{"id":"https://openalex.org/W2093046930","doi":"https://doi.org/10.1371/journal.pone.0087342","title":"Species D Human Adenovirus Type 9 Exhibits Better Virus-Spread Ability for Antitumor Efficacy among Alternative Serotypes","display_name":"Species D Human Adenovirus Type 9 Exhibits Better Virus-Spread Ability for Antitumor Efficacy among Alternative Serotypes","publication_year":2014,"publication_date":"2014-02-04","ids":{"openalex":"https://openalex.org/W2093046930","doi":"https://doi.org/10.1371/journal.pone.0087342","mag":"2093046930","pmid":"https://pubmed.ncbi.nlm.nih.gov/24503714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913592"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0087342","doi":"https://doi.org/10.1371/journal.pone.0087342","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087342","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087342&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087342&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006132661","display_name":"Junji Uchino","orcid":"https://orcid.org/0000-0003-0651-7767","observed_orcids":["https://orcid.org/0000-0003-0651-7767"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junji Uchino","raw_affiliation_strings":["Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Curiel","raw_affiliation_strings":["Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America ; Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America ; Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074722199","display_name":"Hideyo Ugai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hideyo Ugai","raw_affiliation_strings":["Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074722199"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5202,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65141329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"2","first_page":"e87342","last_page":"e87342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-serotypes","display_name":"adenovirus serotypes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/virus-transmission","display_name":"virus transmission","score":0.5379999876022339},{"id":"https://openalex.org/keywords/viral-tropism","display_name":"viral tropism","score":0.6259999871253967},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.625},{"id":"https://openalex.org/keywords/adenovirus-receptor","display_name":"adenovirus receptor","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.7644917964935303},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7584718465805054},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6656540632247925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6572789549827576},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.6551685929298401},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5940961837768555},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.5664422512054443},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.548259973526001},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.48501822352409363},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4694497287273407},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.4660426676273346},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46446293592453003},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4469430446624756},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4264335632324219},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.41634976863861084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2035500705242157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05181819200515747},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000258","descriptor_name":"Adenovirus Infections, Human","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000258","descriptor_name":"Adenovirus Infections, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062727","descriptor_name":"Coxsackie and Adenovirus Receptor-Like Membrane Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0087342","doi":"https://doi.org/10.1371/journal.pone.0087342","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087342","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087342&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2901061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3913592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24503714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24503714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-3851","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/2848","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=3851&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0a2c520e8c2c4dedaf0a4544e495979b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a2c520e8c2c4dedaf0a4544e495979b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 2, p e87342 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/925752","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Species_D_Human_Adenovirus_Type_9_Exhibits_Better_Virus_Spread_Ability_for_Antitumor_Efficacy_among_Alternative_Serotypes_/925752","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0087342","doi":"https://doi.org/10.1371/journal.pone.0087342","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087342","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087342&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3610702199","display_name":"Targeted-and Image-Based Adenovirus Cancer Therapeutic Vectors","funder_award_id":"R01CA154697","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7632986857","display_name":null,"funder_award_id":"KG100194","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2093046930.pdf","grobid_xml":"https://content.openalex.org/works/W2093046930.