{"id":"https://openalex.org/W2093725075","doi":"https://doi.org/10.1371/journal.pone.0000700","title":"Homeostatic Plasticity Studied Using In Vivo Hippocampal Activity-Blockade: Synaptic Scaling, Intrinsic Plasticity and Age-Dependence","display_name":"Homeostatic Plasticity Studied Using In Vivo Hippocampal Activity-Blockade: Synaptic Scaling, Intrinsic Plasticity and Age-Dependence","publication_year":2007,"publication_date":"2007-08-07","ids":{"openalex":"https://openalex.org/W2093725075","doi":"https://doi.org/10.1371/journal.pone.0000700","mag":"2093725075","pmid":"https://pubmed.ncbi.nlm.nih.gov/17684547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1933594"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0000700","doi":"https://doi.org/10.1371/journal.pone.0000700","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000700","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000700&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000700&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031396031","display_name":"Julio C. Echegoyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julio Echegoyen","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America. jechegoy@uci.edu","Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America. jechegoy@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057269065","display_name":"Axel Dietmar Neu","orcid":"https://orcid.org/0000-0001-7045-7194","observed_orcids":["https://orcid.org/0000-0001-7045-7194"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Axel Neu","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026144390","display_name":"Kevin Graber","orcid":"https://orcid.org/0000-0002-3094-928X","observed_orcids":["https://orcid.org/0000-0002-3094-928X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin D. Graber","raw_affiliation_strings":["Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054420671","display_name":"Iv\u00e1n Solt\u00e9sz","orcid":"https://orcid.org/0000-0003-1493-3744","observed_orcids":["https://orcid.org/0000-0003-1493-3744"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Soltesz","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California at Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031396031"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.7565,"has_fulltext":true,"cited_by_count":143,"citation_normalized_percentile":{"value":0.94242679,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"2","issue":"8","first_page":"e700","last_page":"e700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeostatic-plasticity","display_name":"homeostatic plasticity","score":0.996999979019165},{"id":"https://openalex.org/keywords/synaptic-scaling","display_name":"synaptic scaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/intrinsic-plasticity","display_name":"intrinsic plasticity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8629999756813049},{"id":"https://openalex.org/keywords/age-dependent-plasticity","display_name":"age-dependent plasticity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/miniature-excitatory-postsynaptic-currents","display_name":"miniature excitatory postsynaptic currents","score":0.8569999933242798},{"id":"https://openalex.org/keywords/miniature-inhibitory-postsynaptic-currents","display_name":"miniature inhibitory postsynaptic currents","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/schaffer-collateral-stimulation","display_name":"Schaffer collateral stimulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/field-response","display_name":"field response","score":0.3970000147819519},{"id":"https://openalex.org/keywords/activity-dependent-development","display_name":"activity-dependent development","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.8630034923553467},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7162682414054871},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.714942991733551},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.6719964742660522},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6006704568862915},{"id":"https://openalex.org/C2778039732","wikidata":"https://www.wikidata.org/wiki/Q7430916","display_name":"Schaffer collateral","level":4,"score":0.5397850275039673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5331361293792725},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4869891107082367},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.46097531914711},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.45175376534461975},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4469364285469055},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4437127113342285},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4425605237483978},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.427891343832016},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.42239853739738464},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4223003387451172},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4149722456932068},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.24975821375846863},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.24830344319343567},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14654728770256042},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12809228897094727},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D026941","descriptor_name":"Sodium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0000700","doi":"https://doi.org/10.1371/journal.pone.0000700","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000700","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000700&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1825283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1933594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1933594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1933594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:17684547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17684547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.9107","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.9107","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2e/76/PLoS_ONE_2007_Aug_8_2(8)_e700.