{"id":"https://openalex.org/W2093643128","doi":"https://doi.org/10.1021/jo047782p","title":"@-Tide-Stabilized \u03b2-Hairpins","display_name":"@-Tide-Stabilized \u03b2-Hairpins","publication_year":2005,"publication_date":"2005-02-09","ids":{"openalex":"https://openalex.org/W2093643128","doi":"https://doi.org/10.1021/jo047782p","mag":"2093643128","pmid":"https://pubmed.ncbi.nlm.nih.gov/15730311"},"language":"en","primary_location":{"id":"doi:10.1021/jo047782p","doi":"https://doi.org/10.1021/jo047782p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo047782p","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017427019","display_name":"Scott T. Phillips","orcid":"https://orcid.org/0000-0001-5262-6206","observed_orcids":["https://orcid.org/0000-0001-5262-6206"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T. Phillips","raw_affiliation_strings":["Center for New Directions in Organic Synthesis,\u2020 Department of Chemistry, University of California, Berkeley, California 94720-1460","Center for New Directions in Organic Synthesis Department of Chemistry, University of California, Berkeley, California 94720-1460, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for New Directions in Organic Synthesis,\u2020 Department of Chemistry, University of California, Berkeley, California 94720-1460","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Center for New Directions in Organic Synthesis Department of Chemistry, University of California, Berkeley, California 94720-1460, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037583772","display_name":"Landy K. Blasdel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Landy K. Blasdel","raw_affiliation_strings":["Center for New Directions in Organic Synthesis,\u2020 Department of Chemistry, University of California, Berkeley, California 94720-1460"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for New Directions in Organic Synthesis,\u2020 Department of Chemistry, University of California, Berkeley, California 94720-1460","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103463683","display_name":"Paul A. Bartlett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Bartlett","raw_affiliation_strings":["Center for New Directions in Organic Synthesis,\u2020 Department of Chemistry, University of California, Berkeley, California 94720-1460"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for New Directions in Organic Synthesis,\u2020 Department of Chemistry, University of California, Berkeley, California 94720-1460","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.004,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.72712611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"70","issue":"5","first_page":"1865","last_page":"1871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.041999999433755875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-hairpin","display_name":"beta-hairpin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.777999997138977},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.546999990940094},{"id":"https://openalex.org/keywords/beta-sheet-stabilization","display_name":"\u03b2-sheet stabilization","score":0.6449999809265137},{"id":"https://openalex.org/keywords/beta-turn","display_name":"beta-turn","score":0.7400000095367432},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/solvent-effects-on-conformation","display_name":"solvent effects on conformation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nmr-spectroscopy","display_name":"NMR spectroscopy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9670683145523071}],"mesh":[{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jo047782p","doi":"https://doi.org/10.1021/jo047782p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo047782p","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:15730311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15730311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W652646270","https://openalex.org/W1487590544","https://openalex.org/W1966596430","https://openalex.org/W1975146156","https://openalex.org/W1975877608","https://openalex.org/W1978314665","https://openalex.org/W1988184759","https://openalex.org/W2011153657","https://openalex.org/W2026946969","https://openalex.org/W2028856123","https://openalex.org/W2040560905","https://openalex.org/W2043343021","https://openalex.org/W2052671506","https://openalex.org/W2062128131","https://openalex.org/W2062714484","https://openalex.org/W2062928804","https://openalex.org/W2066946197","https://openalex.org/W2088848851","https://openalex.org/W2092158154","https://openalex.org/W2155767442","https://openalex.org/W2155921797","https://openalex.org/W2157906773","https://openalex.org/W2163999571","https://openalex.org/W2943034305","https://openalex.org/W2949250147","https://openalex.org/W2952838135","https://openalex.org/W4249649290"],"related_works":["https://openalex.org/W2104634000","https://openalex.org/W2130296175","https://openalex.org/W2126197455","https://openalex.org/W2311862142","https://openalex.org/W7073704037","https://openalex.org/W2002630515","https://openalex.org/W2950422986","https://openalex.org/W2035314378","https://openalex.org/W2585980515","https://openalex.org/W2065359898"],"abstract_inverted_index":{"As":[0],"minimalist":[1],"versions":[2],"of":[3,27,58,101,104,113],"beta-structure,":[4],"two-stranded":[5],"beta-hairpins":[6,66],"are":[7],"commonly":[8],"employed":[9],"as":[10,33],"platforms":[11],"for":[12],"assessing":[13],"the":[14,25,39,54,62,71,82,99,108],"interactions":[15],"that":[16,24],"stabilize":[17],"beta-sheets":[18,69],"in":[19,77,116],"proteins.":[20],"We":[21],"have":[22],"found":[23],"presence":[26],"a":[28,50,78,86,90,102],"1,6-dihydro-3(2H)-pyridinone":[29],"moiety":[30],"(the":[31],"\"@-unit\")":[32],"an":[34],"amino":[35,92],"acid":[36],"replacement":[37],"at":[38],"i":[40,44],"-":[41],"1":[42],"or":[43],"+":[45],"4":[46],"positions":[47],"relative":[48],"to":[49,85],"beta-turn":[51],"strongly":[52],"stabilizes":[53],"hairpin":[55,83],"conformation.":[56],"Hybrids":[57],"this":[59,95],"type":[60],"bridge":[61],"gap":[63],"between":[64],"natural":[65],"and":[67,107,110,119],"unnatural":[68],"because":[70],"@-unit":[72],"only":[73],"replaces":[74],"one":[75],"residue":[76],"peptide":[79],"while":[80],"stabilizing":[81],"conformation":[84],"greater":[87],"extent":[88],"than":[89],"normal":[91],"acid.":[93],"In":[94],"report,":[96],"we":[97],"describe":[98],"synthesis":[100],"variety":[103],"@-tide-templated":[105],"hairpins":[106],"NMR":[109],"CD":[111],"characterization":[112],"their":[114],"conformations":[115],"both":[117],"polar":[118],"nonpolar":[120],"solvents.":[121]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}