{"id":"https://openalex.org/W20935937","doi":"https://doi.org/10.1038/35055010","title":"Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases","display_name":"Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases","publication_year":2001,"publication_date":"2001-01-04","ids":{"openalex":"https://openalex.org/W20935937","doi":"https://doi.org/10.1038/35055010","mag":"20935937","pmid":"https://pubmed.ncbi.nlm.nih.gov/11175742"},"language":"en","primary_location":{"id":"doi:10.1038/35055010","doi":"https://doi.org/10.1038/35055010","is_oa":false,"landing_page_url":"https://doi.org/10.1038/35055010","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040845783","display_name":"Angela Taddei","orcid":"https://orcid.org/0000-0002-3217-0739","observed_orcids":["https://orcid.org/0000-0002-3217-0739"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Angela Taddei","raw_affiliation_strings":["Institut Curie/Research section, UMR 218 du CNRS, 26 rue d'Ulm, 75248 Paris cedex 05, France","Institut Curie, Research section, UMR 218 du CNRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie/Research section, UMR 218 du CNRS, 26 rue d'Ulm, 75248 Paris cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Institut Curie, Research section, UMR 218 du CNRS, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016789115","display_name":"Christ\u00e8le Maison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christ\u00e8le Maison","raw_affiliation_strings":["Institut Curie/Research section, UMR 218 du CNRS,  26 rue d'Ulm, Paris, cedex 05, 75248, France","Institut Curie, Research section, UMR 218 du CNRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie/Research section, UMR 218 du CNRS,  26 rue d'Ulm, Paris, cedex 05, 75248, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Institut Curie, Research section, UMR 218 du CNRS, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111665879","display_name":"Dani\u00e8le M.J. Roche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dani\u00e8le Roche","raw_affiliation_strings":["Institut Curie/Research section, UMR 218 du CNRS,  26 rue d'Ulm, Paris, cedex 05, 75248, France","Institut Curie, Research section, UMR 218 du CNRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie/Research section, UMR 218 du CNRS,  26 rue d'Ulm, Paris, cedex 05, 75248, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Institut Curie, Research section, UMR 218 du CNRS, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065132057","display_name":"Genevi\u00e8ve Almouzni","orcid":"https://orcid.org/0000-0001-5570-0723","observed_orcids":["https://orcid.org/0000-0001-5570-0723"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Genevi\u00e8ve Almouzni","raw_affiliation_strings":["Institut Curie/Research section, UMR 218 du CNRS,  26 rue d'Ulm, Paris, cedex 05, 75248, France","Institut Curie, Research section, UMR 218 du CNRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie/Research section, UMR 218 du CNRS,  26 rue d'Ulm, Paris, cedex 05, 75248, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]},{"raw_affiliation_string":"Institut Curie, Research section, UMR 218 du CNRS, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065132057"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I80043"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":10.4733,"has_fulltext":false,"cited_by_count":362,"citation_normalized_percentile":{"value":0.99196703,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"3","issue":"2","first_page":"114","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pericentromeric-heterochromatin","display_name":"pericentromeric heterochromatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/centromere-function","display_name":"centromere function","score":0.9900000095367432},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hp1-proteins","display_name":"HP1 proteins","score":0.859000027179718},{"id":"https://openalex.org/keywords/chromosome-segregation-errors","display_name":"chromosome segregation errors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nuclear-compartmentalization","display_name":"nuclear compartmentalization","score":0.703000009059906},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.9182906150817871},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.8200369477272034},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.7294104099273682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6755744218826294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6729459166526794},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.6547114849090576},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6275719404220581},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6221275925636292},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.5962761044502258},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5160910487174988},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.4998741149902344},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.4356307089328766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3863871395587921},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3497830033302307},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.058349043130874634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/35055010","doi":"https://doi.org/10.1038/35055010","is_oa":false,"landing_page_url":"https://doi.org/10.1038/35055010","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},{"id":"pmid:11175742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11175742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321617","display_name":"Minist\u00e8re de l'\u00c9ducation Nationale","ror":"https://ror.org/04xp49e10"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320328582","display_name":"Minist\u00e8re de l'\u00c9ducation et de l'Enseignement sup\u00e9rieur","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W143303542","https://openalex.org/W191579649","https://openalex.org/W1490231232","https://openalex.org/W1521333964","https://openalex.org/W1575224321","https://openalex.org/W1581072348","https://openalex.org/W1652583010","https://openalex.org/W1797040506","https://openalex.org/W1964716733","https://openalex.org/W1969373767","https://openalex.org/W1969472156","https://openalex.org/W1976623855","https://openalex.org/W1988073250","https://openalex.org/W1991085321","https://openalex.org/W1991125055","https://openalex.org/W1993254105","https://openalex.org/W1996978236","https://openalex.org/W1998475589","https://openalex.org/W2001864787","https://openalex.org/W2002698073","https://openalex.org/W2007303315","https://openalex.org/W2022537514","https://openalex.org/W2024310026","https://openalex.org/W2029301727","https://openalex.org/W2041860345","https://openalex.org/W2044827050","https://openalex.org/W2051387354","https://openalex.org/W2054600961","https://openalex.org/W2054696920","https://openalex.org/W2058463078","https://openalex.org/W2068032875","https://openalex.org/W2068301121","https://openalex.org/W2088974911","https://openalex.org/W2093217651","https://openalex.org/W2098141162","https://openalex.org/W2110576677","https://openalex.org/W2131687205","https://openalex.org/W2141452262","https://openalex.org/W2146295682","https://openalex.org/W2183407416","https://openalex.org/W2338626263","https://openalex.org/W4388385144"],"related_works":["https://openalex.org/W2071393652","https://openalex.org/W2098141162","https://openalex.org/W2119143930","https://openalex.org/W2001836880","https://openalex.org/W4297924337","https://openalex.org/W2071949364","https://openalex.org/W2068690942","https://openalex.org/W2170515091","https://openalex.org/W7108611042","https://openalex.org/W2393541386"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}