{"id":"https://openalex.org/W2093662767","doi":"https://doi.org/10.1161/01.atv.9.3.405","title":"Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins.","display_name":"Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins.","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2093662767","doi":"https://doi.org/10.1161/01.atv.9.3.405","mag":"2093662767","pmid":"https://pubmed.ncbi.nlm.nih.gov/2719600"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.9.3.405","doi":"https://doi.org/10.1161/01.atv.9.3.405","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.9.3.405","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1161/01.atv.9.3.405","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041998046","display_name":"Armin Steinmetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Steinmetz","raw_affiliation_strings":["Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001782922","display_name":"C. Jakobs","orcid":"https://orcid.org/0009-0008-0640-3798","observed_orcids":["https://orcid.org/0009-0008-0640-3798"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Jakobs","raw_affiliation_strings":["Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014547708","display_name":"Sabine Motzny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Motzny","raw_affiliation_strings":["Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012303264","display_name":"H. Kaffarnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Kaffarnik","raw_affiliation_strings":["Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universit\u00e4t, Marburg, West Germany","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161103922"],"apc_list":null,"apc_paid":null,"fwci":4.9923,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.95335406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"405","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9580000042915344},{"id":"https://openalex.org/keywords/apolipoprotein-e-isoforms","display_name":"apolipoprotein E isoforms","score":0.9129999876022339},{"id":"https://openalex.org/keywords/plasma-lipoproteins","display_name":"serum lipoproteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.8519999980926514},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cholesterol-levels","display_name":"cholesterol levels","score":0.6420000195503235},{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7260194420814514},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7067684531211853},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.6703450679779053},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5908575654029846},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.522881031036377},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.5051363110542297},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.49449583888053894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4904443919658661},{"id":"https://openalex.org/C54689828","wikidata":"https://www.wikidata.org/wiki/Q2029259","display_name":"Ultracentrifuge","level":2,"score":0.4209533631801605},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41515886783599854},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4094931185245514},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40642616152763367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40580490231513977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32880866527557373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3005928099155426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09778779745101929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0892939567565918},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.atv.9.3.405","doi":"https://doi.org/10.1161/01.atv.9.3.405","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.9.3.405","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},{"id":"pmid:2719600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2719600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis (Dallas, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.631.6780","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.631.6780","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/9/3/405.full.pdf","raw_type":"text"},{"id":"mag:3139722952","doi":null,"is_oa":true,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atv81.9.3.2719600?related-urls=yes&legid=atvbaha%3B9%2F3%2F405","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.atv.9.3.405","doi":"https://doi.org/10.1161/01.atv.9.3.405","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.9.3.405","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W16538605","https://openalex.org/W171150731","https://openalex.org/W182198897","https://openalex.org/W1486483271","https://openalex.org/W1577502861","https://openalex.org/W1736154854","https://openalex.org/W1980407853","https://openalex.org/W1983271161","https://openalex.org/W1985191197","https://openalex.org/W1990170200","https://openalex.org/W1999629767","https://openalex.org/W2003854546","https://openalex.org/W2029877157","https://openalex.org/W2039158755","https://openalex.org/W2062201648","https://openalex.org/W2066337406","https://openalex.org/W2067050771","https://openalex.org/W2071115881","https://openalex.org/W2085649019","https://openalex.org/W2090509830","https://openalex.org/W2101108802","https://openalex.org/W2118043862","https://openalex.org/W2125376196","https://openalex.org/W2160006134","https://openalex.org/W2166648967","https://openalex.org/W2259265492","https://openalex.org/W2272070467","https://openalex.org/W2313768139"],"related_works":["https://openalex.org/W7097885566","https://openalex.org/W2155559959","https://openalex.org/W2186590314","https://openalex.org/W1841798962","https://openalex.org/W1996342912","https://openalex.org/W171150731","https://openalex.org/W2000991693","https://openalex.org/W2080889607","https://openalex.org/W2040832487","https://openalex.org/W2489484868"],"abstract_inverted_index":{"The":[0,21],"polymorphism":[1],"of":[2,12,16,49,65,106,120,134,173],"apolipoprotein":[3],"E":[4,99,142,159],"(apo":[5],"E)":[6],"accounts":[7],"for":[8,201],"a":[9,188],"substantial":[10],"amount":[11],"the":[13,25,39,43,50,61,69,79,97,145,204],"genetic":[14],"variance":[15],"cholesterol":[17,34,45],"levels":[18,35,46],"in":[19,47,56,111,132,164,193,203],"man.":[20],"epsilon-2":[22,51],"allele":[23,27,52],"and":[24,30,75,86,91,114,184,209],"epsilon-4":[26],"raises":[28],"plasma":[29,133,163],"low":[31],"density":[32,108,116,175],"lipoprotein":[33,190,197],"as":[36,123],"compared":[37,124],"to":[38,60,68,78,88,95,125],"epsilon-3":[40],"allele.":[41],"Whereas":[42],"lower":[44,107,174],"carriers":[48],"can,":[53],"at":[54],"least":[55],"part,":[57],"be":[58],"attributed":[59],"grossly":[62],"deficient":[63],"binding":[64],"apo":[66,70,73,98,112,121,126,141,146,158,166,177,182,185,207],"E-2":[67],"B,E":[71],"receptor,":[72],"E-3":[74,183,208],"E-4":[76,113,122,167,186],"bind":[77],"same":[80],"degree.":[81],"We":[82,102,179],"used":[83],"gel":[84],"filtration":[85],"ultracentrifugation":[87],"separate":[89],"lipoproteins":[90,105,117,172],"subsequent":[92],"immunoblotting":[93],"analysis":[94],"study":[96],"isoform":[100],"distribution.":[101],"always":[103],"found":[104],"relatively":[109,118],"enriched":[110],"high":[115],"depleted":[119],"E-3.":[127,178],"This":[128,195],"was":[129,149,160],"also":[130,168],"seen":[131],"heterozygous":[135],"subjects":[136],"that":[137,181],"simultaneously":[138],"express":[139],"two":[140],"isoforms.":[143],"Also,":[144],"E-A-II":[147],"complex":[148],"directly":[150],"shown":[151],"by":[152],"immunoblotting.":[153],"Furthermore,":[154],"when":[155],"purified":[156],"iodinated":[157],"incubated":[161],"with":[162,171],"vitro,":[165],"reassociated":[169],"more":[170],"than":[176],"conclude":[180],"have":[187],"different":[189],"particle":[191],"distribution":[192,198],"vivo.":[194],"differential":[196],"may":[199],"account":[200],"differences":[202],"metabolism":[205],"between":[206],"E-4.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}