{"id":"https://openalex.org/W2094044280","doi":"https://doi.org/10.3892/ijo.13.4.827","title":"Chromatin, nuclear matrix and the cytoskeleton: role of cell structure in neoplastic transformation (review).","display_name":"Chromatin, nuclear matrix and the cytoskeleton: role of cell structure in neoplastic transformation (review).","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2094044280","doi":"https://doi.org/10.3892/ijo.13.4.827","mag":"2094044280","pmid":"https://pubmed.ncbi.nlm.nih.gov/9735414"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.13.4.827","doi":"https://doi.org/10.3892/ijo.13.4.827","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.13.4.827","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045335789","display_name":"Laurel T. Holth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L T Holth","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024588859","display_name":"Deborah N. Chadee","orcid":"https://orcid.org/0000-0002-5223-4701","observed_orcids":["https://orcid.org/0000-0002-5223-4701"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D N Chadee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039002471","display_name":"Virginia A. Spencer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"V A Spencer","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112180004","display_name":"Shanti K. Samuel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S K Samuel","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074518003","display_name":"Janice R. Safneck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J R Safneck","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048849645","display_name":"James Davie","orcid":"https://orcid.org/0000-0002-0420-6888","observed_orcids":["https://orcid.org/0000-0002-0420-6888"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J R Davie","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada","institution_ids":["https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I46247651"],"apc_list":null,"apc_paid":null,"fwci":1.627,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.83548595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":"4","first_page":"827","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.21369999647140503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.9089999794960022},{"id":"https://openalex.org/keywords/nuclear-matrix","display_name":"nuclear matrix","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":1.0},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cancer-genesis","display_name":"cancer genesis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.652999997138977},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9259999990463257},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6940000057220459},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9430000185966492},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/histone-phosphorylation","display_name":"histone phosphorylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C105686024","wikidata":"https://www.wikidata.org/wiki/Q906755","display_name":"Nuclear matrix","level":4,"score":0.9180121421813965},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7579174041748047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6839272379875183},{"id":"https://openalex.org/C56262557","wikidata":"https://www.wikidata.org/wiki/Q3931949","display_name":"Scaffold/matrix attachment region","level":5,"score":0.6748993396759033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.672630786895752},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5409061312675476},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5259271264076233},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.518247127532959},{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.5024359226226807},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.48970893025398254},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.48510754108428955},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4375465512275696},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.4335476756095886},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42432183027267456},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.4015972912311554},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36813926696777344},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.24215400218963623},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2162608504295349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16951340436935425},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1365116536617279}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015530","descriptor_name":"Nuclear Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015530","descriptor_name":"Nuclear Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.13.4.827","doi":"https://doi.org/10.3892/ijo.13.4.827","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.13.4.827","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:9735414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9735414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062800683","https://openalex.org/W1965335659","https://openalex.org/W1640261473","https://openalex.org/W271605806","https://openalex.org/W1964563458","https://openalex.org/W2489730805","https://openalex.org/W7098542362","https://openalex.org/W2025312356","https://openalex.org/W2065995858","https://openalex.org/W2011438179"],"abstract_inverted_index":{"Aberrant":[0],"nuclear":[1,40,68],"and":[2,24,42,67,71,99],"cellular":[3],"structures":[4],"are":[5,74],"hallmarks":[6],"of":[7,19,37,48,52,87],"malignant":[8],"transformation.":[9],"Thus":[10],"it":[11],"is":[12,25,55],"not":[13],"surprising":[14],"that":[15],"the":[16,20,35,38,46,77,83],"three-dimensional":[17,84],"structure":[18,44,106],"cell":[21,54],"both":[22],"affects":[23],"affected":[26],"by":[27,57],"changes":[28],"in":[29,45,80,82,102,108],"gene":[30],"expression.":[31],"Here":[32],"we":[33],"review":[34],"role":[36],"cytoskeleton,":[39],"matrix,":[41,61,65],"chromatin":[43,85,105],"genesis":[47],"cancer.":[49],"The":[50,89],"shape":[51],"a":[53,58,103],"governed":[56],"dynamic":[59],"tissue":[60],"which":[62],"includes":[63],"extracellular":[64],"cytoskeleton":[66],"matrix.":[69],"Mechanical":[70],"chemical":[72],"signals":[73],"transmitted":[75],"to":[76],"nucleus,":[78],"resulting":[79,101],"alterations":[81],"organization":[86],"genes.":[88],"signal":[90],"transduction":[91],"pathways":[92],"affect":[93],"histone":[94],"modifications,":[95],"such":[96],"as":[97],"acetylation":[98],"phosphorylation,":[100],"relaxed":[104],"observed":[107],"oncogene-transformed":[109],"cells.":[110]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
