{"id":"https://openalex.org/W2093090639","doi":"https://doi.org/10.1021/ac000454e","title":"A Liquid Chromatography\u2212Mass Spectrometry Method for the Quantification of Bioavailability and Bioconversion of \u03b2-Carotene to Retinol in Humans","display_name":"A Liquid Chromatography\u2212Mass Spectrometry Method for the Quantification of Bioavailability and Bioconversion of \u03b2-Carotene to Retinol in Humans","publication_year":2000,"publication_date":"2000-08-24","ids":{"openalex":"https://openalex.org/W2093090639","doi":"https://doi.org/10.1021/ac000454e","mag":"2093090639","pmid":"https://pubmed.ncbi.nlm.nih.gov/11055721"},"language":"en","primary_location":{"id":"doi:10.1021/ac000454e","doi":"https://doi.org/10.1021/ac000454e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac000454e","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.wur.nl/en/publications/a-liquid-chromatography-mass-spectrometry-method-for-the-quantifi","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060542920","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-1187-9527","observed_orcids":["https://orcid.org/0000-0003-1187-9527","https://orcid.org/0000-0002-3144-8372"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoying Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Xiaoying Xu","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078192606","display_name":"Machteld Van Lieshout","orcid":"https://orcid.org/0009-0001-9954-589X","observed_orcids":["https://orcid.org/0009-0001-9954-589X"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Machteld van Lieshout","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111437693","display_name":"Clive E. West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Clive E. West","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082027918","display_name":"Johan Lugtenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Johan Lugtenburg","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028504673","display_name":"Michiel A. Verhoeven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Michiel A. Verhoeven","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000727779","display_name":"Alain F. L. Creemers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Alain F. L. Creemers","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Muhilal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Muhilal","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026872517","display_name":"Richard Bruce van Breemen","orcid":"https://orcid.org/0000-0003-2016-0063","observed_orcids":["https://orcid.org/0000-0003-2016-0063"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["NL","US"],"is_corresponding":true,"raw_author_name":"Richard B. van Breemen","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, Division of Human Nutrition & Epidemiology, Wageningen University, The Netherlands, Leiden Institute of Chemistry, Leiden University, The Netherlands, and Nutrition Research and Development Centre, JI Dr Sumeru 63, Bogor 16112, Indonesia","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026872517"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I39422238"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.6011,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.93239547,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"72","issue":"20","first_page":"4999","last_page":"5003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.38940000534057617,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.38940000534057617,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.2890999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.12389999628067017,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.9480000138282776},{"id":"https://openalex.org/keywords/retinol","display_name":"retinol","score":0.9890000224113464},{"id":"https://openalex.org/keywords/retinyl-palmitate","display_name":"retinyl palmitate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/carotenoid-bioavailability","display_name":"carotenoid bioavailability","score":0.800000011920929},{"id":"https://openalex.org/keywords/stable-isotope-labeling","display_name":"stable isotope labeling","score":0.5600000023841858},{"id":"https://openalex.org/keywords/serum-carotenoids","display_name":"serum carotenoids","score":0.6079999804496765},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.75},{"id":"https://openalex.org/keywords/vitamin-a-metabolism","display_name":"vitamin A metabolism","score":0.597000002861023},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9697688817977905},{"id":"https://openalex.org/C2780074830","wikidata":"https://www.wikidata.org/wiki/Q864423","display_name":"Bioconversion","level":3,"score":0.7907446622848511},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7790240049362183},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7507853507995605},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6476761102676392},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.5081682205200195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08491599559783936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.04742366075515747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019207","descriptor_name":"beta