{"id":"https://openalex.org/W2094015015","doi":"https://doi.org/10.1371/journal.pone.0074053","title":"Distal Effect of Amino Acid Substitutions in CYP2C9 Polymorphic Variants Causes Differences in Interatomic Interactions against (S)-Warfarin","display_name":"Distal Effect of Amino Acid Substitutions in CYP2C9 Polymorphic Variants Causes Differences in Interatomic Interactions against (S)-Warfarin","publication_year":2013,"publication_date":"2013-09-02","ids":{"openalex":"https://openalex.org/W2094015015","doi":"https://doi.org/10.1371/journal.pone.0074053","mag":"2094015015","pmid":"https://pubmed.ncbi.nlm.nih.gov/24023924","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759441"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0074053","doi":"https://doi.org/10.1371/journal.pone.0074053","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074053","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074053&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074053&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067172101","display_name":"Panida Lertkiatmongkol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Panida Lertkiatmongkol","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand ; Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand ; Department of Microbiology, University of Washington, Seattle, Washington, United States of America","Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand","Department of Microbiology, University of Washington, Seattle, Washington, United States of America","Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand ; Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand ; Department of Microbiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I25399158","https://openalex.org/I902798049"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand","institution_ids":["https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036611424","display_name":"Anunchai Assawamakin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Anunchai Assawamakin","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111926923","display_name":"George W. N. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George White","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066358077","display_name":"Gaurav Chopra","orcid":"https://orcid.org/0000-0003-0942-7898","observed_orcids":["https://orcid.org/0000-0003-0942-7898","https://orcid.org/0000-0001-5250-6255"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav Chopra","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle, Washington, United States of America","Diabetes Center, University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Diabetes Center, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015568373","display_name":"Pornpimol Rongnoparut","orcid":"https://orcid.org/0000-0002-5859-3940","observed_orcids":["https://orcid.org/0000-0002-5859-3940"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pornpimol Rongnoparut","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059358345","display_name":"Ram Samudrala","orcid":"https://orcid.org/0000-0001-9069-8497","observed_orcids":["https://orcid.org/0000-0001-9069-8497"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Samudrala","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046419753","display_name":"Sissades Tongsima","orcid":"https://orcid.org/0000-0002-1491-1839","observed_orcids":["https://orcid.org/0000-0002-1491-1839"]},"institutions":[{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Sissades Tongsima","raw_affiliation_strings":["Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand","institution_ids":["https://openalex.org/I902798049"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046419753"],"corresponding_institution_ids":["https://openalex.org/I902798049"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.0562,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7143007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"e74053","last_page":"e74053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.9620000123977661},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.7089999914169312},{"id":"https://openalex.org/keywords/single-amino-acid-substitution","display_name":"single amino acid substitution","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cyp2c9-2","display_name":"CYP2C9*2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cyp2c9-3","display_name":"CYP2C9*3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytochrome-p450-polymorphisms","display_name":"cytochrome P450 polymorphisms","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7519999742507935},{"id":"https://openalex.org/keywords/interatomic-interactions","display_name":"interatomic interactions","score":0.8140000104904175},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.6809999942779541},{"id":"https://openalex.org/keywords/knowledge-based-scoring","display_name":"knowledge-based scoring","score":0.6460000276565552},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.8593156337738037},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.657291829586029},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.6542314291000366},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.5966660976409912},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5577951669692993},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.5265234708786011},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4775087237358093},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.45780372619628906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44521740078926086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4306914210319519},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4284197688102722},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39775747060775757},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3938778340816498},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37626004219055176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16173055768013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15562307834625244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10382041335105896},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.06327396631240845}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0074053","doi":"https://doi.org/10.1371/journal.pone.0074053","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074053","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074053&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2759622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24023924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24023924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3759441","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3759441/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.7299","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.7299","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/01/pone.0074053.PMC3759441.