{"id":"https://openalex.org/W2093645284","doi":"https://doi.org/10.1093/intimm/4.3.387","title":"IL-4-induced expression of germline \u03b31 transcripts in B cells following cognate interactions with T helper cells","display_name":"IL-4-induced expression of germline \u03b31 transcripts in B cells following cognate interactions with T helper cells","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2093645284","doi":"https://doi.org/10.1093/intimm/4.3.387","mag":"2093645284","pmid":"https://pubmed.ncbi.nlm.nih.gov/1373644"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/4.3.387","doi":"https://doi.org/10.1093/intimm/4.3.387","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/4.3.387","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036405811","display_name":"Michael T. Berton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Berton","raw_affiliation_strings":["Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111421162","display_name":"Ellen S. Vitetta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ellen S. Vitetta","raw_affiliation_strings":["Department of Microbiology, University of Texas Southwester Medical Center 5323 Harry Hines Boulevard, Dallas, TX 75235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Texas Southwester Medical Center 5323 Harry Hines Boulevard, Dallas, TX 75235, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111421162"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":0.6444,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68534044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"4","issue":"3","first_page":"387","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8510000109672546},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.828000009059906},{"id":"https://openalex.org/keywords/igg1","display_name":"IgG1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.734000027179718},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8809999823570251},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.7657736539840698},{"id":"https://openalex.org/C137756551","wikidata":"https://www.wikidata.org/wiki/Q2386881","display_name":"Immunoglobulin class switching","level":4,"score":0.7366455793380737},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.7171844840049744},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5869607925415039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5104488134384155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4948388934135437},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4947149455547333},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4689604341983795},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4446471929550171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32733267545700073},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3170315623283386},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3091135323047638},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2941232919692993},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23761379718780518},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1798572540283203},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16313177347183228},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.12248054146766663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007134","descriptor_name":"Immunoglobulin Switch Region","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007142","descriptor_name":"Immunoglobulin gamma-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008211","descriptor_name":"Lymphocyte Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/intimm/4.3.387","doi":"https://doi.org/10.1093/intimm/4.3.387","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/4.3.387","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmid:1373644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1373644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1621934318","display_name":"THE ACTIVATION OF ANTIGEN-SPECIFIC B CELLS","funder_award_id":"5r01ai021229-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3500732594","display_name":"MECHANISM OF ISOTYPE SWITCHING IN MURINE B LYMPHOCYTES","funder_award_id":"1f32ai007945-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G529281106","display_name":"ACTIVATION AND DIFFERENTIATION OF LYMPHOCYTES","funder_award_id":"2p01ai011851-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6617782734","display_name":null,"funder_award_id":"AI-21229","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6629344325","display_name":null,"funder_award_id":"AI07945","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G961486399","display_name":null,"funder_award_id":"AI11851","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1598680328","https://openalex.org/W7062341892","https://openalex.org/W2096287486","https://openalex.org/W2000637851","https://openalex.org/W4313376941","https://openalex.org/W1844578396","https://openalex.org/W2066132051","https://openalex.org/W2104149513","https://openalex.org/W2167871255","https://openalex.org/W2225120452"],"abstract_inverted_index":{"T":[0,18,86,191,199],"cell-dependent":[1],"B":[2,23,56,119,138,193],"cell":[3,47,87,200],"activation":[4],"and":[5,13,89,117,165,192],"the":[6,28,41,45,71,83,97,101,109,157,169,173,205],"induction":[7],"of":[8,30,34,53,73,85,103,111,132,143,172,182,207],"isotype":[9,63,92,104],"switching":[10,64,105],"require":[11],"antigen":[12],"direct":[14,188],"contact":[15,88,189],"with":[16,48,156],"helper":[17],"(Th)":[19],"cells.":[20,120,139],"During":[21],"activation,":[22],"cells":[24,57,116,125,151,194],"can":[25,129],"switch":[26,79,208],"from":[27],"expression":[29,131,181],"IgM":[31],"to":[32,77,106],"that":[33,60,69,123,126],"IgG,":[35],"IgE":[36],"or":[37,163],"IgA,":[38],"depending":[39],"on":[40],"lymphokines":[42,61,90],"secreted":[43],"by":[44,149,160],"Th":[46,115],"which":[49],"they":[50],"interact.":[51],"Studies":[52],"lipopolysaccharide":[54],"(LPS)-activated":[55],"have":[58,95],"suggested":[59],"regulate":[62],"via":[65],"a":[66,78,196],"transcriptional":[67],"mechanism":[68],"increases":[70],"accessibility":[72,98,206],"downstream":[74],"CH":[75],"genes":[76],"recombinase(s).":[80],"To":[81],"assess":[82],"roles":[84],"in":[91,108,137,203],"switching,":[93],"we":[94],"examined":[96],"model":[99],"for":[100,198],"regulation":[102],"IgG1":[107],"context":[110],"cognate":[112],"interactions":[113],"between":[114,190],"normal":[118],"We":[121],"demonstrate":[122],"Th2":[124,150],"secrete":[127],"IL-4":[128,161],"induce":[130],"germline":[133,144,174,183],"gamma":[134,145,175,184],"1":[135,146,176,185],"transcripts":[136,147,186],"The":[140],"steady-state":[141],"level":[142,158],"induced":[148,159],"is":[152],"enhanced":[153],"as":[154],"compared":[155],"alone":[162],"Il-4":[164],"LPS":[166],"also":[167],"alters":[168],"relative":[170],"usage":[171],"transcription":[177],"initiation":[178],"sites.":[179],"Enhanced":[180],"requires":[187],"suggesting":[195],"role":[197],"contact-mediated":[201],"signals":[202],"regulating":[204],"regions.":[209]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
