{"id":"https://openalex.org/W2094374136","doi":"https://doi.org/10.1249/01.mss.0000162690.39830.27","title":"Increased IGF mRNA in Human Skeletal Muscle after Creatine Supplementation","display_name":"Increased IGF mRNA in Human Skeletal Muscle after Creatine Supplementation","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2094374136","doi":"https://doi.org/10.1249/01.mss.0000162690.39830.27","mag":"2094374136","pmid":"https://pubmed.ncbi.nlm.nih.gov/15870625"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000162690.39830.27","doi":"https://doi.org/10.1249/01.mss.0000162690.39830.27","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000162690.39830.27","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/008a76c5-1c27-4d14-8cd7-4796bc46e935","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053866214","display_name":"Louise Deldicque","orcid":"https://orcid.org/0000-0003-3393-5278","observed_orcids":["https://orcid.org/0000-0003-3393-5278"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"LOUISE DELDICQUE","raw_affiliation_strings":["Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103521224","display_name":"Magali Louis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"MAGALI LOUIS","raw_affiliation_strings":["Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018604403","display_name":"Daniel Theisen","orcid":"https://orcid.org/0000-0002-9699-3013","observed_orcids":["https://orcid.org/0000-0002-9699-3013"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"DANIEL THEISEN","raw_affiliation_strings":["Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055050105","display_name":"Henri Nielens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"HENRI NIELENS","raw_affiliation_strings":["Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111871839","display_name":"MISCHA L DEHOUX","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"MISCHA??L DEHOUX","raw_affiliation_strings":["Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM","Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM; and","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091888132","display_name":"Jean\u2010Paul Thissen","orcid":"https://orcid.org/0000-0001-9165-0364","observed_orcids":["https://orcid.org/0000-0001-9165-0364"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"JEAN-PAUL THISSEN","raw_affiliation_strings":["Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM","Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Unit of Diabetology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, BELGIUM; and","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077156226","display_name":"Michael John Rennie","orcid":"https://orcid.org/0000-0001-5590-139X","observed_orcids":["https://orcid.org/0000-0001-5590-139X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"MICHAEL J. RENNIE","raw_affiliation_strings":["School of Biomedical Sciences, University of Nottingham Graduate Entry Medical School, Derby, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, University of Nottingham Graduate Entry Medical School, Derby, UNITED KINGDOM","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077988213","display_name":"Marc Francaux","orcid":"https://orcid.org/0000-0001-8182-1588","observed_orcids":["https://orcid.org/0000-0001-8182-1588"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"MARC FRANCAUX","raw_affiliation_strings":["Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, BELGIUM","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4234,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.92067414,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"5","first_page":"731","last_page":"736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-supplementation","display_name":"creatine supplementation","score":1.0},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7919999957084656},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6539999842643738},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.7120000123977661},{"id":"https://openalex.org/keywords/muscle-anabolism","display_name":"muscle anabolism","score":0.7789999842643738},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.7200000286102295},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.746999979019165},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6479021906852722},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.6331063508987427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5670813322067261},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5399326086044312},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.48820215463638306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4007076919078827},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3122563362121582},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0991874635219574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08783307671546936}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038762","descriptor_name":"Ribosomal Protein S6 Kinases, 70-kDa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1249/01.mss.0000162690.39830.27","doi":"https://doi.org/10.1249/01.mss.0000162690.39830.27","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000162690.39830.27","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},{"id":"pmid:15870625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15870625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine