{"id":"https://openalex.org/W2093626313","doi":"https://doi.org/10.1126/science.278.5345.1943","title":"Crystal Structure of the Adenylyl Cyclase Activator G s \u03b1","display_name":"Crystal Structure of the Adenylyl Cyclase Activator G s \u03b1","publication_year":1997,"publication_date":"1997-12-12","ids":{"openalex":"https://openalex.org/W2093626313","doi":"https://doi.org/10.1126/science.278.5345.1943","mag":"2093626313","pmid":"https://pubmed.ncbi.nlm.nih.gov/9395396"},"language":"en","primary_location":{"id":"doi:10.1126/science.278.5345.1943","doi":"https://doi.org/10.1126/science.278.5345.1943","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.278.5345.1943","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006646972","display_name":"Roger K. Sunahara","orcid":"https://orcid.org/0000-0003-1702-8619","observed_orcids":["https://orcid.org/0000-0003-1702-8619"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger K. Sunahara","raw_affiliation_strings":["J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037144273","display_name":"John J. G. Tesmer","orcid":"https://orcid.org/0000-0003-1125-3727","observed_orcids":["https://orcid.org/0000-0003-1125-3727"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. G. Tesmer","raw_affiliation_strings":["J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054552947","display_name":"Alfred G. Gilman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred G. Gilman","raw_affiliation_strings":["J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056991064","display_name":"Stephen R. Sprang","orcid":"https://orcid.org/0000-0001-6307-6166","observed_orcids":["https://orcid.org/0000-0001-6307-6166"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen R. Sprang","raw_affiliation_strings":["J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. J. G.Tesmer and S. R. Sprang, Howard Hughes Medical Institute and the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139050, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"R. K. Sunahara and A. G. Gilman, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235\u20139041, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056991064"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":4.8626,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.96487867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"278","issue":"5345","first_page":"1943","last_page":"1947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gs-protein","display_name":"Gs protein","score":0.8790000081062317},{"id":"https://openalex.org/keywords/heterotrimeric-g-proteins","display_name":"heterotrimeric G proteins","score":0.871999979019165},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/effector-specificity","display_name":"effector specificity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/regulators-of-g-protein-signaling","display_name":"regulator of G protein signaling","score":0.8220000267028809},{"id":"https://openalex.org/keywords/receptor-specificity","display_name":"receptor specificity","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.9115791320800781},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.7935057878494263},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.7815770506858826},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.6790202856063843},{"id":"https://openalex.org/C176303035","wikidata":"https://www.wikidata.org/wiki/Q5513929","display_name":"Gs alpha subunit","level":4,"score":0.6655763387680054},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5288549065589905},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.5286888480186462},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45569247007369995},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.445970356464386},{"id":"https://openalex.org/C78254988","wikidata":"https://www.wikidata.org/wiki/Q22328498","display_name":"G beta-gamma complex","level":5,"score":0.42747819423675537},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.41220661997795105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37348097562789917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36511707305908203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3285273313522339},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2367362082004547},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08289539813995361}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019206","descriptor_name":"GTP-Binding Protein alpha Subunits, Gi-Go","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019206","descriptor_name":"GTP-Binding Protein alpha Subunits, Gi-Go","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.278.5345.1943","doi":"https://doi.org/10.1126/science.278.5345.1943","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.278.5345.1943","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9395396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9395396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.umt.edu:biosci_pubs-1539","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umt.edu/biosci_pubs/536","pdf_url":null,"source":{"id":"https://openalex.org/S190740074","display_name":"The Mathematics Enthusiast","issn_l":"1551-3440","issn":["1551-3440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biological Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7946204254","display_name":null,"funder_award_id":"DK46371","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G976133492","display_name":null,"funder_award_id":"GM 34497","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W50079648","https://openalex.org/W1517746500","https://openalex.org/W1562025403","https://openalex.org/W1586297894","https://openalex.org/W1627554898","https://openalex.org/W1942777601","https://openalex.org/W1972038609","https://openalex.org/W1975316279","https://openalex.org/W1979035442","https://openalex.org/W1981558627","https://openalex.org/W1984212762","https://openalex.org/W1986191025","https://openalex.org/W1990401009","https://openalex.org/W1993466966","https://openalex.org/W2013083986","https://openalex.org/W2022754746","https://openalex.org/W2024296404","https://openalex.org/W2025818505","https://openalex.org/W2027234006","https://openalex.org/W2030185192","https://openalex.org/W2031351133","https://openalex.org/W2041756859","https://openalex.org/W2044716499","https://openalex.org/W2045198466","https://openalex.org/W2060448324","https://openalex.org/W2071242185","https://openalex.org/W2080476827","https://openalex.org/W2080875376","https://openalex.org/W2090399899","https://openalex.org/W2106315897","https://openalex.org/W2114460420","https://openalex.org/W2136906322","https://openalex.org/W2144001627","https://openalex.org/W2147302733","https://openalex.org/W2153785468"],"related_works":["https://openalex.org/W1993214280","https://openalex.org/W4244999412","https://openalex.org/W1972038609","https://openalex.org/W2027234006","https://openalex.org/W1627554898","https://openalex.org/W2065274807","https://openalex.org/W7036949777","https://openalex.org/W2147422686","https://openalex.org/W2093742326","https://openalex.org/W1969583788"],"abstract_inverted_index":{"The":[0,111],"crystal":[1],"structure":[2,51,123],"of":[3,32,35,42,49,52,56,69,88,98,100,109,115,126],"Gsalpha,":[4],"the":[5,29,40,50,67,70,75,80,84,96,106,131,135,139],"heterotrimeric":[6],"G":[7,101],"protein":[8,102],"alpha":[9],"subunit":[10],"that":[11,38,55,59,125],"stimulates":[12],"adenylyl":[13],"cyclase,":[14],"was":[15],"determined":[16],"at":[17],"2.5":[18],"A":[19],"in":[20,44,120,130],"a":[21,33,45],"complex":[22],"with":[23,54],"guanosine":[24],"5'-O-(3-thiotriphosphate)":[25],"(GTPgammaS).":[26],"Gsalpha":[27,116],"is":[28,63,117],"prototypic":[30],"member":[31],"family":[34],"GTP-binding":[36],"proteins":[37],"regulate":[39],"activities":[41],"effectors":[43],"hormone-dependent":[46],"manner.":[47],"Comparison":[48],"Gsalpha.GTPgammaS":[53],"Gialpha.GTPgammaS":[57],"suggests":[58],"their":[60],"effector":[61],"specificity":[62],"primarily":[64],"dictated":[65],"by":[66,74,134],"shape":[68],"binding":[71,113],"surface":[72,114,132],"formed":[73,133],"switch":[76],"II":[77],"helix":[78,137],"and":[79,122,138],"alpha3-beta5":[81],"loop,":[82],"despite":[83],"high":[85],"sequence":[86,93,121],"homology":[87],"these":[89],"elements.":[90],"In":[91],"contrast,":[92],"divergence":[94],"explains":[95],"inability":[97],"regulators":[99],"signaling":[103],"to":[104,124],"stimulate":[105],"GTPase":[107],"activity":[108],"Gsalpha.":[110],"betagamma":[112],"largely":[118],"conserved":[119],"Gialpha,":[127],"whereas":[128],"differences":[129],"carboxyl-terminal":[136],"alpha4-beta6":[140],"loop":[141],"may":[142],"mediate":[143],"receptor":[144],"specificity.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}