{"id":"https://openalex.org/W2094014355","doi":"https://doi.org/10.2217/fmb.11.13","title":"Epidemiology And Genetics Of VIM-Type Metallo-\u03b2-Lactamases In Gram-Negative Bacilli","display_name":"Epidemiology And Genetics Of VIM-Type Metallo-\u03b2-Lactamases In Gram-Negative Bacilli","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2094014355","doi":"https://doi.org/10.2217/fmb.11.13","mag":"2094014355","pmid":"https://pubmed.ncbi.nlm.nih.gov/21449842"},"language":"en","primary_location":{"id":"doi:10.2217/fmb.11.13","doi":"https://doi.org/10.2217/fmb.11.13","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmb.11.13","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100694249","display_name":"Weihua Zhao","orcid":"https://orcid.org/0000-0002-5672-7132","observed_orcids":["https://orcid.org/0000-0002-5672-7132"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wei-Hua Zhao","raw_affiliation_strings":["Department of Microbiology &amp; Immunology,Showa University School of Medicine,\r          1-5-8 Hatanodai,\r          Shinagawa-ku, Tokyo142\u20138555, Japan","Department of Microbiology & Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan. whzhao@med.showa-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology &amp; Immunology,Showa University School of Medicine,\r          1-5-8 Hatanodai,\r          Shinagawa-ku, Tokyo142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan. whzhao@med.showa-u.ac.jp","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102807718","display_name":"Zhiqing Hu","orcid":"https://orcid.org/0000-0002-3334-2002","observed_orcids":["https://orcid.org/0000-0002-3334-2002"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zhi-Qing Hu","raw_affiliation_strings":["Department of Microbiology &amp; Immunology,Showa University School of Medicine,\r          1-5-8 Hatanodai,\r          Shinagawa-ku, Tokyo142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology &amp; Immunology,Showa University School of Medicine,\r          1-5-8 Hatanodai,\r          Shinagawa-ku, Tokyo142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I119182057"],"apc_list":null,"apc_paid":null,"fwci":0.1912,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.15827338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"3","first_page":"317","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vim-metallo-beta-lactamase","display_name":"VIM metallo-beta-lactamase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gram-negative-bacilli","display_name":"Gram-negative bacilli","score":0.828000009059906},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/class-1-integron","display_name":"class 1 integron","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gene-cassettes","display_name":"gene cassettes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/transposable-elements","display_name":"transposable elements","score":0.7509999871253967},{"id":"https://openalex.org/keywords/plasmids","display_name":"plasmids","score":0.875},{"id":"https://openalex.org/keywords/mobile-genetic-elements","display_name":"mobile genetic elements","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antimicrobial-resistance-dissemination","display_name":"antimicrobial resistance dissemination","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2776650774","wikidata":"https://www.wikidata.org/wiki/Q420197","display_name":"Integron","level":4,"score":0.9392174482345581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7893399596214294},{"id":"https://openalex.org/C132533263","wikidata":"https://www.wikidata.org/wiki/Q2347362","display_name":"Mobile genetic elements","level":4,"score":0.7243459820747375},{"id":"https://openalex.org/C2776870249","wikidata":"https://www.wikidata.org/wiki/Q149128","display_name":"Bacilli","level":3,"score":0.7219053506851196},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.7055172324180603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6733762621879578},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6626178026199341},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5890865325927734},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.498551607131958},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4976342022418976},{"id":"https://openalex.org/C157887575","wikidata":"https://www.wikidata.org/wiki/Q417216","display_name":"Insertion sequence","level":5,"score":0.4860990047454834},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.41321492195129395},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.34606611728668213},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.19038569927215576},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.11951234936714172}],"mesh":[{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016905","descriptor_name":"Gram-Negative Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016905","descriptor_name":"Gram-Negative Bacterial Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032023","descriptor_name":"Integrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/fmb.11.13","doi":"https://doi.org/10.2217/fmb.11.13","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmb.11.13","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},{"id":"pmid:21449842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21449842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318849","display_name":"Showa