{"id":"https://openalex.org/W2093672366","doi":"https://doi.org/10.1038/jcbfm.1994.41","title":"Endothelin Levels Increase in Rat Focal and Global Ischemia","display_name":"Endothelin Levels Increase in Rat Focal and Global Ischemia","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W2093672366","doi":"https://doi.org/10.1038/jcbfm.1994.41","mag":"2093672366","pmid":"https://pubmed.ncbi.nlm.nih.gov/8113329"},"language":"en","primary_location":{"id":"doi:10.1038/jcbfm.1994.41","doi":"https://doi.org/10.1038/jcbfm.1994.41","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.41","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.41","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.41","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083512491","display_name":"Frank C. Barone","orcid":"https://orcid.org/0000-0001-8509-3936","observed_orcids":["https://orcid.org/0000-0001-8509-3936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. C. Barone","raw_affiliation_strings":["Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]},{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110059573","display_name":"M. Y. -T. Globus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Y.-T. Globus","raw_affiliation_strings":["Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074090137","display_name":"William J. Price","orcid":"https://orcid.org/0000-0002-4989-6333","observed_orcids":["https://orcid.org/0000-0002-4989-6333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. J. Price","raw_affiliation_strings":["Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. F. White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. F. White","raw_affiliation_strings":["Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524845","display_name":"Barbara L. Storer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. L. Storer","raw_affiliation_strings":["Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110028885","display_name":"G. Z. FEUERSTEIN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Z. Feuerstein","raw_affiliation_strings":["Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111641213","display_name":"Raul Busto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Busto","raw_affiliation_strings":["Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Florida, U.S.A","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035875588","display_name":"Eliot H. Ohlstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. H. Ohlstein","raw_affiliation_strings":["Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":8.8007,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.98569431,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"2","first_page":"337","last_page":"342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bilateral-common-carotid-artery-occlusion","display_name":"bilateral common carotid artery occlusion","score":0.878000020980835},{"id":"https://openalex.org/keywords/cerebral-vasospasm","display_name":"cerebral vasospasm","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.7369999885559082},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ischemic-brain-tissue","display_name":"ischemic brain tissue","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.846555769443512},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7484408020973206},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.7176535129547119},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.6403113007545471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5813218951225281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5635245442390442},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5447860360145569},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.5334781408309937},{"id":"https://openalex.org/C2778506911","wikidata":"https://www.wikidata.org/wiki/Q2849606","display_name":"Vasospasm","level":3,"score":0.512535810470581},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5026347637176514},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.4845937490463257},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4594150483608246},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.43121740221977234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20893657207489014},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1922180950641632},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.13140639662742615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059997230768203735},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0566064715385437}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015424","descriptor_name":"Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/jcbfm.1994.41","doi":"https://doi.org/10.1038/jcbfm.1994.41","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.41","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.41","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:8113329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8113329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/jcbfm.1994.41","doi":"https://doi.org/10.1038/jcbfm.1994.41","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.41","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.41","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G130134820","display_name":null,"funder_award_id":"NS-05820","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2198807715","display_name":null,"funder_award_id":"85-23","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3323753248","display_name":null,"funder_award_id":"85-23","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8558760249","display_name":null,"funder_award_id":"MD 20205","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2093672366.pdf","grobid_xml":"https://content.openalex.org/works/W2093672366.