{"id":"https://openalex.org/W2094258156","doi":"https://doi.org/10.1160/th05-04-0248","title":"Interaction of N\u03b5(carboxymethyl)lysine- and methylglyoxalmodified albumin with endothelial cells and macrophages","display_name":"Interaction of N\u03b5(carboxymethyl)lysine- and methylglyoxalmodified albumin with endothelial cells and macrophages","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2094258156","doi":"https://doi.org/10.1160/th05-04-0248","mag":"2094258156","pmid":"https://pubmed.ncbi.nlm.nih.gov/16493495"},"language":"en","primary_location":{"id":"doi:10.1160/th05-04-0248","doi":"https://doi.org/10.1160/th05-04-0248","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th05-04-0248","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015099690","display_name":"Mariska Lieuw-a-Fa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mariska Lieuw-a-Fa","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Maastricht, Debeyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Maastricht, Debeyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072505788","display_name":"Marten A. Engelse","orcid":"https://orcid.org/0000-0003-1341-8521","observed_orcids":["https://orcid.org/0000-0003-1341-8521"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marten Engelse","raw_affiliation_strings":["Department of Physiology, Vrije Universiteit Medical Centre, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Vrije Universiteit Medical Centre, Amsterdam","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112245045","display_name":"Victor W.M. van Hinsbergh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Victor van Hinsbergh","raw_affiliation_strings":["Department of Physiology, Vrije Universiteit Medical Centre, Amsterdam","Gaubius Laboratory TNO-PG, Leiden, The Netherlands","Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Vrije Universiteit Medical Centre, Amsterdam","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Gaubius Laboratory TNO-PG, Leiden, The Netherlands","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031265369","display_name":"Casper G. Schalkwijk","orcid":"https://orcid.org/0000-0003-0190-2690","observed_orcids":["https://orcid.org/0000-0003-0190-2690"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Casper Schalkwijk","raw_affiliation_strings":["Department of Clinical Chemistry and Vrije Universiteit Medical Centre, Amsterdam","Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Vrije Universiteit Medical Centre, Amsterdam","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031265369"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":null,"apc_paid":null,"fwci":1.7344,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.81638847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"02","first_page":"320","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.8679999709129333},{"id":"https://openalex.org/keywords/nepsilon-carboxymethyl-lysine","display_name":"carboxymethyllysine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.9919999837875366},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.8859999775886536},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.8930000066757202},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/scavenger-receptors","display_name":"scavenger receptors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.7174004316329956},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.7006306052207947},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5897398591041565},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.5780930519104004},{"id":"https://openalex.org/C2778592357","wikidata":"https://www.wikidata.org/wiki/Q903881","display_name":"Methylglyoxal","level":3,"score":0.5659936666488647},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.529385507106781},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.48321616649627686},{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.4719371497631073},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4506925046443939},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.44412586092948914},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4328688383102417},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3895517587661743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38023337721824646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35525399446487427},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3374873101711273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30388107895851135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28688356280326843},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.286854088306427},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.09170001745223999},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011765","descriptor_name":"Pyruvaldehyde","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1160/th05-04-0248","doi":"https://doi.org/10.1160/th05-04-0248","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th05-04-0248","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:16493495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16493495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:oai-pmh.tno.nl:58459","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:f826f37a-02a7-4051-8bee-7cc1be4d91aa","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thrombosis and Haemostasis, 95(2), pp. 320-328.