University","ror":"https://ror.org/04mzk4q39"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W85187135","https://openalex.org/W341343068","https://openalex.org/W1782180540","https://openalex.org/W1783981302","https://openalex.org/W1838378885","https://openalex.org/W1883105101","https://openalex.org/W1886106281","https://openalex.org/W1956017369","https://openalex.org/W1962272194","https://openalex.org/W1965723097","https://openalex.org/W1965948717","https://openalex.org/W1969004546","https://openalex.org/W1972652817","https://openalex.org/W1974892383","https://openalex.org/W1975163873","https://openalex.org/W1980998564","https://openalex.org/W1981645892","https://openalex.org/W1984479212","https://openalex.org/W1989336544","https://openalex.org/W1989796196","https://openalex.org/W1990504694","https://openalex.org/W1991866761","https://openalex.org/W1996858136","https://openalex.org/W1997873483","https://openalex.org/W1998224303","https://openalex.org/W2003301497","https://openalex.org/W2004033347","https://openalex.org/W2005308691","https://openalex.org/W2007638964","https://openalex.org/W2011210667","https://openalex.org/W2013031366","https://openalex.org/W2015518294","https://openalex.org/W2019101967","https://openalex.org/W2019460169","https://openalex.org/W2024989380","https://openalex.org/W2025050250","https://openalex.org/W2030735422","https://openalex.org/W2032094298","https://openalex.org/W2032381873","https://openalex.org/W2035312424","https://openalex.org/W2036758958","https://openalex.org/W2042148774","https://openalex.org/W2044958558","https://openalex.org/W2045850918","https://openalex.org/W2046306037","https://openalex.org/W2048067067","https://openalex.org/W2050112047","https://openalex.org/W2058109762","https://openalex.org/W2058729834","https://openalex.org/W2059330749","https://openalex.org/W2061373808","https://openalex.org/W2067983475","https://openalex.org/W2076101570","https://openalex.org/W2086223988","https://openalex.org/W2089271579","https://openalex.org/W2092329934","https://openalex.org/W2093981951","https://openalex.org/W2095197733","https://openalex.org/W2095747472","https://openalex.org/W2096236685","https://openalex.org/W2097378554","https://openalex.org/W2098232570","https://openalex.org/W2099004335","https://openalex.org/W2099171869","https://openalex.org/W2102941885","https://openalex.org/W2103980635","https://openalex.org/W2105344024","https://openalex.org/W2105862909","https://openalex.org/W2107206868","https://openalex.org/W2109677453","https://openalex.org/W2111188115","https://openalex.org/W2112068555","https://openalex.org/W2112853072","https://openalex.org/W2113555211","https://openalex.org/W2113763076","https://openalex.org/W2114639272","https://openalex.org/W2114832179","https://openalex.org/W2116551606","https://openalex.org/W2116567804","https://openalex.org/W2117536857","https://openalex.org/W2118521954","https://openalex.org/W2121054454","https://openalex.org/W2124556093","https://openalex.org/W2126162495","https://openalex.org/W2126330768","https://openalex.org/W2126734107","https://openalex.org/W2127258317","https://openalex.org/W2129805236","https://openalex.org/W2130882952","https://openalex.org/W2131573558","https://openalex.org/W2134157533","https://openalex.org/W2134810654","https://openalex.org/W2135973654","https://openalex.org/W2136653513","https://openalex.org/W2136690324","https://openalex.org/W2137333677","https://openalex.org/W2138235210","https://openalex.org/W2140563889","https://openalex.org/W2142855469","https://openalex.org/W2143874510","https://openalex.org/W2144178695","https://openalex.org/W2144214931","https://openalex.org/W2145288338","https://openalex.org/W2145578605","https://openalex.org/W2145660300","https://openalex.org/W2146498622","https://openalex.org/W2148298053","https://openalex.org/W2149532802","https://openalex.org/W2157226302","https://openalex.org/W2158301580","https://openalex.org/W2158347878","https://openalex.org/W2159421777","https://openalex.org/W2161822076","https://openalex.org/W2161829383","https://openalex.org/W2162825747","https://openalex.org/W2163564672","https://openalex.org/W2164667941","https://openalex.org/W2164929286","https://openalex.org/W2165213620","https://openalex.org/W2167283992","https://openalex.org/W2169194306","https://openalex.org/W2169796648","https://openalex.org/W2170105571","https://openalex.org/W2171000901","https://openalex.org/W2172070265","https://openalex.org/W2222312033","https://openalex.org/W2326716969","https://openalex.org/W4234903475","https://openalex.org/W4316093169"],"related_works":["https://openalex.org/W2180752492","https://openalex.org/W2616591656","https://openalex.org/W4313494714","https://openalex.org/W7097063727","https://openalex.org/W2172154397","https://openalex.org/W2149532802","https://openalex.org/W1917162549","https://openalex.org/W2008441318","https://openalex.org/W2164667941","https://openalex.org/W4283592232"],"abstract_inverted_index":{"Metallo-\u03b2-lactamases":[0],"(MBLs)":[1],"are":[2,21,66,85,144],"a":[3,69,73],"rapidly":[4],"evolving":[5],"group":[6],"of":[7,23,37,49,62,116,139],"\u03b2-lactamases,":[8],"which":[9],"hydrolyze":[10],"most":[11,25,121],"\u03b2-lactams":[12],"including":[13],"the":[14,17,24,63,112,117,123,137],"carbapenems.":[15],"Of":[16],"known":[18],"MBLs,":[19],"VIMs":[20],"one":[22,128],"common":[26],"families,":[27],"with":[28,57,104,111,127],"27":[29],"variants":[30,51],"detected":[31],"in":[32,88,91,147],"at":[33,105],"least":[34,106],"23":[35],"species":[36],"Gram-negative":[38],"bacilli":[39],"from":[40,53],"more":[41,130],"than":[42],"40":[43],"countries/regions.":[44],"The":[45,83,134],"amino":[46],"acid":[47],"similarities":[48],"VIM":[50],"range":[52],"72.9":[54],"to":[55,77],"99.6%":[56],"1-72":[58],"different":[59,108],"residues.":[60],"Most":[61],"bla":[64,118,124,142],"(VIM)s":[65,125,143],"harbored":[67],"by":[68],"class":[70],"1":[71],"integron,":[72],"genetic":[74],"platform":[75],"able":[76],"acquire":[78],"and":[79,114],"express":[80],"gene":[81],"cassettes.":[82],"integrons":[84],"usually":[86],"embedded":[87],"transposons":[89],"and,":[90],"turn,":[92],"accommodated":[93],"on":[94],"plasmids,":[95],"making":[96],"them":[97],"highly":[98],"mobile.":[99],"Integrons":[100],"display":[101],"considerable":[102],"diversity,":[103],"110":[107],"structures":[109],"associated":[110],"gain":[113],"spread":[115],"(VIM)s.":[119],"In":[120],"instances,":[122],"co-exist":[126],"or":[129],"other":[131],"resistance":[132],"genes.":[133],"processes":[135],"for":[136],"identification":[138],"bacteria":[140],"harboring":[141],"also":[145],"discussed":[146],"this":[148],"article.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
