{"id":"https://openalex.org/W2094079006","doi":"https://doi.org/10.1021/jm950701k","title":"Synthesis and Antiviral Activity of 2\u2018-Deoxy-4\u2018-thio Purine Nucleosides","display_name":"Synthesis and Antiviral Activity of 2\u2018-Deoxy-4\u2018-thio Purine Nucleosides","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2094079006","doi":"https://doi.org/10.1021/jm950701k","mag":"2094079006","pmid":"https://pubmed.ncbi.nlm.nih.gov/8558524"},"language":"en","primary_location":{"id":"doi:10.1021/jm950701k","doi":"https://doi.org/10.1021/jm950701k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm950701k","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039713500","display_name":"Nanine A. Van Draanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanine A. Van Draanen","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111954194","display_name":"George A. Freeman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George A. Freeman","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112794583","display_name":"Steven A. Short","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven A. Short","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Harvey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Harvey","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112237859","display_name":"Robert W. Jansen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Jansen","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029965179","display_name":"George M. Szczech","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Szczech","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073798859","display_name":"George W. Koszalka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George W. Koszalka","raw_affiliation_strings":["Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Experimental Therapy, Organic Chemistry, Biochemistry, and Toxicology, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.9764,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.97411566,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"2","first_page":"538","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.28130000829696655,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.28130000829696655,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.23170000314712524,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purine-nucleosides","display_name":"purine nucleosides","score":0.8149999976158142},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9660000205039978},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.790340781211853},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.7149309515953064},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6444796919822693},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.64402836561203},{"id":"https://openalex.org/C2781253882","wikidata":"https://www.wikidata.org/wiki/Q770860","display_name":"Thio-","level":2,"score":0.618187665939331},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5974390506744385},{"id":"https://openalex.org/C2776159415","wikidata":"https://www.wikidata.org/wiki/Q6868","display_name":"Varicella zoster virus","level":3,"score":0.5300699472427368},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5240134000778198},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5070950984954834},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.48598799109458923},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.4777863919734955},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47415369749069214},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.42128676176071167},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4015640616416931},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23661324381828308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12246721982955933},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0931856632232666},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006564","descriptor_name":"Herpesviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm950701k","doi":"https://doi.org/10.1021/jm950701k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm950701k","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:8558524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8558524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W581386893","https://openalex.org/W1572997030","https://openalex.org/W1963717906","https://openalex.org/W1971054608","https://openalex.org/W1976530842","https://openalex.org/W1979244076","https://openalex.org/W2000806364","https://openalex.org/W2006225254","https://openalex.org/W2007268648","https://openalex.org/W2014401319","https://openalex.org/W2016295109","https://openalex.org/W2017395882","https://openalex.org/W2022414255","https://openalex.org/W2022747839","https://openalex.org/W2030984044","https://openalex.org/W2042732243","https://openalex.org/W2044599279","https://openalex.org/W2059489120","https://openalex.org/W2064276205","https://openalex.org/W2075659616","https://openalex.org/W2163782658","https://openalex.org/W2333876883","https://openalex.org/W2951063443","https://openalex.org/W2952626442","https://openalex.org/W2953143001","https://openalex.org/W4244330609"],"related_works":["https://openalex.org/W4236346500","https://openalex.org/W2003959971","https://openalex.org/W2952128406","https://openalex.org/W2030984044","https://openalex.org/W2949484676","https://openalex.org/W2031115448","https://openalex.org/W2085771844","https://openalex.org/W2087023118","https://openalex.org/W2029415141","https://openalex.org/W2953067435"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,11,16,67],"2'-deoxy-4'-thioribo":[3],"purine":[4,17,31],"nucleosides":[5],"was":[6,62,95,112],"prepared":[7],"by":[8],"trans-N-deoxyribosylase-catalyzed":[9],"reaction":[10],"2'-deoxy-4'-thiouridine":[12],"with":[13],"a":[14,65],"variety":[15],"bases.":[18],"This":[19],"synthetic":[20],"procedure":[21],"is":[22],"an":[23],"improvement":[24],"over":[25],"methods":[26],"previously":[27],"used":[28],"to":[29,82],"prepare":[30],"4'-thio":[32],"nucleosides.":[33],"The":[34,87],"compounds":[35,71],"were":[36,72],"tested":[37,115],"against":[38,75,102],"hepatitis":[39],"B":[40],"virus":[41,48,54,59],"(HBV),":[42],"human":[43,57],"cytomegalovirus":[44],"(HCMV),":[45],"herpes":[46],"simplex":[47],"(HSV-1":[49],"and":[50,56,77,79,99,104],"HSV-2),":[51],"varicella":[52],"zoster":[53],"(VZV),":[55],"immunodeficiency":[58],"(HIV-1).":[60],"Cytotoxicity":[61],"determined":[63],"in":[64,85,107,116],"number":[66],"cell":[68],"lines.":[69],"Several":[70],"extremely":[73],"potent":[74,98],"HBV":[76,105],"HCMV":[78,103],"had":[80],"moderate":[81],"severe":[83],"cytotoxicity":[84],"vitro.":[86],"lead":[88],"compound":[89],"from":[90],"the":[91,96],"series,":[92],"2-amino-6-(cyclopropylamino)purine":[93],"2'-deoxy-4'-thioriboside,":[94],"most":[97],"selective":[100],"agent":[101],"replication":[106],"vitro;":[108],"however,":[109],"this":[110],"analogue":[111],"nephrotoxic":[113],"when":[114],"vivo.":[117]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
