{"id":"https://openalex.org/W2094035901","doi":"https://doi.org/10.1210/jcem-50-6-1049","title":"Plasma Glycoprotein Hormone \u03b1-Subunit in the Syndrome of Gonadal Dysgenesis: The Effect of Estrogen Replacement in Hypergonadotropic Hypogonadism*","display_name":"Plasma Glycoprotein Hormone \u03b1-Subunit in the Syndrome of Gonadal Dysgenesis: The Effect of Estrogen Replacement in Hypergonadotropic Hypogonadism*","publication_year":1980,"publication_date":"1980-06-01","ids":{"openalex":"https://openalex.org/W2094035901","doi":"https://doi.org/10.1210/jcem-50-6-1049","mag":"2094035901","pmid":"https://pubmed.ncbi.nlm.nih.gov/6246142"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-50-6-1049","doi":"https://doi.org/10.1210/jcem-50-6-1049","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-50-6-1049","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111726316","display_name":"Dennis M. Styne","orcid":"https://orcid.org/0000-0002-9978-5244","observed_orcids":["https://orcid.org/0000-0002-9978-5244"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DENNIS M. STYNE","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108401706","display_name":"Felix A. Conte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FELIX A. CONTE","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011827648","display_name":"Melvin M. Grumbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MELVIN M. GRUMBACH","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108398767","display_name":"Selna L. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SELNA L. KAPLAN","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.20688267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"6","first_page":"1049","last_page":"1052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.04270000010728836,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadal-dysgenesis","display_name":"gonadal dysgenesis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hypergonadotropic-hypogonadism","display_name":"hypergonadotropic hypogonadism","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glycoprotein-hormone-alpha-subunit","display_name":"glycoprotein hormone alpha-subunit","score":0.9139999747276306},{"id":"https://openalex.org/keywords/estrogen-replacement-therapy","display_name":"estrogen replacement therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/conjugated-estrogens","display_name":"conjugated estrogens","score":0.9369999766349792},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9750000238418579},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.996999979019165},{"id":"https://openalex.org/keywords/plasma-gonadotropins","display_name":"plasma gonadotropins","score":0.6769999861717224},{"id":"https://openalex.org/keywords/adolescent-girls","display_name":"adolescent girls","score":0.5260000228881836},{"id":"https://openalex.org/keywords/primary-hypothyroidism","display_name":"primary hypothyroidism","score":0.6399999856948853},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.4790000021457672},{"id":"https://openalex.org/keywords/gonadotropin-secretion-regulation","display_name":"gonadotropin secretion regulation","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8163032531738281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8095195889472961},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.7907533645629883},{"id":"https://openalex.org/C2780302854","wikidata":"https://www.wikidata.org/wiki/Q5958036","display_name":"Hypergonadotropic hypogonadism","level":3,"score":0.7358438968658447},{"id":"https://openalex.org/C2778324535","wikidata":"https://www.wikidata.org/wiki/Q1332427","display_name":"Gonadal dysgenesis","level":2,"score":0.7216137051582336},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.49968767166137695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4627627730369568},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4550701975822449},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.44086629152297974},{"id":"https://openalex.org/C2779812711","wikidata":"https://www.wikidata.org/wiki/Q5319415","display_name":"Dysgenesis","level":2,"score":0.4378052055835724},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.42298102378845215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34677308797836304},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07796177268028259},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004966","descriptor_name":"Estrogens, Conjugated (USP)","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006059","descriptor_name":"Gonadal Dysgenesis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006060","descriptor_name":"Gonadal Dysgenesis, Mixed","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006060","descriptor_name":"Gonadal Dysgenesis, Mixed","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014424","descriptor_name":"Turner Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014424","descriptor_name":"Turner Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-50-6-1049","doi":"https://doi.org/10.1210/jcem-50-6-1049","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-50-6-1049","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:6246142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6246142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085593681","https://openalex.org/W2591934954","https://openalex.org/W2062684015","https://openalex.org/W1983182382","https://openalex.org/W1514161951","https://openalex.org/W2067229604","https://openalex.org/W2399099516","https://openalex.org/W2059252082","https://openalex.org/W2395563943","https://openalex.org/W2043393598"],"abstract_inverted_index":{"Elevated":[0],"plasma":[1,149,180,229,262],"LH":[2,183,263,316],"and":[3,45,78,83,92,98,101,105,115,120,129,135,138,142,147,169,178,182,199,226,245,260,269,272,280],"FSH":[4,201,274],"levels":[5,74],"in":[6,17,154,167,185,194,203,217,235,242,287],"hypergonadotropic":[7],"hypogonadism":[8],"can":[9],"be":[10],"reduced":[11],"byestrogen":[12],"therapy,":[13],"but":[14,302],"the":[15,39,76,84,113,121,218,266,282,285,300,303,312],"change":[16],"readily":[18],"releasable":[19],"glycoprotein":[20,72],"hormone":[21,73],"\u03b1-subunit":[22,181,230,251,286,306],"with":[23,51,157,206,238,311,318],"therapy":[24,50,249,257],"is":[25,293,307],"undefined.":[26],"We":[27,221],"administered":[28],"100":[29],"\u03bcg":[30],"LRF":[31],"iv":[32],"to":[33,253,265,276],"seven":[34,64],"patients":[35,156,171,187,205,237,288],"(11\u201319":[36],"yr":[37],"old)with":[38],"syndrome":[40],"of":[41,49,57,284,305,314,320],"gonadal":[42,80,117,158,207,239],"dysgenesis":[43,81,118,159,208,240],"before":[44],"during":[46],"9":[47],"months":[48],"oral":[52],"conjugatedestrogens":[53],"at":[54],"a":[55,277],"dose":[56,247],"0.3":[58],"mg/day.":[59],"The":[60,175],"control":[61,85,122,195,219],"group":[62,86,123],"was":[63],"normal":[65,243,267],"girls,":[66],"aged":[67],"12\u201316":[68],"yr.":[69],"Mean":[70,108,145,197],"basal":[71,146,177,198,225,259,271],"for":[75,112],"untreated":[77,114,155,236],"treated":[79,116,170,186,204],"groups":[82,119],"were,":[87,124],"respectively:":[88,125],"\u03b1-subunit,":[89,126,150],"4.2,":[90],"1.3,":[91],"0.8":[93],"ng/ml;":[94,100,131,137],"LH,":[95,132,151],"9.3,":[96],"3.3,":[97],"1.4":[99],"FSH,":[102,139],"46.7,":[103],"17.8,":[104],"1.6":[106],"ng/ml.":[107,144],"peak":[109,148,179,200,227],"LRF-stimulated":[110,228,261,273],"values":[111,231],"18.9,":[127],"5.1,":[128],"3.7":[130],"43.4,":[133],"11.8,":[134],"6.4":[136],"78.0,":[140],"23.3,":[141],"3.6":[143],"andFSH":[152],"concentrations":[153,184,202,252,264,275],"were":[160,188,209],"higher":[161,211,234],"(P":[162,172,212],"<":[163,173,213],"0.005)":[164],"than":[165,192,215,241,317],"those":[166,193,216],"controls":[168],"0.05).":[174],"mean":[176],"not":[189],"significantly":[190,210,233],"different":[191],"patients.":[196],"0.05)":[214],"group.":[220],"conclude":[222],"that":[223,319],"1)":[224],"are":[232,299],"girls":[244],"low":[246],"estrogen":[248,256],"decreases":[250],"normal;":[254],"2)":[255],"lowers":[258,270],"range":[268],"lesser":[278],"degree;":[279],"3)":[281],"release":[283],"without":[289],"primary":[290],"thyroid":[291],"disease":[292],"stimulated":[294],"by":[295],"hypothalamic":[296],"LRF,":[297],"as":[298],"gonadotropins,":[301],"secretion":[304,313],"more":[308],"closely":[309],"associated":[310],"human":[315,321],"FSH.":[322]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}