{"id":"https://openalex.org/W2094231237","doi":"https://doi.org/10.1016/s0278-6915(02)00211-9","title":"Evaluation of styrene oligomers eluted from polystyrene for estrogenicity in estrogen receptor binding assay, reporter gene assay, and uterotrophic assay","display_name":"Evaluation of styrene oligomers eluted from polystyrene for estrogenicity in estrogen receptor binding assay, reporter gene assay, and uterotrophic assay","publication_year":2002,"publication_date":"2002-12-02","ids":{"openalex":"https://openalex.org/W2094231237","doi":"https://doi.org/10.1016/s0278-6915(02)00211-9","mag":"2094231237","pmid":"https://pubmed.ncbi.nlm.nih.gov/12453737"},"language":"en","primary_location":{"id":"doi:10.1016/s0278-6915(02)00211-9","doi":"https://doi.org/10.1016/s0278-6915(02)00211-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0278-6915(02)00211-9","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112271370","display_name":"K. Ohno","orcid":"https://orcid.org/0009-0000-4847-748X","observed_orcids":["https://orcid.org/0009-0000-4847-748X"]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"K Ohno","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan. k-ono@mbl.nissinfoods.co.jp","Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan. k-ono@mbl.nissinfoods.co.jp","institution_ids":["https://openalex.org/I4405274152"]},{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061138237","display_name":"Yukimasa Azuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Azuma","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012674110","display_name":"Katsuhiro Date","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Date","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041464056","display_name":"Shigeru Nakano","orcid":"https://orcid.org/0000-0001-5345-8232","observed_orcids":["https://orcid.org/0000-0001-5345-8232"]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Nakano","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043013184","display_name":"Toru Kobayashi","orcid":"https://orcid.org/0009-0004-6986-4437","observed_orcids":["https://orcid.org/0009-0004-6986-4437"]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kobayashi","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051405232","display_name":"Yasuhiro Nagao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Nagao","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042703297","display_name":"Tomoya Yamada","orcid":"https://orcid.org/0000-0002-9798-1049","observed_orcids":["https://orcid.org/0000-0002-9798-1049"]},"institutions":[{"id":"https://openalex.org/I4405274152","display_name":"Nissin FOOD Products Co., Ltd. (Japan)","ror":"https://ror.org/015qjs208","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274152"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Yamada","raw_affiliation_strings":["Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan","institution_ids":["https://openalex.org/I4405274152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112271370"],"corresponding_institution_ids":["https://openalex.org/I4405274152"],"apc_list":{"value":4670,"currency":"USD","value_usd":4670},"apc_paid":null,"fwci":1.439,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76854209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"41","issue":"1","first_page":"131","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/styrene-dimers","display_name":"styrene dimers","score":0.878000020980835},{"id":"https://openalex.org/keywords/styrene-trimer","display_name":"styrene trimer","score":1.0},{"id":"https://openalex.org/keywords/styrene-oligomers","display_name":"styrene oligomers","score":0.9639999866485596},{"id":"https://openalex.org/keywords/estrogenic-activity","display_name":"estrogenic activity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/estrogen-receptor-binding","display_name":"estrogen receptor binding","score":0.8450000286102295},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.6620000004768372},{"id":"https://openalex.org/keywords/uterotrophic-assay","display_name":"uterotrophic assay","score":0.8600000143051147},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.6933188438415527},{"id":"https://openalex.org/C85196483","wikidata":"https://www.wikidata.org/wiki/Q6545857","display_name":"Ligand binding assay","level":3,"score":0.6819067597389221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6708098649978638},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.45941174030303955},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4408940076828003},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.42314791679382324},{"id":"https://openalex.org/C2777566558","wikidata":"https://www.wikidata.org/wiki/Q28917","display_name":"Styrene","level":4,"score":0.4152679443359375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3171868324279785},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2415851354598999},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21518740057945251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21093088388442993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2033272683620453},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1886063814163208},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1490601897239685},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.07759273052215576},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005506","descriptor_name":"Food Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018857","descriptor_name":"Food Packaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020058","descriptor_name":"Styrene","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020058","descriptor_name":"Styrene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0278-6915(02)00211-9","doi":"https://doi.org/10.1016/s0278-6915(02)00211-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0278-6915(02)00211-9","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},{"id":"pmid:12453737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12453737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1549850749","https://openalex.org/W1986310133","https://openalex.org/W1999426074","https://openalex.org/W2007331274","https://openalex.org/W2007796268","https://openalex.org/W2031634836","https://openalex.org/W2031839969","https://openalex.org/W2042124938","https://openalex.org/W2052287190","https://openalex.org/W2052505467","https://openalex.org/W2061947638","https://openalex.org/W2064398144","https://openalex.org/W2073587390","https://openalex.org/W2074727275","https://openalex.org/W2084026465","https://openalex.org/W2085698470","https://openalex.org/W2089175593","https://openalex.org/W2106162177","https://openalex.org/W2118057169","https://openalex.org/W2124411815","https://openalex.org/W2140087383","https://openalex.org/W2151063137","https://openalex.org/W2159217959","https://openalex.org/W2162603825","https://openalex.org/W2166537089","https://openalex.org/W2307575554","https://openalex.org/W2333379716","https://openalex.org/W2404741295","https://openalex.org/W2511883906","https://openalex.org/W2950422125","https://openalex.org/W3103065917","https://openalex.org/W4252121394","https://openalex.org/W6683223455"],"related_works":["https://openalex.org/W7100941009","https://openalex.org/W2074727275","https://openalex.org/W2511883906","https://openalex.org/W2052287190","https://openalex.org/W2007796268","https://openalex.org/W2079119201","https://openalex.org/W3103065917","https://openalex.org/W2103370499","https://openalex.org/W7098454684","https://openalex.org/W2031839969"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}