{"id":"https://openalex.org/W2093418092","doi":"https://doi.org/10.1253/jcj.60.673","title":"Mitochondrial Respiratory Impairment in Streptozotocin-Induced Diabetic Rat Heart","display_name":"Mitochondrial Respiratory Impairment in Streptozotocin-Induced Diabetic Rat Heart","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2093418092","doi":"https://doi.org/10.1253/jcj.60.673","mag":"2093418092","pmid":"https://pubmed.ncbi.nlm.nih.gov/8902585"},"language":"en","primary_location":{"id":"doi:10.1253/jcj.60.673","doi":"https://doi.org/10.1253/jcj.60.673","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.60.673","pdf_url":"https://www.jstage.jst.go.jp/article/jcj/60/9/60_9_673/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jcj/60/9/60_9_673/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111869284","display_name":"Masataka Tomita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Tomita","raw_affiliation_strings":["The Third Department of Internal Medicine, Showa University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Showa University, School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109529773","display_name":"Syuji Mukae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Syuji Mukae","raw_affiliation_strings":["The Third Department of Internal Medicine, Showa University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Showa University, School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048340159","display_name":"Eiichi Geshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiichi Geshi","raw_affiliation_strings":["The Third Department of Internal Medicine, Showa University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Showa University, School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112171373","display_name":"Kazuhiko Umetsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Umetsu","raw_affiliation_strings":["The Third Department of Internal Medicine, Showa University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Showa University, School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011167098","display_name":"Masaki Nakatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Nakatani","raw_affiliation_strings":["The Third Department of Internal Medicine, Showa University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Showa University, School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101051267","display_name":"Takashi Katagiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Katagiri","raw_affiliation_strings":["The Third Department of Internal Medicine, Showa University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Showa University, School of Medicine","institution_ids":["https://openalex.org/I119182057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I119182057"],"apc_list":null,"apc_paid":null,"fwci":0.1061,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.32659901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"60","issue":"9","first_page":"673","last_page":"682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain","display_name":"mitochondrial respiratory chain","score":0.6370000243186951},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/complex-i","display_name":"complex I","score":0.8899999856948853},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.7409999966621399},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9139999747276306},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.7300000190734863},{"id":"https://openalex.org/keywords/diabetic-heart","display_name":"diabetic heart","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8654752373695374},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.8022599220275879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7507150173187256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6829143166542053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6510648131370544},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.631837010383606},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5418153405189514},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.509112536907196},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4598762094974518},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.429127037525177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18099841475486755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05912819504737854}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008933","descriptor_name":"Mitochondrial Swelling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1253/jcj.60.673","doi":"https://doi.org/10.1253/jcj.60.673","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.60.673","pdf_url":"https://www.jstage.jst.go.jp/article/jcj/60/9/60_9_673/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},{"id":"pmid:8902585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8902585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese circulation journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1253/jcj.60.673","doi":"https://doi.org/10.1253/jcj.60.673","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.60.673","pdf_url":"https://www.jstage.jst.go.jp/article/jcj/60/9/60_9_673/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2093418092.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W21147276","https://openalex.org/W58529996","https://openalex.org/W102996746","https://openalex.org/W155146360","https://openalex.org/W1266496976","https://openalex.org/W1575852352","https://openalex.org/W1749048561","https://openalex.org/W1819875704","https://openalex.org/W2002055678","https://openalex.org/W2003030446","https://openalex.org/W2021172172","https://openalex.org/W2035887756","https://openalex.org/W2041847146","https://openalex.org/W2056199973","https://openalex.org/W2059357264","https://openalex.org/W2059537042","https://openalex.org/W2070692648","https://openalex.org/W2081864945","https://openalex.org/W2082904400","https://openalex.org/W2085087376","https://openalex.org/W2096242493","https://openalex.org/W2105094693","https://openalex.org/W2111716072","https://openalex.org/W2127321192","https://openalex.org/W2141742918","https://openalex.org/W2153435210","https://openalex.org/W2161072838","https://openalex.org/W2182387002","https://openalex.org/W2473971603","https://openalex.org/W4244709313"],"related_works":["https://openalex.org/W2293970235","https://openalex.org/W58529996","https://openalex.org/W2523538607","https://openalex.org/W2284577338","https://openalex.org/W7096210269","https://openalex.org/W2076200760","https://openalex.org/W2005870745","https://openalex.org/W3207333008","https://openalex.org/W7099935324","https://openalex.org/W2064015939"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,26,38,90,109,131,159,170,176,193],"this":[3],"study":[4],"was":[5,17,43,58,70,87],"to":[6,31,51,61,72,105,174],"examine":[7],"mitochondrial":[8],"respiratory":[9],"impairment":[10,169],"in":[11,19,66,76,92,111,137,140,154,162],"the":[12,39,93,112,132,155,168,186],"diabetic":[13,40,141,156],"heart.":[14],"Diabetes":[15],"mellitus":[16],"induced":[18],"male":[20],"Wistar":[21],"rats":[22],"by":[23,167],"intravenous":[24],"injection":[25],"streptozotocin":[27],"(STZ)":[28],"for":[29,45,124],"2":[30,46,80],"16":[32,125],"weeks":[33,49,81],"(Group":[34,53],"D).":[35],"In":[36],"some":[37],"rats,":[41],"insulin":[42,119,149],"injected":[44],"or":[47],"3":[48,86],"prior":[50],"sacrifice":[52],"I).":[54],"Fasting":[55],"blood":[56],"glucose":[57,74],"markedly":[59],"elevated":[60],"greater":[62],"than":[63],"300":[64],"mg/dl":[65],"Group":[67,77],"D":[68],"and":[69,97,107,134,143,179],"similar":[71],"normal":[73],"levels":[75],"I.":[78],"At":[79],"after":[82],"STZ":[83],"injection,":[84],"state":[85],"only":[88],"59.1%":[89],"that":[91,153,189],"control.":[94],"Complex":[95],"I":[96,178],"complex":[98,177,180],"V":[99],"activities":[100],"were":[101,145],"also":[102,146],"significantly":[103],"reduced":[104],"43.4%":[106],"71.7%":[108],"those":[110],"control,":[113],"respectively.":[114],"These":[115,182],"reductions":[116],"recovered":[117],"with":[118,148],"treatment.":[120,150],"This":[121],"phenomenon":[122],"persisted":[123],"weeks.":[126],"Morphological":[127],"studies":[128],"revealed":[129],"swelling":[130],"mitochondria":[133,164],"an":[135],"increase":[136],"lipid":[138],"droplets":[139],"cardiomyocytes,":[142],"these":[144],"improved":[147],"We":[151],"conclude":[152],"heart,":[157],"disturbance":[158],"energy":[160],"production":[161],"cardiac":[163,187],"is":[165,190],"generated":[166],"oxidative":[171],"phosphorylation":[172],"due":[173],"depression":[175],"V.":[181],"changes":[183],"may":[184],"contribute":[185],"dysfunction":[188],"a":[191],"complication":[192],"diabetes":[194],"mellitus.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}