{"id":"https://openalex.org/W2093508259","doi":"https://doi.org/10.1161/01.str.19.2.251","title":"Regional creatine kinase, adenylate kinase, and lactate dehydrogenase in normal canine brain.","display_name":"Regional creatine kinase, adenylate kinase, and lactate dehydrogenase in normal canine brain.","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W2093508259","doi":"https://doi.org/10.1161/01.str.19.2.251","mag":"2093508259","pmid":"https://pubmed.ncbi.nlm.nih.gov/2830684"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.19.2.251","doi":"https://doi.org/10.1161/01.str.19.2.251","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.19.2.251","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077995419","display_name":"Wayne Leslie Chandler","orcid":"https://orcid.org/0000-0002-0431-7633","observed_orcids":["https://orcid.org/0000-0002-0431-7633"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W L Chandler","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109270246","display_name":"James S. Fine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Fine","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110183213","display_name":"Michael J. Emery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Emery","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Weaver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Weaver","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023903344","display_name":"Dennis D. Reichenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Reichenbach","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083087525","display_name":"Kathleen J. Clayson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K J Clayson","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":0.7625,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73009036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"19","issue":"2","first_page":"251","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.09520000219345093,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/creatine-kinase-isozymes","display_name":"creatine kinase isoenzymes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/adenylate-kinase","display_name":"adenylate kinase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/canine-brain","display_name":"canine brain","score":0.7839999794960022},{"id":"https://openalex.org/keywords/gray-and-white-matter","display_name":"gray and white matter","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitochondrial-creatine-kinase","display_name":"mitochondrial creatine kinase","score":0.906000018119812},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.8553357720375061},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.8301325440406799},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.6540803909301758},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5563991069793701},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.5208380818367004},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46544349193573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4532235562801361},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4520520865917206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34547221660614014},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30114102363586426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2937019467353821},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000263","descriptor_name":"Adenylate Kinase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.str.19.2.251","doi":"https://doi.org/10.1161/01.str.19.2.251","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.19.2.251","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:2830684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2830684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"mag:3147889214","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/str.19.2.2830684?related-urls=yes&legid=strokeaha%3B19%2F2%2F251&legid=strokeaha%3B19%2F2%2F251&cited-by=yes","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Stroke","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1825895411","https://openalex.org/W1894751544","https://openalex.org/W1948308962","https://openalex.org/W1974896400","https://openalex.org/W1975258682","https://openalex.org/W1976045851","https://openalex.org/W1982996451","https://openalex.org/W1990939027","https://openalex.org/W2012792017","https://openalex.org/W2019222057","https://openalex.org/W2039622754","https://openalex.org/W2041979466","https://openalex.org/W2053171308","https://openalex.org/W2093949644","https://openalex.org/W2138356837","https://openalex.org/W2158552603","https://openalex.org/W2160073161","https://openalex.org/W2257595422","https://openalex.org/W2315440318","https://openalex.org/W2319385093"],"related_works":["https://openalex.org/W253680315","https://openalex.org/W2006250964","https://openalex.org/W2052144936","https://openalex.org/W2158552603","https://openalex.org/W2064576173","https://openalex.org/W1825895411","https://openalex.org/W2079638207","https://openalex.org/W2023693197","https://openalex.org/W2036117145","https://openalex.org/W1552680467"],"abstract_inverted_index":{"Following":[0],"acute":[1],"stroke,":[2],"creatine":[3,44,113,119,151,176,198],"kinase":[4,62,87,114,120,152,177,199],"and":[5,14,31,48,88,104,117,206],"other":[6],"enzymes":[7],"are":[8],"released":[9],"into":[10],"the":[11,34,41,65,160,167,173,195],"cerebrospinal":[12,204],"fluid":[13,205],"blood":[15],"from":[16,156],"injured":[17],"brain":[18,26,57,115,123,153,178,200],"tissue.":[19],"To":[20],"determine":[21],"whether":[22],"regional":[23,148,189],"differences":[24],"in":[25,51,94,101,107,121,150,159,166,194,203],"enzyme":[27,37],"activity":[28,63,77,93,100,106],"might":[29],"exist":[30],"therefore":[32],"affect":[33],"amount":[35],"of":[36,43,54,112,175,186,197],"released,":[38],"we":[39],"quantified":[40],"levels":[42],"kinase,":[45,47],"adenylate":[46,86],"lactate":[49,75,89],"dehydrogenase":[50,76,90],"12":[52],"regions":[53,68,131],"normal":[55],"canine":[56,122],"(n":[58],"=":[59],"4).":[60],"Adenylate":[61],"varied":[64],"least":[66],"among":[67,130,184],"(49":[69],"+/-":[70,79,134,139],"7":[71],"units/g),":[72],"followed":[73],"by":[74],"(122":[78],"28":[80],"units/g).":[81,141],"The":[82,110],"pattern":[83],"for":[84],"both":[85],"was":[91,124],"higher":[92],"predominantly":[95],"gray":[96,144],"matter":[97,145],"areas,":[98],"lower":[99],"white":[102],"matter,":[103],"intermediate":[105],"mixed":[108],"regions.":[109],"distribution":[111],"isoenzyme":[116,179,201],"mitochondrial":[118],"less":[125],"predictable,":[126],"showing":[127],"wider":[128],"variations":[129,149],"(isoenzyme,":[132],"462":[133],"116":[135],"units/g;":[136],"mitochondrial,":[137],"42":[138],"20":[140],"Even":[142],"cerebral":[143],"demonstrated":[146],"substantial":[147],"isoenzyme,":[154],"ranging":[155],"606":[157],"units/g":[158,165],"parietal":[161],"cortex":[162],"to":[163,209],"329":[164],"temporal":[168],"cortex.":[169],"We":[170],"conclude":[171],"that":[172],"content":[174],"varies":[180],"more":[181],"than":[182],"twofold":[183],"areas":[185],"brain.":[187],"This":[188],"variation":[190],"may":[191],"be":[192],"important":[193],"interpretation":[196],"measurements":[202],"serum":[207],"used":[208],"assess":[210],"neurologic":[211],"injury":[212],"following":[213],"stroke.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