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b583c5c17ecb45ccb1f8645a180f99eb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b583c5c17ecb45ccb1f8645a180f99eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e74053 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/785920","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Distal_Effect_of_Amino_Acid_Substitutions_in_CYP2C9_Polymorphic_Variants_Causes_Differences_in_Interatomic_Interactions_against_S_Warfarin/785920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.60692/1c3ac-96h60","doi":"https://doi.org/10.60692/1c3ac-96h60","is_oa":true,"landing_page_url":"https://doi.org/10.60692/1c3ac-96h60","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/zd8zz-2zt45","doi":"https://doi.org/10.60692/zd8zz-2zt45","is_oa":true,"landing_page_url":"https://doi.org/10.60692/zd8zz-2zt45","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0074053","doi":"https://doi.org/10.1371/journal.pone.0074053","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074053","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074053&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2683174666","display_name":null,"funder_award_id":"RSA5480026","funder_id":"https://openalex.org/F4320322437","funder_display_name":"National Science and Technology Development Agency"},{"id":"https://openalex.org/G458921967","display_name":"NOVEL PARADIGMS FOR DRUG DISCOVERY: COMPUTATIONAL MULTITARGET SCREENING","funder_award_id":"DP1OD006779","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5791512136","display_name":"Novel Paradigms For Drug Discovery: Computational Multitarget Screening","funder_award_id":"DP1LM011509","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320322401","display_name":"Mahidol University","ror":"https://ror.org/01znkr924"},{"id":"https://openalex.org/F4320322437","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61"},{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333332","display_name":"Office of the Higher Education Commission","ror":"https://ror.org/05m5t2b63"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2094015015.pdf","grobid_xml":"https://content.openalex.org/works/W2094015015.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1498652161","https://openalex.org/W1526205344","https://openalex.org/W1573083715","https://openalex.org/W1882723718","https://openalex.org/W1971721185","https://openalex.org/W1975206909","https://openalex.org/W1985661112","https://openalex.org/W1987375927","https://openalex.org/W1993888853","https://openalex.org/W1999848286","https://openalex.org/W2001968807","https://openalex.org/W2011089905","https://openalex.org/W2013847640","https://openalex.org/W2015403140","https://openalex.org/W2024148791","https://openalex.org/W2025753091","https://openalex.org/W2029327304","https://openalex.org/W2032842297","https://openalex.org/W2032864693","https://openalex.org/W2052696625","https://openalex.org/W2062208322","https://openalex.org/W2065976317","https://openalex.org/W2066252978","https://openalex.org/W2068542260","https://openalex.org/W2073073931","https://openalex.org/W2075151699","https://openalex.org/W2079571096","https://openalex.org/W2080070878","https://openalex.org/W2086191768","https://openalex.org/W2088479888","https://openalex.org/W2094692338","https://openalex.org/W2109453128","https://openalex.org/W2125695618","https://openalex.org/W2135405069","https://openalex.org/W2140049079","https://openalex.org/W2141873118","https://openalex.org/W2150928826","https://openalex.org/W2151936813","https://openalex.org/W2154598050","https://openalex.org/W2156831969","https://openalex.org/W2158534713","https://openalex.org/W2165526004","https://openalex.org/W2311078281"],"related_works":["https://openalex.org/W1971721185","https://openalex.org/W2008002997","https://openalex.org/W4315649092","https://openalex.org/W2079245519","https://openalex.org/W2509702692","https://openalex.org/W2017209503","https://openalex.org/W2325477544","https://openalex.org/W2169635095","https://openalex.org/W1973207178","https://openalex.org/W2107479430"],"abstract_inverted_index":{"Cytochrome":[0],"P450":[1],"2C9":[2],"(CYP2C9)":[3],"is":[4,37],"crucial":[5],"in":[6,14,23,32,39,114,117,143],"excretion":[7],"of":[8,59,69,77,92,125,140,145],"commonly":[9],"prescribed":[10],"drugs.":[11],"However,":[12],"changes":[13],"metabolic":[15],"activity":[16],"caused":[17,46],"by":[18,47],"CYP2C9":[19,78],"polymorphisms":[20],"inevitably":[21],"result":[22],"adverse":[24],"drug":[25,74,146],"effects.":[26],"CYP2C9*2":[27],"and":[28,72,94,98,127],"*3":[29],"are":[30,50],"prevalent":[31],"Caucasian":[33],"populations":[34],"whereas":[35],"CYP2C9*13":[36],"remarkable":[38],"Asian":[40],"populations.":[41],"Single":[42],"amino":[43],"acid":[44],"substitutions":[45],"these":[48,70],"mutations":[49,71],"located":[51],"outside":[52],"catalytic":[53],"cavity":[54],"but":[55],"affect":[56],"kinetic":[57],"activities":[58],"mutants":[60,95],"compared":[61],"to":[62,80,110],"wild-type":[63,93,132],"enzyme.":[64],"To":[65],"relate":[66],"distal":[67],"effects":[68],"defective":[73],"metabolisms,":[75],"simulations":[76],"binding":[79],"anti-coagulant":[81],"(S)-warfarin":[82,107,126],"were":[83,96,108],"performed":[84],"as":[85],"a":[86],"system":[87],"model.":[88],"Representative":[89],"(S)-warfarin-bound":[90],"forms":[91],"sorted":[97],"assessed":[99],"through":[100],"knowledge-based":[101],"scoring":[102],"function.":[103],"Interatomic":[104],"interactions":[105],"towards":[106],"predicted":[109],"be":[111],"less":[112],"favorable":[113],"mutant":[115],"structures":[116],"correlation":[118],"with":[119],"larger":[120],"distance":[121],"between":[122],"hydroxylation":[123],"site":[124],"reactive":[128],"oxyferryl":[129],"heme":[130],"than":[131],"structure.":[133],"Using":[134],"computational":[135],"approach":[136],"could":[137],"delineate":[138],"complication":[139],"CYP":[141],"polymorphism":[142],"management":[144],"therapy.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}