{"id":"https://openalex.org/W2093945871","doi":"https://doi.org/10.1007/s00253-005-0193-5","title":"Aptamers\u2014basic research, drug development, and clinical applications","display_name":"Aptamers\u2014basic research, drug development, and clinical applications","publication_year":2005,"publication_date":"2005-11-10","ids":{"openalex":"https://openalex.org/W2093945871","doi":"https://doi.org/10.1007/s00253-005-0193-5","mag":"2093945871","pmid":"https://pubmed.ncbi.nlm.nih.gov/16283295"},"language":"en","primary_location":{"id":"doi:10.1007/s00253-005-0193-5","doi":"https://doi.org/10.1007/s00253-005-0193-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00253-005-0193-5","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011921542","display_name":"Daniela Proske","orcid":"https://orcid.org/0009-0009-3950-5907","observed_orcids":["https://orcid.org/0009-0009-3950-5907"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniela Proske","raw_affiliation_strings":["NascaCell IP GmbH, 3. OG, Modul D Max-Lebsche-Platz, 3181377 Munich, Germany. d.proske@nascacell.de","NascaCell IP GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NascaCell IP GmbH, 3. OG, Modul D Max-Lebsche-Platz, 3181377 Munich, Germany. d.proske@nascacell.de","institution_ids":[]},{"raw_affiliation_string":"NascaCell IP GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Blank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Blank","raw_affiliation_strings":["NascaCell IP GmbH, 3. OG, Modul D Max-Lebsche-Platz, 3181377, Munich, Germany","NascaCell IP GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NascaCell IP GmbH, 3. OG, Modul D Max-Lebsche-Platz, 3181377, Munich, Germany","institution_ids":[]},{"raw_affiliation_string":"NascaCell IP GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008003574","display_name":"Raymund Buhmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Raymund Buhmann","raw_affiliation_strings":["GSF\u2014National Research Center for Environment and Health, Munich, Germany","GSF\u2014National Research Center for Environment and Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSF\u2014National Research Center for Environment and Health, Munich, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"GSF\u2014National Research Center for Environment and Health","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020626316","display_name":"Ansgar Resch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ansgar Resch","raw_affiliation_strings":["NascaCell IP GmbH, 3. OG, Modul D Max-Lebsche-Platz, 3181377, Munich, Germany","NascaCell IP GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NascaCell IP GmbH, 3. OG, Modul D Max-Lebsche-Platz, 3181377, Munich, Germany","institution_ids":[]},{"raw_affiliation_string":"NascaCell IP GmbH","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011921542"],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.5725,"has_fulltext":false,"cited_by_count":280,"citation_normalized_percentile":{"value":0.82918579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"69","issue":"4","first_page":"367","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":1.0},{"id":"https://openalex.org/keywords/selex","display_name":"SELEX","score":0.6880000233650208},{"id":"https://openalex.org/keywords/aptamer-selection","display_name":"aptamer selection","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.6629999876022339},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7760000228881836},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.7889999747276306},{"id":"https://openalex.org/keywords/target-validation","display_name":"target validation","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/nucleic-acid-modification","display_name":"nucleic acid modification","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9838211536407471},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.659232497215271},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6391698718070984},{"id":"https://openalex.org/C122682173","wikidata":"https://www.wikidata.org/wiki/Q907101","display_name":"Systematic evolution of ligands by exponential enrichment","level":4,"score":0.6047766804695129},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5140620470046997},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.49138203263282776},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4814414381980896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45742759108543396},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4554573595523834},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.4389660358428955},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3915213644504547},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2441382110118866},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.215192049741745},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.1320146918296814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13151055574417114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0694786012172699},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00253-005-0193-5","doi":"https://doi.org/10.1007/s00253-005-0193-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00253-005-0193-5","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:16283295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16283295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied microbiology and biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W79630512","https://openalex.org/W1556322054","https://openalex.org/W1561712812","https://openalex.org/W1950669782","https://openalex.org/W1964662447","https://openalex.org/W1969650474","https://openalex.org/W1970888712","https://openalex.org/W1970948296","https://openalex.org/W1971204919","https://openalex.org/W1979161806","https://openalex.org/W1979454287","https://openalex.org/W1980585134","https://openalex.org/W1981180126","https://openalex.org/W1992462910","https://openalex.org/W1992817730","https://openalex.org/W1993379751","https://openalex.org/W2004901112","https://openalex.org/W2009035867","https://openalex.org/W2009318927","https://openalex.org/W2013734740","https://openalex.org/W2020115844","https://openalex.org/W2023373190","https://openalex.org/W2029675823","https://openalex.org/W2030522563","https://openalex.org/W2037426832","https://openalex.org/W2038167103","https://openalex.org/W2040839655","https://openalex.org/W2048556894","https://openalex.org/W2051079870","https://openalex.org/W2055457024","https://openalex.org/W2056789539","https://openalex.org/W2057718177","https://openalex.org/W2059884965","https://openalex.org/W2060618183","https://openalex.org/W2063363737","https://openalex.org/W2065480841","https://openalex.org/W2077853597","https://openalex.org/W2078282052","https://openalex.org/W2079321730","https://openalex.org/W2079329107","https://openalex.org/W2080544129","https://openalex.org/W2083384304","https://openalex.org/W2084619201","https://openalex.org/W2087419985","https://openalex.org/W2089985982","https://openalex.org/W2092576784","https://openalex.org/W2092956762","https://openalex.org/W2097535374","https://openalex.org/W2099314656","https://openalex.org/W2101100697","https://openalex.org/W2103311193","https://openalex.org/W2104525153","https://openalex.org/W2109265505","https://openalex.org/W2113976047","https://openalex.org/W2117945149","https://openalex.org/W2120145250","https://openalex.org/W2121364087","https://openalex.org/W2124395350","https://openalex.org/W2134672977","https://openalex.org/W2151014321","https://openalex.org/W2151962921","https://openalex.org/W2256946804","https://openalex.org/W2612281319","https://openalex.org/W2612675835","https://openalex.org/W4239469994","https://openalex.org/W4317640874","https://openalex.org/W7096831481"],"related_works":["https://openalex.org/W2522222091","https://openalex.org/W4415463954","https://openalex.org/W4412607649","https://openalex.org/W2920439209","https://openalex.org/W4392885108","https://openalex.org/W4411442873","https://openalex.org/W2593306046","https://openalex.org/W2106249361","https://openalex.org/W2594952820","https://openalex.org/W2113744409"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
