{"id":"https://openalex.org/W2093319342","doi":"https://doi.org/10.1002/art.1780260502","title":"Low\u2010Dose D\u2010Penicillamine Therapy in Rheumatoid Arthritis","display_name":"Low\u2010Dose D\u2010Penicillamine Therapy in Rheumatoid Arthritis","publication_year":1983,"publication_date":"1983-05-01","ids":{"openalex":"https://openalex.org/W2093319342","doi":"https://doi.org/10.1002/art.1780260502","mag":"2093319342","pmid":"https://pubmed.ncbi.nlm.nih.gov/6342625"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780260502","doi":"https://doi.org/10.1002/art.1780260502","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780260502","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113740056","display_name":"H. James Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. James Williams","raw_affiliation_strings":["Department of Family and Community Medicine, University of Utah School of Medicine","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Community Medicine, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080344590","display_name":"John R Ward","orcid":"https://orcid.org/0009-0008-4969-023X","observed_orcids":["https://orcid.org/0009-0008-4969-023X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Ward","raw_affiliation_strings":["Department of Family and Community Medicine, University of Utah School of Medicine","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Community Medicine, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104058503","display_name":"James C. Reading","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Reading","raw_affiliation_strings":["Department of Family and Community Medicine, University of Utah School of Medicine","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Community Medicine, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032101750","display_name":"Marlene J. Egger","orcid":"https://orcid.org/0000-0001-8886-7837","observed_orcids":["https://orcid.org/0000-0001-8886-7837"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marlene J. Egger","raw_affiliation_strings":["Department of Family and Community Medicine, University of Utah School of Medicine","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Community Medicine, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078186174","display_name":"John T. Grandone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Grandone","raw_affiliation_strings":["Division of Immunology and Rheumatology, School of Medicine, University of Missouri-Columbia","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, School of Medicine, University of Missouri-Columbia","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072646111","display_name":"Cecil O. Samuelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecil O. Samuelson","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Utah School of Medicine","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059206584","display_name":"Daniel E. Furst","orcid":"https://orcid.org/0000-0001-7857-2373","observed_orcids":["https://orcid.org/0000-0001-7857-2373","https://orcid.org/0000-0002-4018-7629"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Furst","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of California, Los Angeles","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110800374","display_name":"James M. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Sullivan","raw_affiliation_strings":["Arthritis Research Unit, University of Michigan, Ann Arbor","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Research Unit, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013138288","display_name":"Margaret A. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Watson","raw_affiliation_strings":["Division of Arthritis, Harborview Medical Center, Seattle, WA","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Arthritis, Harborview Medical Center, Seattle, WA","institution_ids":["https://openalex.org/I2802336062"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039198965","display_name":"Maria Guttadauria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Guttadauria","raw_affiliation_strings":["Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110270997","display_name":"Edgar S. Cathcart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edgar S. Cathcart","raw_affiliation_strings":["Arthritis Section, Boston University Medical Center","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Section, Boston University Medical Center","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082055827","display_name":"Stanley B. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley B. Kaplan","raw_affiliation_strings":["Department of Medicine, University of Tennessee, Memphis","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Tennessee, Memphis","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111626674","display_name":"James T. Halla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Halla","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Alabama, Birmingham","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Alabama, Birmingham","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084356090","display_name":"Arthur Weinstein","orcid":"https://orcid.org/0000-0002-7248-6623","observed_orcids":["https://orcid.org/0000-0002-7248-6623"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Weinstein","raw_affiliation_strings":["Division of Rheumatic Diseases, Department of Medicine, University of Connecticut, Farmington","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic Diseases, Department of Medicine, University of