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1515487220","https://openalex.org/W1588320719","https://openalex.org/W1775749144","https://openalex.org/W1874649057","https://openalex.org/W1968772869","https://openalex.org/W1976046184","https://openalex.org/W1977162373","https://openalex.org/W1978813311","https://openalex.org/W1980762198","https://openalex.org/W1982892406","https://openalex.org/W1988808856","https://openalex.org/W1989014567","https://openalex.org/W1989314580","https://openalex.org/W1991477995","https://openalex.org/W1993192780","https://openalex.org/W1994386552","https://openalex.org/W1996770463","https://openalex.org/W1997228176","https://openalex.org/W1998472359","https://openalex.org/W2006399633","https://openalex.org/W2017475630","https://openalex.org/W2024380592","https://openalex.org/W2029847521","https://openalex.org/W2031773044","https://openalex.org/W2034290120","https://openalex.org/W2041682797","https://openalex.org/W2048597281","https://openalex.org/W2049209816","https://openalex.org/W2053341561","https://openalex.org/W2055588106","https://openalex.org/W2056356536","https://openalex.org/W2060117625","https://openalex.org/W2060847787","https://openalex.org/W2061708109","https://openalex.org/W2071839909","https://openalex.org/W2080562431","https://openalex.org/W2080656191","https://openalex.org/W2081044378","https://openalex.org/W2081976643","https://openalex.org/W2082579842","https://openalex.org/W2082686123","https://openalex.org/W2086751397","https://openalex.org/W2088073681","https://openalex.org/W2121306155","https://openalex.org/W2125683177","https://openalex.org/W2131602566","https://openalex.org/W2140758343","https://openalex.org/W2162804111","https://openalex.org/W2167915117","https://openalex.org/W2172113665","https://openalex.org/W2204155721","https://openalex.org/W2321309748","https://openalex.org/W2336208433","https://openalex.org/W2400305401","https://openalex.org/W2412344370","https://openalex.org/W2434713954"],"related_works":["https://openalex.org/W2009206883","https://openalex.org/W2059086113","https://openalex.org/W2408875707","https://openalex.org/W2111983313","https://openalex.org/W2419306832","https://openalex.org/W2439927901","https://openalex.org/W2182720295","https://openalex.org/W2085901947","https://openalex.org/W2374235458","https://openalex.org/W2080331928"],"abstract_inverted_index":{"Endothelin-1,":[0],"a":[1,148,182,241],"peptide":[2,245],"exhibiting":[3],"extremely":[4],"potent":[5],"cerebral":[6,21,61,100,252],"vasoactive":[7],"properties,":[8],"is":[9,218],"elevated":[10,223],"in":[11,20,32,34,48,72,125,147,156,159,177,227,232,236,246],"the":[12,95,103,126,160,171,205,219,233,244],"cerebrospinal":[13],"fluid":[14,75,235],"after":[15,82,94],"hemorrhagic":[16],"stroke":[17],"and":[18,42,81,193,200,213,231,239,248,255],"implicated":[19],"vasospasm.":[22],"The":[23],"purpose":[24],"of":[25,97,112,173,185,222,225,243,251],"this":[26],"study":[27],"was":[28,64,115],"to":[29,189],"determine":[30],"changes":[31,203],"endothelin":[33,40,46,68,114,158,175,226],"ischemic":[35,49,104,161,229,247],"rat":[36],"brain":[37,50],"by":[38,59,77,86,121],"assaying":[39],"tissue":[41,51,230,256],"extracellular":[43,74,208,234],"levels.":[44],"Immunoreactive":[45],"levels":[47,69,224],"following":[52,214],"permanent":[53,98],"or":[54],"transient":[55],"focal":[56,228],"ischemia":[57,84,165,212,238],"produced":[58,85],"middle":[60,99],"artery":[62,101,135],"occlusion":[63,88,136],"determined.":[65],"In":[66],"addition,":[67],"were":[70],"assayed":[71],"striatal":[73,178],"collected":[76,176],"microdialysis":[78,179],"before,":[79],"during,":[80],"global":[83,237],"two-vessel":[87],"combined":[89],"with":[90,140],"hypotension.":[91],"Twenty-four":[92],"hours":[93],"onset":[96],"occlusion,":[102],"cortex":[105,128],"level":[106,172,184],"(0.58":[107],"+/-":[108,130,187,191,195],"0.27":[109],"fmol/mg":[110,132],"protein)":[111],"immunoreactive":[113,157,174],"significantly":[116,166],"(p":[117,151,167],"<":[118,152,168],"0.05)":[119,153,169],"increased,":[120],"100%,":[122],"over":[123],"that":[124],"nonischemic":[127],"(0.29":[129],"0.13":[131],"protein).":[133],"Transient":[134],"for":[137,142],"80":[138],"min":[139],"reperfusion":[141],"24":[143],"h":[144],"also":[145],"resulted":[146],"similar":[149],"significant":[150],"increase,":[154],"78%,":[155],"zone.":[162],"Global":[163],"forebrain":[164],"increased":[170],"perfusate,":[180],"from":[181],"basal":[183],"14.6":[186],"6.7":[188],"26.5":[190],"7.7":[192],"26.2":[194],"7.4":[196],"amol/microliters":[197],"(i.e.":[198],"82":[199],"79%).":[201],"These":[202],"reflect":[204],"relative":[206],"picomolar":[207],"concentration":[209],"increases":[210],"during":[211],"reperfusion,":[215],"respectively.":[216],"This":[217],"first":[220],"demonstration":[221],"suggests":[240],"role":[242],"postischemic":[249],"derangements":[250],"vascular":[253],"function":[254],"injury.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}