{"id":"https://openalex.org/W2093535002","doi":"https://doi.org/10.15430/jcp.2014.19.2.75","title":"Endoplasmic Reticulum Stress and Cancer","display_name":"Endoplasmic Reticulum Stress and Cancer","publication_year":2014,"publication_date":"2014-06-30","ids":{"openalex":"https://openalex.org/W2093535002","doi":"https://doi.org/10.15430/jcp.2014.19.2.75","mag":"2093535002","pmid":"https://pubmed.ncbi.nlm.nih.gov/25337575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4204165"},"language":"en","primary_location":{"id":"doi:10.15430/jcp.2014.19.2.75","doi":"https://doi.org/10.15430/jcp.2014.19.2.75","is_oa":false,"landing_page_url":"https://doi.org/10.15430/jcp.2014.19.2.75","pdf_url":null,"source":{"id":"https://openalex.org/S2765040313","display_name":"Journal of Cancer Prevention","issn_l":"2288-3649","issn":["2288-3649","2288-3657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","ki-jl-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4204165","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Raj Kumar Yadav","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Raj Kumar Yadav","raw_affiliation_strings":["Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050666299","display_name":"Soo\u2010Wan Chae","orcid":"https://orcid.org/0000-0003-3660-8272","observed_orcids":["https://orcid.org/0000-0003-3660-8272"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Wan Chae","raw_affiliation_strings":["Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041473993","display_name":"Hyung\u2010Ryong Kim","orcid":"https://orcid.org/0000-0002-6710-6964","observed_orcids":["https://orcid.org/0000-0002-6710-6964","https://orcid.org/0000-0003-0225-9684"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Ryong Kim","raw_affiliation_strings":["Department of Dental Pharmacology, College of Dentistry, Wonkwang University, Iksan, Chonbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Pharmacology, College of Dentistry, Wonkwang University, Iksan, Chonbuk, Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077043027","display_name":"Han\u2013Jung Chae","orcid":"https://orcid.org/0000-0003-4190-9889","observed_orcids":["https://orcid.org/0000-0003-4190-9889"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Han Jung Chae","raw_affiliation_strings":["Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea","institution_ids":["https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077043027"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":null,"apc_paid":null,"fwci":2.0964,"has_fulltext":false,"cited_by_count":402,"citation_normalized_percentile":{"value":0.89731544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"19","issue":"2","first_page":"75","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":1.0},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cancer-treatment-resistance","display_name":"cancer therapy resistance","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6710000038146973},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.9308803677558899},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.906653642654419},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5928111672401428},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5372417569160461},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5148874521255493},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4994497299194336},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4957784116268158},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.4637293219566345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3861181139945984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3838307559490204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.061597228050231934}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.15430/jcp.2014.19.2.75","doi":"https://doi.org/10.15430/jcp.2014.19.2.75","is_oa":false,"landing_page_url":"https://doi.org/10.15430/jcp.2014.19.2.75","pdf_url":null,"source":{"id":"https://openalex.org/S2765040313","display_name":"Journal of Cancer Prevention","issn_l":"2288-3649","issn":["2288-3649","2288-3657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","ki-jl-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4204165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4204165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Prev","raw_type":"Text"},{"id":"pmid:25337575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25337575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer prevention","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4204165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4204165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Prev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":161,"referenced_works":["https://openalex.org/W996395697","https://openalex.org/W1527321800","https://openalex.org/W1537539007","https://openalex.org/W1592978302","https://openalex.org/W1743523754","https://openalex.org/W1942176190","https://openalex.org/W1966238197","https://openalex.org/W1967329857","https://openalex.org/W1967333299","https://openalex.org/W1968486675","https://openalex.org/W1969916031","https://openalex.org/W1970305423","https://openalex.org/W1974191631","https://openalex.org/W1974515735","https://openalex.org/W1976161806","https://openalex.org/W1976632546","https://openalex.org/W1979592430","https://openalex.org/W1980438612","https://openalex.org/W1981515291","https://openalex.org/W1981589849","https://openalex.org/W1985896963","https://openalex.org/W1985970875","https://openalex.org/W1986698508","https://openalex.org/W1987331911","https://openalex.org/W1991250346","https://openalex.org/W1991631628","https://openalex.org/W1991999080","https://openalex.org/W1993401552","https://openalex.org/W1993953120","https://openalex.org/W1994138076","https://openalex.org/W1995786747","https://openalex.org/W1996213381","https://openalex.org/W1996951402","https://openalex.org/W1998626286","https://openalex.org/W2001399725","https://openalex.org/W2002439304","https://openalex.org/W2003977