Connecticut, Farmington","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056507445","display_name":"Paul H. Pl\u00f6tz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul H. Plotz","raw_affiliation_strings":["National Institutes of Arthritis, Metabolism and Digestive Diseases, Bethesda, MD","University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Arthritis, Metabolism and Digestive Diseases, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5113740056"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":9.9225,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.98625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"26","issue":"5","first_page":"581","last_page":"592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillamine","display_name":"D-penicillamine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/low-dose-therapy","display_name":"low-dose therapy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.7250000238418579},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.656000018119812},{"id":"https://openalex.org/keywords/morning-stiffness","display_name":"morning stiffness","score":0.9399999976158142},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2779348387","wikidata":"https://www.wikidata.org/wiki/Q421239","display_name":"Penicillamine","level":2,"score":0.9421725869178772},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8860390186309814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8654555082321167},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6784093379974365},{"id":"https://openalex.org/C2909196033","wikidata":"https://www.wikidata.org/wiki/Q559210","display_name":"Morning stiffness","level":4,"score":0.6382858753204346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5083388686180115},{"id":"https://openalex.org/C2777433710","wikidata":"https://www.wikidata.org/wiki/Q5609571","display_name":"Grip strength","level":2,"score":0.5079846978187561},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.4906519949436188},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42278528213500977},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36683690547943115},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010043","descriptor_name":"Outcome and Process Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780260502","doi":"https://doi.org/10.1002/art.1780260502","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780260502","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:6342625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6342625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332932","display_name":"Merck Sharp and Dohme","ror":"https://ror.org/004nn4n27"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W86126045","https://openalex.org/W1964213995","https://openalex.org/W1969655780","https://openalex.org/W1970579042","https://openalex.org/W1975540168","https://openalex.org/W1981207374","https://openalex.org/W1988048157","https://openalex.org/W2003598299","https://openalex.org/W2015406491","https://openalex.org/W2015408634","https://openalex.org/W2018967405","https://openalex.org/W2021527593","https://openalex.org/W2026300077","https://openalex.org/W2033426968","https://openalex.org/W2039387657","https://openalex.org/W2048076272","https://openalex.org/W2049021766","https://openalex.org/W2051650157","https://openalex.org/W2053063136","https://openalex.org/W2062963040","https://openalex.org/W2074725298","https://openalex.org/W2077124451","https://openalex.org/W2080384555","https://openalex.org/W2098930896","https://openalex.org/W2138366743","https://openalex.org/W2409560152","https://openalex.org/W2429542833","https://openalex.org/W4256356608","https://openalex.org/W4298345797","https://openalex.org/W6844657685"],"related_works":["https://openalex.org/W1752727977","https://openalex.org/W2077124451","https://openalex.org/W2115588470","https://openalex.org/W2462451665","https://openalex.org/W2085904991","https://openalex.org/W2411718267","https://openalex.org/W2015408634","https://openalex.org/W2406758292","https://openalex.org/W1925574752","https://openalex.org/W214489188"],"abstract_inverted_index":{"Two":[0],"hundred":[1,34],"twenty-five":[2],"patients":[3,36],"with":[4,77,124],"active":[5],"severe":[6],"rheumatoid":[7],"arthritis":[8],"were":[9],"admitted":[10],"to":[11],"a":[12],"multiclinic,":[13],"controlled,":[14],"double-blind":[15],"trial":[16],"comparing":[17],"the":[18,54,71,78,90],"use":[19],"of":[20,42,62,81,95,103,118],"500":[21,45],"mg":[22,27,46],"D-penicillamine":[23,28,47,121],"per":[24,29],"day,":[25,30],"125":[26],"and":[31,67,110],"placebo.":[32],"One":[33],"seventy-one":[35],"completed":[37],"at":[38],"least":[39],"30":[40],"weeks":[41],"therapy.":[43],"The":[44,113],"group":[48,56],"demonstrated":[49],"statistically":[50,86],"significant":[51,87],"improvement":[52,76],"over":[53],"placebo":[55],"in":[57,93,116],"grip":[58],"strength,":[59],"average":[60],"circumference":[61],"swollen":[63,104,111],"proximal":[64],"interphalangeal":[65],"joints,":[66,105],"patient":[68],"assessment.":[69],"While":[70],"trend":[72],"was":[73,84,122],"for":[74,108],"greater":[75],"larger":[79],"dose":[80,120],"D-penicillamine,":[82],"there":[83],"no":[85],"difference":[88],"among":[89],"3":[91],"groups":[92],"duration":[94],"morning":[96],"stiffness,":[97],"walking":[98],"time,":[99],"physician's":[100],"assessment,":[101],"number":[102],"or":[106],"scores":[107],"tender":[109],"joints.":[112],"slight":[114],"increase":[115],"efficacy":[117],"higher":[119],"associated":[123],"increased":[125],"toxicity.":[126]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
