{"id":"https://openalex.org/W2094246014","doi":"https://doi.org/10.1117/12.878029","title":"Automatic detection, segmentation and characterization of retinal horizontal neurons in large-scale 3D confocal imagery","display_name":"Automatic detection, segmentation and characterization of retinal horizontal neurons in large-scale 3D confocal imagery","publication_year":2011,"publication_date":"2011-03-03","ids":{"openalex":"https://openalex.org/W2094246014","doi":"https://doi.org/10.1117/12.878029","mag":"2094246014"},"language":"en","primary_location":{"id":"doi:10.1117/12.878029","doi":"https://doi.org/10.1117/12.878029","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.878029","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060643572","display_name":"Mahmut Karakaya","orcid":"https://orcid.org/0000-0001-5087-0918","observed_orcids":["https://orcid.org/0000-0001-5087-0918"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmut Karakaya","raw_affiliation_strings":["The Univ. of Tennessee (United States)","The University of Tennessee, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Tennessee (United States)","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"The University of Tennessee, United States","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058149524","display_name":"Ryan A. Kerekes","orcid":"https://orcid.org/0000-0001-7199-811X","observed_orcids":["https://orcid.org/0000-0001-7199-811X"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Kerekes","raw_affiliation_strings":["Oak Ridge National Lab. (United States)","Oak Ridge National Laboratories (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Lab. (United States)","institution_ids":["https://openalex.org/I1289243028"]},{"raw_affiliation_string":"Oak Ridge National Laboratories (United States)","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109876339","display_name":"Shaun S. Gleason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaun S. Gleason","raw_affiliation_strings":["Oak Ridge National Lab. (United States)","Oak Ridge National Laboratories (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Lab. (United States)","institution_ids":["https://openalex.org/I1289243028"]},{"raw_affiliation_string":"Oak Ridge National Laboratories (United States)","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070090297","display_name":"Rodrigo A. P. Martins","orcid":"https://orcid.org/0000-0002-8420-6991","observed_orcids":["https://orcid.org/0000-0002-8420-6991"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo A. P. Martins","raw_affiliation_strings":["Univ. Federal do Rio de Janeiro (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Federal do Rio de Janeiro (Brazil)","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023634801","display_name":"Michael A. Dyer","orcid":"https://orcid.org/0000-0003-4027-4850","observed_orcids":["https://orcid.org/0000-0003-4027-4850"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Dyer","raw_affiliation_strings":["St. Jude Children's Research Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Research Hospital (United States)","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.25316456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7962","issue":null,"first_page":"79622J","last_page":"79622J"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuron-classification","display_name":"neuron classification","score":0.6970000267028809},{"id":"https://openalex.org/keywords/snakes","display_name":"snakes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/morphological-operators","display_name":"morphological operators","score":0.8240000009536743},{"id":"https://openalex.org/keywords/skeletonization","display_name":"skeletonization","score":0.843999981880188},{"id":"https://openalex.org/keywords/network-analysis","display_name":"network analysis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/shape-features","display_name":"shape features","score":0.9670000076293945},{"id":"https://openalex.org/keywords/3d-confocal-microscopy","display_name":"3D confocal microscopy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"neuronal morphology","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C23951316","wikidata":"https://www.wikidata.org/wiki/Q1984140","display_name":"Skeletonization","level":2,"score":0.9196099042892456},{"id":"https://openalex.org/C2779617337","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Soma","level":2,"score":0.7470328211784363},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7191211581230164},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6780992746353149},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6245071291923523},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5824082493782043},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5502290725708008},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4981808662414551},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4828634560108185},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.453050822019577},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.4300905466079712},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.41591233015060425},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2883686423301697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14540201425552368},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1273392140865326},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.11084076762199402},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.878029","doi":"https://doi.org/10.1117/12.878029","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.878029","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142230529","https://openalex.org/W2009431558","https://openalex.org/W2058534929","https://openalex.org/W2134448814","https://openalex.org/W1969855607","https://openalex.org/W1998874218","https://openalex.org/W2068569682","https://openalex.org/W2083877563","https://openalex.org/W2333017092","https://openalex.org/W1657684222"],"abstract_inverted_index":{"Automatic":[0],"analysis":[1,138],"of":[2,10,36,44,58,66,89,129,144,155],"neuronal":[3,18],"structure":[4,88],"from":[5,69,152],"wide-field-of-view":[6],"3D":[7,49],"image":[8,51,103],"stacks":[9],"retinal":[11],"neurons":[12],"is":[13],"essential":[14],"for":[15,33,80,188],"statistically":[16],"characterizing":[17],"abnormalities":[19],"that":[20,171,180],"may":[21,29],"be":[22,30],"causally":[23],"related":[24],"to":[25,85,126,139,158,175],"neural":[26],"malfunctions":[27],"or":[28],"early":[31],"indicators":[32],"a":[34,53,74,117],"variety":[35],"neuropathies.":[37],"In":[38,92],"this":[39],"paper,":[40],"we":[41,95,120,169,172],"study":[42],"classification":[43,82],"neuron":[45,81,157],"fields":[46],"in":[47,101],"large-scale":[48],"confocal":[50],"stacks,":[52],"challenging":[54],"neurobiological":[55],"problem":[56],"because":[57],"the":[59,86,102,141,160],"low":[60],"spatial":[61],"resolution":[62],"imagery":[63],"and":[64,108,136,147,166,185],"presence":[65],"intertwined":[67],"dendrites":[68,128],"different":[70],"neurons.":[71,194],"We":[72,132],"present":[73],"fully":[75],"automated,":[76],"four-step":[77],"processing":[78],"approach":[79],"with":[83],"respect":[84],"morphological":[87,106,142],"their":[90],"dendrites.":[91],"our":[93],"approach,":[94],"first":[96],"localize":[97],"each":[98,113,130,156],"individual":[99],"soma":[100,114],"by":[104],"using":[105,112],"operators":[107],"active":[109],"contours.":[110],"By":[111],"position":[115],"as":[116],"seed":[118],"point,":[119],"automatically":[121,176],"determine":[122],"an":[123],"appropriate":[124],"threshold":[125],"segment":[127],"neuron.":[131,161],"then":[133],"use":[134],"skeletonization":[135],"network":[137,153],"generate":[140],"structures":[143],"segmented":[145],"dendrites,":[146],"shape-based":[148],"features":[149,179],"are":[150,173],"extracted":[151],"representations":[154],"characterize":[159],"Based":[162],"on":[163],"qualitative":[164],"results":[165],"quantitative":[167],"comparisons,":[168],"show":[170],"able":[174],"compute":[177],"relevant":[178],"clearly":[181],"distinguish":[182],"between":[183],"normal":[184],"abnormal":[186],"cases":[187],"postnatal":[189],"day":[190],"6":[191],"(P6)":[192],"horizontal":[193]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}