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ff89db6a62524dc98b157573910ee995","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ff89db6a62524dc98b157573910ee995","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 2, Iss 8, p e700 (2007)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt55m2v073","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/55m2v073","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One, vol 2, iss 8","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0000700","doi":"https://doi.org/10.1371/journal.pone.0000700","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000700","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000700&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2665994217","display_name":"PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY","funder_award_id":"R29NS035915","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2690052107","display_name":"Plasticity of GABAergic inhibition following head injury","funder_award_id":"R01NS035915","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G285676165","display_name":null,"funder_award_id":"NS-35915","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4850339041","display_name":"Prevention of Postraumatic Neocortical Epileptogenesis","funder_award_id":"K08NS002167","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5163880993","display_name":null,"funder_award_id":"NS02167","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7146633911","display_name":"Plasticity Of GABAergic Inhibition Following Head Injury","funder_award_id":"R37NS035915","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000170054","display_name":null,"funder_award_id":"NS35915","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2093725075.pdf","grobid_xml":"https://content.openalex.org/works/W2093725075.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W607572140","https://openalex.org/W1482683088","https://openalex.org/W1514853588","https://openalex.org/W1549050411","https://openalex.org/W1568317937","https://openalex.org/W1570032933","https://openalex.org/W1572568267","https://openalex.org/W1647336431","https://openalex.org/W1865428056","https://openalex.org/W1971402245","https://openalex.org/W1971963308","https://openalex.org/W1982292983","https://openalex.org/W1986753855","https://openalex.org/W1988763174","https://openalex.org/W1994896596","https://openalex.org/W1996168091","https://openalex.org/W2001943084","https://openalex.org/W2004803686","https://openalex.org/W2015701831","https://openalex.org/W2026599809","https://openalex.org/W2027699509","https://openalex.org/W2031898618","https://openalex.org/W2036029991","https://openalex.org/W2039655932","https://openalex.org/W2040003929","https://openalex.org/W2052973145","https://openalex.org/W2057717270","https://openalex.org/W2059668389","https://openalex.org/W2063360367","https://openalex.org/W2076837924","https://openalex.org/W2079671310","https://openalex.org/W2080611091","https://openalex.org/W2081847677","https://openalex.org/W2082372907","https://openalex.org/W2087501518","https://openalex.org/W2088426480","https://openalex.org/W2093174501","https://openalex.org/W2094313316","https://openalex.org/W2097965856","https://openalex.org/W2098034531","https://openalex.org/W2098224847","https://openalex.org/W2107257723","https://openalex.org/W2109870708","https://openalex.org/W2114559471","https://openalex.org/W2118625847","https://openalex.org/W2130347268","https://openalex.org/W2141621434","https://openalex.org/W2144126383","https://openalex.org/W2144360649","https://openalex.org/W2151942667","https://openalex.org/W2153220463","https://openalex.org/W2156087438","https://openalex.org/W2158601359","https://openalex.org/W2159380046","https://openalex.org/W2160130055","https://openalex.org/W2302849998","https://openalex.org/W4321429493"],"related_works":["https://openalex.org/W2091116794","https://openalex.org/W3004547756","https://openalex.org/W2082372907","https://openalex.org/W1504868096","https://openalex.org/W7098091300","https://openalex.org/W4405374647","https://openalex.org/W4226198750","https://openalex.org/W4287442312","https://openalex.org/W3015874480","https://openalex.org/W1977219385"],"abstract_inverted_index":{"Homeostatic":[0],"plasticity":[1,37,227],"is":[2,18],"thought":[3],"to":[4,109,176,231],"be":[5],"important":[6],"in":[7,25,38,47,49,61,91,93,100,110,127,143,148,152,177,224],"preventing":[8],"neuronal":[9,159],"circuits":[10],"from":[11,76,170],"becoming":[12],"hyper-":[13],"or":[14],"hypoactive.":[15],"However,":[16,140],"there":[17],"little":[19],"information":[20],"concerning":[21],"homeostatic":[22,107,174,226],"mechanisms":[23,228],"following":[24,42],"vivo":[26,48,62,128,225],"manipulations":[27,112,179],"of":[28,45,69,97,113,126,166,180,195,205],"activity":[29],"levels.":[30],"We":[31],"investigated":[32],"synaptic":[33],"scaling":[34,194],"and":[35,55,150,197,207,210,236],"intrinsic":[36,158],"CA1":[39],"pyramidal":[40],"cells":[41],"2":[43,124],"days":[44,125],"activity-blockade":[46,60],"adult":[50,206,211],"(postnatal":[51],"day":[52],"30;":[53],"P30)":[54],"juvenile":[56,208],"(P15)":[57],"rats.":[58],"Chronic":[59],"was":[63,200],"achieved":[64],"using":[65],"the":[66,70,77,85,141,203],"sustained":[67],"release":[68],"sodium":[71],"channel":[72],"blocker":[73],"tetrodotoxin":[74],"(TTX)":[75],"plastic":[78],"polymer":[79],"Elvax":[80],"40W":[81],"implanted":[82],"directly":[83],"above":[84],"hippocampus,":[86],"followed":[87],"by":[88],"electrophysiological":[89],"assessment":[90],"slices":[92],"vitro.":[94],"Three":[95],"sets":[96,165],"results":[98,167,219],"were":[99,121,138,189,213],"general":[101],"agreement":[102],"with":[103,229],"previous":[104,171],"studies":[105],"on":[106,173],"responses":[108,120,175],"vitro":[111,178],"activity.":[114,181],"First,":[115,182],"Schaffer":[116],"collateral":[117],"stimulation-evoked":[118],"field":[119],"enhanced":[122],"after":[123],"TTX":[129],"application.":[130],"Second,":[131,192],"miniature":[132,183],"excitatory":[133],"postsynaptic":[134,185],"current":[135,186],"(mEPSC)":[136],"amplitudes":[137,145,188,199],"potentiated.":[139],"increase":[142],"mEPSC":[144,196],"occurred":[146],"only":[147],"juveniles,":[149],"not":[151],"adults,":[153],"indicating":[154,215],"age-dependent":[155],"effects.":[156],"Third,":[157,202],"excitability":[160],"increased.":[161],"In":[162],"contrast,":[163],"three":[164],"sharply":[168],"differed":[169],"reports":[172],"inhibitory":[184],"(mIPSC)":[187],"invariably":[190],"enhanced.":[191],"multiplicative":[193],"mIPSC":[198],"absent.":[201],"frequencies":[204],"mEPSCs":[209],"mIPSCs":[212],"increased,":[214],"presynaptic":[216],"alterations.":[217],"These":[218],"provide":[220],"new":[221],"insights":[222],"into":[223],"relevance":[230],"memory":[232],"storage,":[233],"activity-dependent":[234],"development":[235],"neurological":[237],"diseases.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}