Carotene","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/ac000454e","doi":"https://doi.org/10.1021/ac000454e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac000454e","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:11055721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11055721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/66949","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/a-liquid-chromatography-mass-spectrometry-method-for-the-quantifi","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0003-2700","raw_type":"Article/Letter to editor"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/66949","doi":null,"is_oa":false,"landing_page_url":"https://research.wur.nl/en/publications/a-liquid-chromatography-mass-spectrometry-method-for-the-quantifi","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analytical Chemistry, 72(20), 4999 - 5003","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:library.wur.nl:wurpubs/66949","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/a-liquid-chromatography-mass-spectrometry-method-for-the-quantifi","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0003-2700","raw_type":"Article/Letter to editor"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6791068718","display_name":"CORE MASS SPECTROMETRY RESOURCE FOR CANCER RESEARCH","funder_award_id":"R24CA083124","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1995917451","https://openalex.org/W1998394710","https://openalex.org/W2033624890","https://openalex.org/W2049809250","https://openalex.org/W2050075231","https://openalex.org/W2060454872","https://openalex.org/W2124211672","https://openalex.org/W2143372963","https://openalex.org/W2160213245","https://openalex.org/W2188820569","https://openalex.org/W2311852706"],"related_works":["https://openalex.org/W2081623161","https://openalex.org/W2163108977","https://openalex.org/W6983038965","https://openalex.org/W2096040488","https://openalex.org/W1746909987","https://openalex.org/W2098258065","https://openalex.org/W2050075231","https://openalex.org/W2111999479","https://openalex.org/W1964977549","https://openalex.org/W2040494894"],"abstract_inverted_index":{"A":[0],"method":[1,250],"based":[2],"on":[3],"high-performance":[4],"liquid":[5],"chromatography-atmospheric":[6],"pressure":[7],"chemical":[8],"ionization":[9],"mass":[10,89],"spectrometry":[11],"(APCI":[12],"LC-MS)":[13],"was":[14,62,104,151,171],"developed":[15],"for":[16,95,119],"the":[17,20,28,132,147,161,186,191,220],"quantification":[18],"of":[19,22,30,39,54,107,124,135,149,163,188,194,209,214,222,234],"bioavailability":[21,257],"retinyl":[23],"palmitate":[24,41],"and":[25,27,42,51,60,65,71,76,142,178,204,219,236,239,258],"beta-carotene":[26,31,66,110,120,138,226,235,256],"bioconversion":[29,260],"to":[32,47,86,130,153,165,185,216,224,254,261],"retinol":[33,108,218,237,262],"in":[34],"humans.":[35],"Following":[36],"oral":[37],"administration":[38],"[8,9,10,11,12,13,14,15,19,20-13C10]-retinyl":[40],"[12,13,14,15,20,12',13',14',15',20'-13C10]-beta-carotene":[43],"at":[44,139,144,174,263],"physiological":[45],"doses":[46],"children":[48],"between":[49],"8":[50],"11":[52],"years":[53],"age,":[55],"blood":[56],"samples":[57],"were":[58,67,101,227],"drawn":[59],"serum":[61,73],"prepared.":[63],"Retinol":[64],"extracted":[68],"from":[69,190,200],"0.2-":[70],"1.0-mL":[72],"samples,":[74],"respectively,":[75],"analyzed":[77],"using":[78],"reversed-phase":[79],"HPLC":[80,232],"with":[81,230],"a":[82,115,240],"C30":[83],"column":[84],"interfaced":[85],"an":[87],"APCI":[88,112],"spectrometer.":[90],"Unlike":[91],"other":[92],"LC-MS":[93,113,249],"assays":[94],"carotenoids,":[96],"no":[97],"additional":[98],"purification":[99],"steps":[100],"necessary,":[102],"nor":[103],"any":[105],"derivatization":[106],"or":[109],"required.":[111],"showed":[114,245],"linear":[116],"detector":[117],"response":[118],"over":[121],"4":[122],"orders":[123],"magnitude.":[125],"Using":[126],"selected":[127,168],"ion":[128,169],"monitoring":[129,170],"record":[131],"elution":[133],"profile":[134],"protonated":[136,192],"circulating":[137,195],"m/z":[140,145,175],"537":[141],"[13C10]-beta-carotene":[143],"547,":[146],"limit":[148],"detection":[150],"determined":[152],"be":[154,252],"0.5":[155],"pmol":[156],"injected":[157],"on-column.":[158],"To":[159],"assess":[160],"ratio":[162,221],"labeled":[164,215,223],"unlabeled":[166,217,225],"retinol,":[167,196],"carried":[172],"out":[173],"269,":[176],"274,":[177],"279.":[179],"These":[180],"abundant":[181],"fragment":[182],"ions":[183],"corresponded":[184],"loss":[187],"water":[189],"molecule":[193],"[13C5]-retinol":[197],"(metabolically":[198],"formed":[199],"orally":[201],"administered":[202],"[13C10]-beta-carotene),":[203],"[13C10]-retinol":[205],"(formed":[206],"by":[207],"hydrolysis":[208],"[13C10]-retinyl":[210],"palmitate).":[211],"The":[212],"ratios":[213],"calculated.":[228],"Combined":[229],"standard":[231],"measurement":[233],"concentration":[238],"mathematical":[241],"model,":[242],"these":[243],"results":[244],"that":[246],"this":[247],"simple":[248],"can":[251],"used":[253],"quantify":[255],"its":[259],"physiologically":[264],"relevant":[265],"doses.":[266]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}