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321708","display_name":"Diabetes Fonds","ror":"https://ror.org/04ch2g225"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1503258737","https://openalex.org/W1757241200","https://openalex.org/W1970936597","https://openalex.org/W1978094951","https://openalex.org/W1978611180","https://openalex.org/W1990773395","https://openalex.org/W1992221756","https://openalex.org/W1992484293","https://openalex.org/W1993143422","https://openalex.org/W1999499773","https://openalex.org/W2000782226","https://openalex.org/W2010014413","https://openalex.org/W2013633841","https://openalex.org/W2015483600","https://openalex.org/W2017984282","https://openalex.org/W2018620079","https://openalex.org/W2021346724","https://openalex.org/W2035759625","https://openalex.org/W2035899511","https://openalex.org/W2047347825","https://openalex.org/W2047561204","https://openalex.org/W2052963492","https://openalex.org/W2058597871","https://openalex.org/W2060895623","https://openalex.org/W2065012620","https://openalex.org/W2071675524","https://openalex.org/W2073714833","https://openalex.org/W2082468315","https://openalex.org/W2089315626","https://openalex.org/W2090679314","https://openalex.org/W2106697731","https://openalex.org/W2108349235","https://openalex.org/W2115293825","https://openalex.org/W2124098523","https://openalex.org/W2126160998","https://openalex.org/W2131615503","https://openalex.org/W2138928713","https://openalex.org/W2143321563","https://openalex.org/W2144319892","https://openalex.org/W2144725045","https://openalex.org/W2157490824","https://openalex.org/W2157603347","https://openalex.org/W2335364913"],"related_works":["https://openalex.org/W7132626636","https://openalex.org/W2381195243","https://openalex.org/W2372902393","https://openalex.org/W2106697731","https://openalex.org/W2002607484","https://openalex.org/W2034904299","https://openalex.org/W6948730175","https://openalex.org/W2052963492","https://openalex.org/W151770906","https://openalex.org/W7096296261"],"abstract_inverted_index":{"In":[0,105,162,186,204,224],"diabetes":[1],"mellitus":[2],"an":[3],"increased":[4],"risk":[5],"exists":[6],"for":[7,12],"vascular":[8,21,58],"complications.":[9],"A":[10],"role":[11],"advanced":[13],"glycation":[14],"endproducts":[15],"(AGEs)":[16],"in":[17,53,215,245],"the":[18,44,89,138,145,196,250],"acceleration":[19],"of":[20,40,88,92,98,132,140,153,170,183,202,230,240,243,252,254],"disease":[22],"has":[23],"been":[24,33],"suggested.":[25],"Nepsilon-(carboxymethyl)lysine":[26],"(CML)-":[27],"and":[28,48,67,83,95,113,119,155,190,198],"methylglyoxal":[29],"(MGO)-modified":[30],"proteins":[31],"have":[32],"identified":[34],"as":[35,135],"major":[36],"AGEs.":[37],"The":[38,86,238],"interaction":[39,253],"these":[41,158,231,258],"AGEs":[42,93,232,256],"with":[43,80,111,226,257],"human":[45,75,187],"endothelial":[46,76,117,133,165,192,222,236,246],"cells":[47,77,118,134,159,193,247],"macrophages":[49,174],"was":[50,100,160,175,219,233],"studied.":[51],"Changes":[52],"adhesion":[54,60,64,141,216],"molecule":[55,217],"expression,":[56],"i.e.":[57],"cell":[59],"molecule-1":[61,65],"(VCAM-1),":[62],"intercellular":[63],"(ICAM-1)":[66],"E-selectin":[68],"were":[69,109],"determined":[70,101],"by":[71,102,137,181],"cell-bound":[72],"Elisa":[73],"on":[74,157,221],"after":[78],"incubation":[79],"CML-modified":[81],"albumin":[82,115],"MGO-modified":[84,114],"albumin.":[85],"presence":[87],"full-length":[90],"receptor":[91],"(RAGE)":[94],"splice":[96,200,241],"variants":[97,201,242],"RAGE":[99,244],"specific":[103,151,168],"RT-PCR.":[104],"addition,":[106],"binding":[107,152,169,229],"studies":[108],"performed":[110],"CML-":[112,211],"to":[116,164,172,235],"P388D1":[120,173],"macrophages.":[121],"We":[122],"demonstrated":[123],"that":[124],"CML-albumin":[125,154],"or":[126,212],"MGO-albumin":[127,156,171],"did":[128],"not":[129],"induce":[130],"activation":[131],"measured":[136],"expression":[139,218],"molecules,":[142],"while,":[143],"under":[144,206],"same":[146],"conditions,":[147],"TNF-alpha":[148],"did.":[149],"No":[150],"found.":[161],"contrast":[163],"cells,":[166],"a":[167],"demonstrated,":[176],"which":[177],"could":[178],"be":[179],"competed":[180],"ligands":[182],"scavenger":[184],"receptors.":[185],"umbilical":[188],"vein":[189],"microvascular":[191],"we":[194],"found":[195,220,234],"N-truncated":[197],"C-truncated":[199],"RAGE.":[203],"conclusion,":[205],"our":[207],"experimental":[208],"conditions":[209],"no":[210,228],"MGO-albumin-induced":[213],"increase":[214],"cells.":[223,237,259],"agreement":[225],"this,":[227],"existence":[239],"might":[248],"explain":[249],"lack":[251],"extracellular":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}