{"id":"https://openalex.org/W2093550436","doi":"https://doi.org/10.1002/jps.2600591007","title":"Potential Antiarrhythmic Agents II: Effects of Amide Reversal and ortho-Methylation on Activity of Procaine Amide","display_name":"Potential Antiarrhythmic Agents II: Effects of Amide Reversal and ortho-Methylation on Activity of Procaine Amide","publication_year":1970,"publication_date":"1970-10-01","ids":{"openalex":"https://openalex.org/W2093550436","doi":"https://doi.org/10.1002/jps.2600591007","mag":"2093550436","pmid":"https://pubmed.ncbi.nlm.nih.gov/5471943"},"language":"en","primary_location":{"id":"doi:10.1002/jps.2600591007","doi":"https://doi.org/10.1002/jps.2600591007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600591007","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006062645","display_name":"David K. Yung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D.K. Yung","raw_affiliation_strings":["College of Pharmacy, Faculty of Health Professions, and the Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N. S., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Faculty of Health Professions, and the Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N. S., Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065720786","display_name":"Man M. Vohra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M.M. Vohra","raw_affiliation_strings":["College of Pharmacy, Faculty of Health Professions, and the Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N. S., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Faculty of Health Professions, and the Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N. S., Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110005376","display_name":"I. Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"I. Chu","raw_affiliation_strings":["College of Pharmacy, Faculty of Health Professions, and the Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N. S., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Faculty of Health Professions, and the Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N. S., Canada","institution_ids":["https://openalex.org/I129902397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129902397"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":1.626,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.84120692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"10","first_page":"1405","last_page":"1409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ouabain-induced-arrhythmia","display_name":"ouabain-induced arrhythmia","score":0.7720000147819519},{"id":"https://openalex.org/keywords/aconitine-induced-arrhythmia","display_name":"aconitine-induced arrhythmia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/atrial-refractory-period","display_name":"atrial refractory period","score":0.8339999914169312},{"id":"https://openalex.org/keywords/local-anesthetic-activity","display_name":"local anesthetic activity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/corneal-reflex","display_name":"corneal reflex","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.656000018119812},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.7801430821418762},{"id":"https://openalex.org/C2779828710","wikidata":"https://www.wikidata.org/wiki/Q423741","display_name":"Procaine","level":2,"score":0.7775799036026001},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7665793895721436},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.6423671841621399},{"id":"https://openalex.org/C2777028498","wikidata":"https://www.wikidata.org/wiki/Q417597","display_name":"Procainamide","level":2,"score":0.6417543888092041},{"id":"https://openalex.org/C2777547430","wikidata":"https://www.wikidata.org/wiki/Q342108","display_name":"Aconitine","level":2,"score":0.5927013754844666},{"id":"https://openalex.org/C2780339425","wikidata":"https://www.wikidata.org/wiki/Q412496","display_name":"Quinidine","level":2,"score":0.5344551801681519},{"id":"https://openalex.org/C189327125","wikidata":"https://www.wikidata.org/wiki/Q5347276","display_name":"Effective refractory period","level":3,"score":0.5226387977600098},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3850090205669403},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3480883240699768},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2962355613708496},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.29495733976364136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21364960074424744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19052287936210632},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12817591428756714},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10866779088973999},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011342","descriptor_name":"Procainamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011342","descriptor_name":"Procainamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031841","descriptor_name":"Aconitum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.2600591007","doi":"https://doi.org/10.1002/jps.2600591007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600591007","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:5471943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5471943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1970639406","https://openalex.org/W1972263841","https://openalex.org/W2000565952","https://openalex.org/W2048490097","https://openalex.org/W2087203409","https://openalex.org/W2092899357","https://openalex.org/W2126321508","https://openalex.org/W2240888534","https://openalex.org/W2242429487","https://openalex.org/W2316637858","https://openalex.org/W2401188729"],"related_works":["https://openalex.org/W2076842302","https://openalex.org/W1972263841","https://openalex.org/W2071732292","https://openalex.org/W2076508229","https://openalex.org/W2951911965","https://openalex.org/W2084979592","https://openalex.org/W2145292078","https://openalex.org/W3021253017","https://openalex.org/W2069278389","https://openalex.org/W1897540448"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}