{"id":"https://openalex.org/W2093056513","doi":"https://doi.org/10.1002/jbm.a.30016","title":"Differentiation of preosteoblasts is affected by implant surface microtopographies","display_name":"Differentiation of preosteoblasts is affected by implant surface microtopographies","publication_year":2004,"publication_date":"2004-03-11","ids":{"openalex":"https://openalex.org/W2093056513","doi":"https://doi.org/10.1002/jbm.a.30016","mag":"2093056513","pmid":"https://pubmed.ncbi.nlm.nih.gov/15127393"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.30016","doi":"https://doi.org/10.1002/jbm.a.30016","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30016","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055083596","display_name":"Galen B. Schneider","orcid":"https://orcid.org/0009-0001-2035-2981","observed_orcids":["https://orcid.org/0009-0001-2035-2981"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Galen B. Schneider","raw_affiliation_strings":["Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050638843","display_name":"Rebecca S. Zaharias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Zaharias","raw_affiliation_strings":["Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085882250","display_name":"Denise Seabold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Seabold","raw_affiliation_strings":["Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111865561","display_name":"John C. Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Keller","raw_affiliation_strings":["Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022721108","display_name":"Clark M. Stanford","orcid":"https://orcid.org/0000-0001-5449-1210","observed_orcids":["https://orcid.org/0000-0001-5449-1210"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clark Stanford","raw_affiliation_strings":["Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dows Institute for Dental Research and the Department of Prosthodontics, N402, University of Iowa College of Dentistry, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055083596"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":3.9982,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.93272936,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"69A","issue":"3","first_page":"462","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.20100000500679016,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preosteoblast-differentiation","display_name":"preosteoblast differentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/osteocalcin-gene-expression","display_name":"osteocalcin gene expression","score":0.9089999794960022},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dental-implants","display_name":"dental implants","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cell-mineralization","display_name":"cell mineralization","score":0.6039999723434448},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.49900001287460327},{"id":"https://openalex.org/keywords/surface-roughness","display_name":"surface roughness","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.8816380500793457},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.8163988590240479},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6857258677482605},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6723705530166626},{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.6032383441925049},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5482327938079834},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4947652220726013},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43414804339408875},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4194514751434326},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3959249258041382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3331550359725952},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32653582096099854},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2367870807647705},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.23117035627365112},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20249834656715393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16518685221672058},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09000071883201599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06283611059188843},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050656","descriptor_name":"Transcription Factor AP-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.30016","doi":"https://doi.org/10.1002/jbm.a.30016","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30016","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:15127393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15127393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6192077472","display_name":"Mineralization: Integrins and Focal Adhesion Kinase","funder_award_id":"R03DE014269","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G937760714","display_name":"COMPREHENSIVE PROGRAM FOR CRANIOFACIAL &DENTAL ANOMALIE","funder_award_id":"P60DE013076","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1776717194","https://openalex.org/W1975573720","https://openalex.org/W1979700688","https://openalex.org/W1990104353","https://openalex.org/W1994596418","https://openalex.org/W1996013872","https://openalex.org/W1997812904","https://openalex.org/W2030347996","https://openalex.org/W2032342275","https://openalex.org/W2033514910","https://openalex.org/W2034984922","https://openalex.org/W2045012301","https://openalex.org/W2052359540","https://openalex.org/W2059906854","https://openalex.org/W2071413607","https://openalex.org/W2080511423","https://openalex.org/W2084776852","https://openalex.org/W2120977989","https://openalex.org/W2130516299","https://openalex.org/W2143950663","https://openalex.org/W2144268541","https://openalex.org/W2151005356","https://openalex.org/W2155442777","https://openalex.org/W2159999899","https://openalex.org/W2161469883","https://openalex.org/W2162467077","https://openalex.org/W2168346484","https://openalex.org/W2172294715","https://openalex.org/W2415929326","https://openalex.org/W3025174573","https://openalex.org/W4299669929"],"related_works":["https://openalex.org/W2521047833","https://openalex.org/W7034765078","https://openalex.org/W2045728316","https://openalex.org/W2030347996","https://openalex.org/W2765250761","https://openalex.org/W2765806933","https://openalex.org/W1900723829","https://openalex.org/W2112922772","https://openalex.org/W2112556082","https://openalex.org/W2908445449"],"abstract_inverted_index":{"Osteogenesis":[0],"involves":[1],"the":[2,9,30],"recruitment":[3],"of":[4,12,26,32,38,91,151],"multipotent":[5],"mesenchymal":[6,64],"cells":[7,14,65,98,128],"and":[8,24,51,93,104,123,132],"progressive":[10],"differentiation":[11,23,47,142],"these":[13],"into":[15],"osteoblasts.":[16],"The":[17,36],"transcription":[18],"factor":[19],"Runx2":[20,50,92,122],"regulates":[21],"osteoblast":[22],"expression":[25,54,126],"genes":[27],"necessary":[28],"for":[29,88],"development":[31],"a":[33],"mineralized":[34,99],"phenotype.":[35],"purpose":[37],"this":[39],"study":[40],"was":[41,55,86],"to":[42,109],"determine":[43],"if":[44],"preosteoblast":[45,140],"cell":[46,141],"associated":[48],"with":[49,81],"osteocalcin":[52,94,124],"gene":[53,95,125],"influenced":[56],"by":[57,145],"implant":[58,75,106,134,146],"surface":[59,147],"microtopography.":[60],"Human":[61],"embryonic":[62],"palatal":[63],"(HEPM":[66],"cells)":[67],"were":[68,79],"cultured":[69,129],"on":[70,102,130],"grooved":[71,105,133],"or":[72],"roughened":[73],"cpTi":[74],"discs.":[76],"Cell":[77],"phenotypes":[78],"evaluated":[80],"epifluorescent":[82],"microscopy.":[83],"Real-time":[84,113],"PCR":[85,114],"used":[87],"quantitative":[89],"analysis":[90],"expression.":[96],"HEPM":[97],"when":[100],"grown":[101],"rough":[103,131],"surfaces":[107],"relative":[108],"tissue":[110],"culture":[111],"plastic.":[112],"showed":[115],"significant":[116],"(p":[117],"<":[118],"0.05)":[119],"increases":[120],"in":[121,127],"microtopographies.":[135],"These":[136],"results":[137],"suggest":[138],"that":[139],"is":[143],"affected":[144],"microtopographies":[148],"during":[149],"osseointegration":[150],"dental":[152],"implants.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