and science in sports and exercise","raw_type":"Clinical Trial"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/279694","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/279694","pdf_url":"https://lirias.kuleuven.be/retrieve/008a76c5-1c27-4d14-8cd7-4796bc46e935","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicine and Science in Sports and Exercise, vol. 37 (5), (731-736)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:23946","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/23946","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicine and Science in Sports and Exercise, Vol. 37, no. 5, p. 731-736 (2005)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/279694","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/279694","pdf_url":"https://lirias.kuleuven.be/retrieve/008a76c5-1c27-4d14-8cd7-4796bc46e935","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicine and Science in Sports and Exercise, vol. 37 (5), (731-736)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2094374136.pdf","grobid_xml":"https://content.openalex.org/works/W2094374136.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W18401714","https://openalex.org/W38278793","https://openalex.org/W1964531354","https://openalex.org/W1972527462","https://openalex.org/W1987105275","https://openalex.org/W2006797658","https://openalex.org/W2015674575","https://openalex.org/W2019460978","https://openalex.org/W2025796648","https://openalex.org/W2044279551","https://openalex.org/W2048762660","https://openalex.org/W2051855988","https://openalex.org/W2054460914","https://openalex.org/W2062871288","https://openalex.org/W2070000694","https://openalex.org/W2073704146","https://openalex.org/W2077120302","https://openalex.org/W2090407808","https://openalex.org/W2093571366","https://openalex.org/W2108064524","https://openalex.org/W2113689204","https://openalex.org/W2117012616","https://openalex.org/W2129254209","https://openalex.org/W2135914921","https://openalex.org/W2144679216","https://openalex.org/W2146343352","https://openalex.org/W2147838095","https://openalex.org/W2157054897","https://openalex.org/W2165604666","https://openalex.org/W2339005651"],"related_works":["https://openalex.org/W2109129960","https://openalex.org/W7056168377","https://openalex.org/W2085225177","https://openalex.org/W2129254209","https://openalex.org/W2137457916","https://openalex.org/W1988322909","https://openalex.org/W6999515379","https://openalex.org/W2135914921","https://openalex.org/W2117347524","https://openalex.org/W2140907180"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"hypothesized":[2],"that":[3],"creatine":[4,59,89,134,191,204,221,239,257],"supplementation":[5,258],"would":[6],"facilitate":[7],"muscle":[8,67,137],"anabolism":[9],"by":[10,157,174,190,203,262],"increasing":[11],"the":[12,18,27,36,72,100,105,230,238],"expression":[13],"of":[14,20,29,39,41,51,58,196,208,233],"growth":[15],"factors":[16],"and":[17,33,35,46,78,80,122,147,167,173,198,220,267],"phosphorylation":[19,37,194,207,231],"anabolic":[21,42],"signaling":[22,43,263],"molecules;":[23],"we":[24],"therefore":[25],"tested":[26],"responses":[28],"mRNA":[30,140],"for":[31,92,141],"IGF-I":[32,142,162,179],"IGF-II":[34,148,168],"state":[38,232],"components":[40],"pathways":[44],"p70(s6k)":[45,197],"4E-BP1":[47,199,234],"to":[48,215],"a":[49,63,110],"bout":[50],"high-intensity":[52],"resistance":[53],"exercise":[54],"after":[55,256],"5":[56,93],"d":[57,94],"supplementation.":[60,192],"METHODS:":[61],"In":[62],"double-blind":[64],"cross-over":[65],"design,":[66],"biopsies":[68],"were":[69,107,200],"taken":[70,88],"from":[71],"m.":[73],"vastus":[74],"lateralis":[75],"at":[76,205,223,243],"rest":[77],"3":[79,102,158,224],"24":[81,175,244],"h":[82,103,159,176,225,245],"postexercise":[83,160,177,226],"in":[84,161,178,237,250],"subjects":[85,106],"who":[86],"had":[87],"or":[90],"placebo":[91,219,241],"(21":[95],"g":[96,115,125],"x":[97,116,120,126,130],"d(-1)).":[98],"For":[99],"first":[101],"postexercise,":[104],"fed":[108],"with":[109],"drink":[111],"containing":[112],"maltodextrin":[113],"(0.3":[114],"kg(-1)":[117,127],"body":[118,128,252],"weight":[119,129],"h(-1))":[121],"protein":[123],"(0.08":[124],"h(-1)).":[131],"RESULTS:":[132],"After":[133],"supplementation,":[135],"resting":[136],"expressed":[138],"more":[139],"(+30%,":[143],"P":[144,150,164,170,181,212],"<":[145,165,171,182,213],"0.05)":[146,166,172,214],"(+40%,":[149],"=":[151],"0.054).":[152],"Exercise":[153],"caused":[154],"an":[155],"increase":[156,249],"(+24%,":[163],"(+48%,":[169],"(+29%,":[180],"0.05),":[183],"but":[184],"this":[185],"effect":[186],"was":[187,235],"not":[188,201],"potentiated":[189],"The":[193,248],"states":[195],"affected":[202],"rest;":[206],"both":[209],"increased":[210],"(150-400%,":[211],"similar":[216],"levels":[217],"under":[218],"conditions":[222],"plus":[227],"feeding.":[228],"However,":[229],"higher":[236],"versus":[240],"condition":[242],"postexercise.":[246],"CONCLUSION:":[247],"lean":[251],"mass":[253],"often":[254],"reported":[255],"could":[259],"be":[260],"mediated":[261],"pathway(s)":[264],"involving":[265],"IGF":[266],"4E-BP1.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}