595443726},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.43855154514312744},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4305001497268677},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.41129952669143677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3942681550979614},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.389277845621109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18951699137687683},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1099933385848999},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10967236757278442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09984919428825378},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09164237976074219},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi800576c","doi":"https://doi.org/10.1021/bi800576c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi800576c","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:18549248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18549248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.582.4862","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.582.4862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ketchem.net/papers/Biochemistry_v47_p7496_2008.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W200202785","https://openalex.org/W1484092314","https://openalex.org/W1493053489","https://openalex.org/W1497874406","https://openalex.org/W1541707585","https://openalex.org/W1965066688","https://openalex.org/W1986864699","https://openalex.org/W1991613630","https://openalex.org/W1998952334","https://openalex.org/W2004290717","https://openalex.org/W2009671611","https://openalex.org/W2011038859","https://openalex.org/W2013053064","https://openalex.org/W2017344199","https://openalex.org/W2023505225","https://openalex.org/W2030932286","https://openalex.org/W2042712910","https://openalex.org/W2050656150","https://openalex.org/W2054032387","https://openalex.org/W2059435741","https://openalex.org/W2068766896","https://openalex.org/W2076667355","https://openalex.org/W2087638630","https://openalex.org/W2096387523","https://openalex.org/W2098326902","https://openalex.org/W2108791168","https://openalex.org/W2153138530","https://openalex.org/W2165398738","https://openalex.org/W4236072577","https://openalex.org/W4293253343"],"related_works":["https://openalex.org/W2042712910","https://openalex.org/W1967133265","https://openalex.org/W2161808348","https://openalex.org/W1967905613","https://openalex.org/W2004290717","https://openalex.org/W2332649031","https://openalex.org/W2025273391","https://openalex.org/W2005208786","https://openalex.org/W200202785","https://openalex.org/W105040907"],"abstract_inverted_index":{"In":[0],"this":[1,153],"communication":[2],"we":[3],"present":[4],"the":[5,20,57,62,68,86,94,116,133,146],"detailed":[6],"disulfide":[7,63,102],"structure":[8,128],"of":[9,16,49,60,100,110,145],"IgG2":[10,35,69,95,127],"molecules.":[11],"The":[12],"consensus":[13],"structural":[14,46,137],"model":[15,42,138],"human":[17],"IgGs":[18],"represents":[19],"hinge":[21,89,117],"region":[22,118],"positioned":[23],"as":[24],"a":[25,111],"flexible":[26],"linker":[27],"connecting":[28],"structurally":[29],"isolated":[30],"Fc":[31],"and":[32,43,65,72,139],"Fab":[33],"domains.":[34],"molecules":[36],"are":[37,78],"organized":[38],"differently":[39],"from":[40,132],"that":[41,67,126],"exhibit":[44],"multiple":[45],"isoforms":[47],"composed":[48],"(heavy":[50],"chain-light":[51],"chain-hinge)":[52],"covalent":[53],"complexes.":[54,122],"We":[55],"describe":[56],"precise":[58],"connection":[59],"all":[61],"bridges":[64,103],"show":[66,125],"C":[70,74],"H1":[71],"C-terminal":[73],"L":[75],"cysteine":[76,90,113],"residues":[77,91],"either":[79],"linked":[80],"to":[81,85,93,106,142,152],"each":[82,107],"other":[83],"or":[84],"two":[87],"upper":[88],"specific":[92],"subclass.":[96,154],"A":[97],"defined":[98],"arrangement":[99],"these":[101,120],"is":[104,129],"unique":[105,147],"isoform.":[108],"Mutation":[109],"single":[112],"residue":[114],"in":[115],"eliminates":[119],"natural":[121],"These":[123],"results":[124],"significantly":[130],"different":[131],"conventionally":[134],"accepted":[135],"immunoglobulin":[136],"may":[140],"help":[141],"explain":[143],"some":[144],"biological":[148],"activity":[149],"attributed":[150],"only":[151]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
