{"id":"https://openalex.org/W2093344705","doi":"https://doi.org/10.3109/00016487309139694","title":"The Effects Of Ethacrynic Acid Upon The Cochlear Endolymph And Stria Vascularis:A Preliminary Report","display_name":"The Effects Of Ethacrynic Acid Upon The Cochlear Endolymph And Stria Vascularis:A Preliminary Report","publication_year":1973,"publication_date":"1973-01-01","ids":{"openalex":"https://openalex.org/W2093344705","doi":"https://doi.org/10.3109/00016487309139694","mag":"2093344705","pmid":"https://pubmed.ncbi.nlm.nih.gov/4692100"},"language":"en","primary_location":{"id":"doi:10.3109/00016487309139694","doi":"https://doi.org/10.3109/00016487309139694","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016487309139694","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074576187","display_name":"S. K. Bosher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. K. Bosher","raw_affiliation_strings":["Ferens Institute of Otolaryngology, Middlesex Hospital Medical School, University of London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferens Institute of Otolaryngology, Middlesex Hospital Medical School, University of London, London, England","institution_ids":["https://openalex.org/I124357947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101443397","display_name":"Catherine A. Smith","orcid":"https://orcid.org/0000-0002-2943-8175","observed_orcids":["https://orcid.org/0000-0002-2943-8175"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Smith","raw_affiliation_strings":["Ferens Institute of Otolaryngology, Middlesex Hospital Medical School, University of London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferens Institute of Otolaryngology, Middlesex Hospital Medical School, University of London, London, England","institution_ids":["https://openalex.org/I124357947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069256249","display_name":"Rebecca Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. L. Warren","raw_affiliation_strings":["Ferens Institute of Otolaryngology, Middlesex Hospital Medical School, University of London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ferens Institute of Otolaryngology, Middlesex Hospital Medical School, University of London, London, England","institution_ids":["https://openalex.org/I124357947"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I124357947"],"apc_list":null,"apc_paid":null,"fwci":5.4895,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.96933187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"75","issue":"2-6","first_page":"184","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethacrynic-acid","display_name":"ethacrynic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endocochlear-potential","display_name":"endocochlear potential","score":0.9139999747276306},{"id":"https://openalex.org/keywords/endolymph","display_name":"endolymph","score":0.7289999723434448},{"id":"https://openalex.org/keywords/stria-vascularis","display_name":"stria vascularis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cochlea","display_name":"cochlea","score":0.5720000267028809},{"id":"https://openalex.org/keywords/potassium-diffusion-potential","display_name":"potassium diffusion potential","score":0.6060000061988831},{"id":"https://openalex.org/keywords/sodium-and-potassium-concentrations","display_name":"sodium and potassium concentrations","score":0.5899999737739563},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2780921233","wikidata":"https://www.wikidata.org/wiki/Q5376300","display_name":"Endocochlear potential","level":3,"score":0.9622722864151001},{"id":"https://openalex.org/C2778969067","wikidata":"https://www.wikidata.org/wiki/Q1340752","display_name":"Endolymph","level":3,"score":0.7170722484588623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.682440459728241},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.5958283543586731},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5421718955039978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42180579900741577},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.41461294889450073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41101253032684326},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.32176733016967773},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2845138907432556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16368070244789124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16105705499649048},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004976","descriptor_name":"Ethacrynic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007761","descriptor_name":"Labyrinthine Fluids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007761","descriptor_name":"Labyrinthine Fluids","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00016487309139694","doi":"https://doi.org/10.3109/00016487309139694","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016487309139694","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},{"id":"pmid:4692100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4692100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-laryngologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1970301046","https://openalex.org/W1972395909","https://openalex.org/W1977738418","https://openalex.org/W1988637004","https://openalex.org/W2003079326","https://openalex.org/W2037020588","https://openalex.org/W2068335453","https://openalex.org/W2079835048","https://openalex.org/W2115772648","https://openalex.org/W2152033505","https://openalex.org/W2317271522","https://openalex.org/W2617337335"],"related_works":["https://openalex.org/W2037918752","https://openalex.org/W2130886376","https://openalex.org/W2313338344","https://openalex.org/W2463770486","https://openalex.org/W2036035406","https://openalex.org/W2018711578","https://openalex.org/W2033363474","https://openalex.org/W2064506089","https://openalex.org/W1998697624","https://openalex.org/W2068335453"],"abstract_inverted_index":{"The":[0,84],"normal":[1],"endocochlear":[2,115],"potential":[3,11,116,123],"was":[4,94],"rapidly":[5],"replaced":[6],"by":[7,61],"a":[8,62,120,125],"negative":[9,126],"anoxic-type":[10],"after":[12],"ethacrynic":[13],"acid":[14],"administration":[15],"(60":[16],"mg/kg)":[17],"in":[18,47,52,81,90],"the":[19,35,48,53,68,75,91,107,111,114],"rat.":[20],"Recovery":[21],"at":[22,31,58],"first":[23],"proceeded":[24],"quickly":[25],"but":[26],"became":[27],"very":[28],"much":[29],"slower":[30],"30":[32],"min.":[33],"However,":[34],"endolym-phatic":[36],"chemical":[37],"composition":[38],"remained":[39],"unaltered":[40],"until":[41],"35":[42],"min,":[43],"when":[44],"progressive":[45],"increase":[46],"sodium":[49],"and":[50,78,97,124],"decrease":[51],"potassium":[54,127],"concentrations":[55],"occurred,":[56],"followed":[57],"1":[59],"hour":[60],"gradual":[63],"return":[64],"towards":[65],"normal.":[66],"Thus":[67],"drug":[69],"probably":[70],"causes":[71],"transient":[72],"inhibition":[73],"of":[74,87],"strial":[76],"enzymes":[77],"then":[79],"abnormalities":[80],"membrane":[82],"permeability.":[83],"characteristic":[85],"accumulation":[86],"inter-cellular":[88],"fluid":[89],"stria":[92],"vascularis":[93],"associated":[95],"with":[96],"seemed":[98],"to":[99],"arise":[100],"from":[101],"these":[102],"permeability":[103],"changes.":[104],"In":[105],"addition,":[106],"findings":[108],"strongly":[109],"support":[110],"concept":[112],"that":[113],"has":[117],"two":[118],"components,":[119],"positive":[121],"secretion":[122],"diffusion":[128],"potential.":[129]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
