{"id":"https://openalex.org/W2093613636","doi":"https://doi.org/10.1186/1742-4690-8-s1-a202","title":"Human T-lymphotropic virus type 1 p30 interacts with REG\u03b3 and ATM (Ataxia Telangiectasia Mutated) to promote cell survival","display_name":"Human T-lymphotropic virus type 1 p30 interacts with REG\u03b3 and ATM (Ataxia Telangiectasia Mutated) to promote cell survival","publication_year":2011,"publication_date":"2011-06-06","ids":{"openalex":"https://openalex.org/W2093613636","doi":"https://doi.org/10.1186/1742-4690-8-s1-a202","mag":"2093613636"},"language":"en","primary_location":{"id":"doi:10.1186/1742-4690-8-s1-a202","doi":"https://doi.org/10.1186/1742-4690-8-s1-a202","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-8-s1-a202","pdf_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/1742-4690-8-S1-A202","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/1742-4690-8-S1-A202","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064093687","display_name":"Rajaneesh Anupam","orcid":"https://orcid.org/0000-0002-0536-1329","observed_orcids":["https://orcid.org/0000-0002-0536-1329"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajaneesh Anupam","raw_affiliation_strings":["Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065171760","display_name":"Antara Datta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antara Datta","raw_affiliation_strings":["Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019998970","display_name":"Nadine Bowden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadine Bowden","raw_affiliation_strings":["Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023115667","display_name":"Nikolozi Shkriabai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolozi Shkriabai","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072685090","display_name":"Mamuka Kvaratskhelia","orcid":"https://orcid.org/0000-0003-3800-0033","observed_orcids":["https://orcid.org/0000-0003-3800-0033"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mamuka Kvaratskhelia","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078184468","display_name":"Michael D. Lairmore","orcid":"https://orcid.org/0000-0002-4529-7480","observed_orcids":["https://orcid.org/0000-0002-4529-7480"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Lairmore","raw_affiliation_strings":["Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, 43210, USA","Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, 43210, USA","Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078184468"],"corresponding_institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.1409,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5406794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/p30","display_name":"p30","score":0.8529999852180481},{"id":"https://openalex.org/keywords/reggamma","display_name":"REG\u03b3","score":0.8949999809265137},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.8209999799728394},{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.4970000088214874},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.7269999980926514},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.5950000286102295},{"id":"https://openalex.org/keywords/viral-spread","display_name":"viral spread","score":0.5550000071525574},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.643953800201416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5699244141578674},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5693371295928955},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4382394850254059},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3400675058364868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.277280330657959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2543150782585144},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11279675364494324},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1742-4690-8-s1-a202","doi":"https://doi.org/10.1186/1742-4690-8-s1-a202","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-8-s1-a202","pdf_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/1742-4690-8-S1-A202","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3112679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3112679","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1742-4690-8-s1-a202","doi":"https://doi.org/10.1186/1742-4690-8-s1-a202","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-8-s1-a202","pdf_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/1742-4690-8-S1-A202","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2093613636.pdf","grobid_xml":"https://content.openalex.org/works/W2093613636.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985043729","https://openalex.org/W2597711841","https://openalex.org/W2162790887","https://openalex.org/W2612933850","https://openalex.org/W2007758478","https://openalex.org/W2141990147","https://openalex.org/W2596130312","https://openalex.org/W2531385493","https://openalex.org/W2995165229","https://openalex.org/W2031186253"],"abstract_inverted_index":{"Human":[0],"T":[1],"cell":[2,40,143,226],"leukemia":[3],"virus":[4],"type":[5],"1":[6],"(HTLV-1),":[7],"is":[8,44],"complex":[9,180],"deltaretrovirus":[10],"linked":[11],"to":[12,60,82,101,115,220],"adult":[13],"T-cell":[14],"leukemia/lymphoma":[15],"(ATL)":[16],"and":[17,34,43,58,64,120,141,184,198,218],"a":[18,25,176],"variety":[19],"of":[20,72,84,93,106,129,139,149,158,164,173],"immune-mediated":[21],"disorders.":[22],"HTLV-1":[23,204,213],"encodes":[24],"nuclear":[26,123],"localizing":[27],"protein,":[28],"p30,":[29],"which":[30],"selectively":[31],"alters":[32],"viral":[33,47,65,85,222],"cellular":[35,53,76,80,103,116],"gene":[36,66],"expression,":[37],"activates":[38],"G2-M":[39],"cycle":[41],"checkpoints,":[42],"essential":[45],"for":[46,194],"spread.":[48,86],"p30":[49,73,96,112,132,152,159,174,214],"interacts":[50,215],"with":[51,74,98,136,182,216],"key":[52],"proteins":[54,77],"such":[55],"as":[56],"CBP/p300":[57],"Myc/TIP60":[59],"differentially":[61],"modulate":[62],"host":[63,75],"expression.":[67],"We":[68],"hypothesize":[69],"that":[70,111,212],"interaction":[71,201],"modulates":[78],"the":[79,162,171],"microenvironment":[81],"favor":[83],"Herein":[87],"we":[88,210],"used":[89],"immunoprecipitation,":[90],"affinity":[91],"pull-down":[92],"ectopically":[94],"expressed":[95],"coupled":[97],"mass":[99],"spectrometry":[100],"identify":[102],"binding":[104,197],"partners":[105],"p30.":[107],"Our":[108],"data":[109],"indicate":[110],"specifically":[113],"binds":[114],"ataxia-telangiectasia":[117],"mutated":[118],"(ATM)":[119],"REG\u03b3":[121,150,196,219],"(a":[122],"20S":[124],"proteasome":[125],"activator).":[126],"In":[127],"conditions":[128],"genotoxic":[130],"stress":[131],"expression":[133,148,153,160],"was":[134],"associated":[135],"reduced":[137],"levels":[138],"ATM":[140,183,217],"increased":[142],"survival.":[144,227],"Knockdown":[145],"or":[146],"over":[147],"paralleled":[151],"suggesting":[154],"an":[155],"unexpected":[156],"enhancement":[157],"in":[161,175],"presence":[163,172],"REG\u03b3.":[165,185],"Finally,":[166],"size":[167],"exclusion":[168],"chromatography":[169],"revealed":[170],"high":[177],"molecular":[178],"weight":[179],"along":[181],"Current":[186],"studies":[187],"are":[188],"focused":[189],"on":[190,207],"mapping":[191],"regions":[192],"critical":[193],"p30-":[195],"how":[199],"this":[200],"may":[202],"influence":[203],"transcription.":[205],"Based":[206],"our":[208],"findings":[209],"propose":[211],"increase":[221],"spread":[223],"by":[224],"facilitating":[225]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