015","https://openalex.org/W2007078899","https://openalex.org/W2008683065","https://openalex.org/W2010645035","https://openalex.org/W2012166934","https://openalex.org/W2015095309","https://openalex.org/W2016000163","https://openalex.org/W2017516497","https://openalex.org/W2018504915","https://openalex.org/W2019493843","https://openalex.org/W2021425674","https://openalex.org/W2021617109","https://openalex.org/W2021627297","https://openalex.org/W2025997346","https://openalex.org/W2027253807","https://openalex.org/W2030230298","https://openalex.org/W2030739080","https://openalex.org/W2032379590","https://openalex.org/W2032584297","https://openalex.org/W2033323077","https://openalex.org/W2034213169","https://openalex.org/W2036235250","https://openalex.org/W2038018821","https://openalex.org/W2041581075","https://openalex.org/W2043297474","https://openalex.org/W2046949873","https://openalex.org/W2049512057","https://openalex.org/W2051146343","https://openalex.org/W2052464502","https://openalex.org/W2053442171","https://openalex.org/W2056984964","https://openalex.org/W2057279293","https://openalex.org/W2058785552","https://openalex.org/W2062145087","https://openalex.org/W2062519528","https://openalex.org/W2063066838","https://openalex.org/W2066606787","https://openalex.org/W2068221097","https://openalex.org/W2068464911","https://openalex.org/W2071974979","https://openalex.org/W2072185042","https://openalex.org/W2072714194","https://openalex.org/W2074471441","https://openalex.org/W2074802590","https://openalex.org/W2075115412","https://openalex.org/W2075616952","https://openalex.org/W2076373319","https://openalex.org/W2076395806","https://openalex.org/W2079791855","https://openalex.org/W2080901528","https://openalex.org/W2082523839","https://openalex.org/W2084276537","https://openalex.org/W2084944302","https://openalex.org/W2085201901","https://openalex.org/W2085966620","https://openalex.org/W2089032508","https://openalex.org/W2092487631","https://openalex.org/W2092537575","https://openalex.org/W2093158584","https://openalex.org/W2093763122","https://openalex.org/W2099756248","https://openalex.org/W2100206117","https://openalex.org/W2100347985","https://openalex.org/W2100948166","https://openalex.org/W2102025854","https://openalex.org/W2105542363","https://openalex.org/W2106163662","https://openalex.org/W2106188607","https://openalex.org/W2106958893","https://openalex.org/W2108235071","https://openalex.org/W2110212786","https://openalex.org/W2110524342","https://openalex.org/W2110966542","https://openalex.org/W2113915760","https://openalex.org/W2114360920","https://openalex.org/W2115205812","https://openalex.org/W2116090592","https://openalex.org/W2117140009","https://openalex.org/W2120736516","https://openalex.org/W2121173674","https://openalex.org/W2122611359","https://openalex.org/W2122684363","https://openalex.org/W2123501897","https://openalex.org/W2126530235","https://openalex.org/W2127453231","https://openalex.org/W2127848114","https://openalex.org/W2128327076","https://openalex.org/W2129058679","https://openalex.org/W2129163103","https://openalex.org/W2129515878","https://openalex.org/W2129695436","https://openalex.org/W2132702191","https://openalex.org/W2133540186","https://openalex.org/W2133644385","https://openalex.org/W2134197723","https://openalex.org/W2134573355","https://openalex.org/W2135131077","https://openalex.org/W2135881812","https://openalex.org/W2137755719","https://openalex.org/W2138077682","https://openalex.org/W2139112064","https://openalex.org/W2139568257","https://openalex.org/W2140811961","https://openalex.org/W2142282255","https://openalex.org/W2143224622","https://openalex.org/W2144428144","https://openalex.org/W2144670533","https://openalex.org/W2148172443","https://openalex.org/W2149843709","https://openalex.org/W2151878529","https://openalex.org/W2152163817","https://openalex.org/W2153987976","https://openalex.org/W2155163967","https://openalex.org/W2155945227","https://openalex.org/W2157371003","https://openalex.org/W2158837517","https://openalex.org/W2160380481","https://openalex.org/W2163285372","https://openalex.org/W2165048368","https://openalex.org/W2165623186","https://openalex.org/W2169879031","https://openalex.org/W2172182710","https://openalex.org/W2329529383","https://openalex.org/W2415186660","https://openalex.org/W2417191926"],"related_works":["https://openalex.org/W1204700888","https://openalex.org/W2776594550","https://openalex.org/W2080780641","https://openalex.org/W2341141208","https://openalex.org/W4411465775","https://openalex.org/W7164847732","https://openalex.org/W2007954304","https://openalex.org/W2608026191","https://openalex.org/W2759606873","https://openalex.org/W4414913722"],"abstract_inverted_index":{"The":[0,65],"endoplasmic":[1],"reticulum":[2],"(ER)":[3],"is":[4,26,78],"the":[5,19,35,51,60,63,70,89],"principal":[6],"organelle":[7],"responsible":[8],"for":[9],"multiple":[10],"cellular":[11,22],"functions":[12],"including":[13],"protein":[14,37],"folding":[15],"and":[16,18,33,56,58,97],"maturation":[17],"maintenance":[20],"of":[21,31,62,73,80,91],"homeostasis.":[23],"ER":[24,54],"stress":[25,55],"activated":[27],"by":[28],"a":[29],"variety":[30],"factors":[32],"triggers":[34],"unfolded":[36],"response":[38],"(UPR),":[39],"which":[40],"restores":[41],"homeostasis":[42],"or":[43],"activates":[44],"cell":[45],"death.":[46],"Multiple":[47],"studies":[48],"have":[49],"clarified":[50],"link":[52],"between":[53],"cancer,":[57],"particularly":[59],"involvement":[61],"UPR.":[64],"UPR":[66],"seems":[67],"to":[68,99],"adjust":[69],"paradoxical":[71],"microenvironment":[72],"cancer":[74,84,100],"and,":[75],"as":[76],"such,":[77],"one":[79],"resistance":[81,98],"mechanisms":[82],"against":[83],"therapy.":[85,101],"This":[86],"review":[87],"describes":[88],"activity":[90],"different":[92],"UPRs":[93],"involved":[94],"in":[95],"tumorigenesis":[96]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":42},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":44},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}