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W106173202","https://openalex.org/W1486444466","https://openalex.org/W1492027627","https://openalex.org/W1507561841","https://openalex.org/W1539803330","https://openalex.org/W1540542144","https://openalex.org/W1544229812","https://openalex.org/W1560044106","https://openalex.org/W1579265529","https://openalex.org/W1766634805","https://openalex.org/W1809188197","https://openalex.org/W1938253145","https://openalex.org/W1943398466","https://openalex.org/W1950423469","https://openalex.org/W1963910714","https://openalex.org/W1971352949","https://openalex.org/W1973637021","https://openalex.org/W1981755236","https://openalex.org/W1985004056","https://openalex.org/W1985643577","https://openalex.org/W1986509391","https://openalex.org/W1991711054","https://openalex.org/W1994217611","https://openalex.org/W1997903266","https://openalex.org/W1998150511","https://openalex.org/W2000743125","https://openalex.org/W2004109703","https://openalex.org/W2008078589","https://openalex.org/W2009360710","https://openalex.org/W2009535263","https://openalex.org/W2011195144","https://openalex.org/W2011337319","https://openalex.org/W2011853077","https://openalex.org/W2012714016","https://openalex.org/W2013818959","https://openalex.org/W2015198791","https://openalex.org/W2017060382","https://openalex.org/W2021667186","https://openalex.org/W2026841968","https://openalex.org/W2027213473","https://openalex.org/W2028068426","https://openalex.org/W2029437600","https://openalex.org/W2037262542","https://openalex.org/W2038427698","https://openalex.org/W2039084800","https://openalex.org/W2041538671","https://openalex.org/W2051758487","https://openalex.org/W2057782643","https://openalex.org/W2078455874","https://openalex.org/W2079523736","https://openalex.org/W2089157311","https://openalex.org/W2089370460","https://openalex.org/W2093134342","https://openalex.org/W2093665892","https://openalex.org/W2096232093","https://openalex.org/W2098599316","https://openalex.org/W2098599594","https://openalex.org/W2102099335","https://openalex.org/W2102807955","https://openalex.org/W2106503298","https://openalex.org/W2108140735","https://openalex.org/W2116152286","https://openalex.org/W2116175479","https://openalex.org/W2125226029","https://openalex.org/W2127342004","https://openalex.org/W2139248662","https://openalex.org/W2143242059","https://openalex.org/W2143540262","https://openalex.org/W2144512912","https://openalex.org/W2144634347","https://openalex.org/W2146108709","https://openalex.org/W2146415292","https://openalex.org/W2147649350","https://openalex.org/W2153792353","https://openalex.org/W2157806347","https://openalex.org/W2158529706","https://openalex.org/W2159913430","https://openalex.org/W2165948908","https://openalex.org/W2169359328","https://openalex.org/W2169962588","https://openalex.org/W2178296037","https://openalex.org/W2180993978","https://openalex.org/W2262829041","https://openalex.org/W2313228602","https://openalex.org/W2322389503","https://openalex.org/W3196006275","https://openalex.org/W4211126864","https://openalex.org/W4211238487","https://openalex.org/W4244980457","https://openalex.org/W6633658626"],"related_works":["https://openalex.org/W1998150511","https://openalex.org/W2145448937","https://openalex.org/W2042164584","https://openalex.org/W7123589725","https://openalex.org/W4241796100","https://openalex.org/W2080607028","https://openalex.org/W1992351692","https://openalex.org/W1570572022","https://openalex.org/W7208130647","https://openalex.org/W2561215844"],"abstract_inverted_index":{"Species":[0],"C":[1],"human":[2,174],"adenovirus":[3,163],"serotype":[4],"5":[5],"(HAdV-C5)":[6],"is":[7,75,99],"widely":[8],"used":[9],"as":[10,188,190],"a":[11,66,155],"vector":[12],"for":[13,38,101,123,158,170],"cancer":[14,39,54,103,186,192],"gene":[15,40,104],"therapy,":[16],"because":[17],"it":[18],"efficiently":[19,141],"transduces":[20],"target":[21,179],"cells.":[22,86,180,193],"A":[23,69,120],"variety":[24],"of":[25,57,81],"HAdV-C5":[26,46,58,82,111],"vectors":[27,47,59,83],"have":[28,205],"been":[29],"developed":[30],"and":[31,35,136,162],"tested":[32],"in":[33,36,49,52,65,72,126,209],"vitro":[34],"vivo":[37],"therapy.":[41,105],"While":[42],"clinical":[43],"trials":[44],"with":[45,199],"resulted":[48],"effective":[50],"responses":[51,64],"many":[53],"patients,":[55],"administration":[56],"to":[60,77,95,112,121,173,178,213],"solid":[61,210],"tumors":[62,211],"showed":[63,129,167],"limited":[67],"area.":[68],"biological":[70],"barrier":[71],"tumor":[73,93,97],"mass":[74],"considered":[76],"hinder":[78],"viral":[79,138,147],"spread":[80],"from":[84,90,118,143],"infected":[85,92,144],"Therefore,":[87],"efficient":[88],"virus-spread":[89,124,131,202],"an":[91],"cell":[94],"surrounding":[96],"cells":[98,145,187],"required":[100],"successful":[102],"In":[106],"this":[107],"study,":[108],"we":[109],"compared":[110,212],"sixteen":[113],"other":[114,134],"HAdV":[115],"serotypes":[116],"selected":[117],"species":[119],"G":[122],"ability":[125,132],"vitro.":[127],"HAdV-D9":[128,151,166,181],"better":[130,201],"than":[133],"serotypes,":[135],"its":[137,200],"progeny":[139],"were":[140],"released":[142],"during":[146],"replication.":[148],"Although":[149],"the":[150],"fiber":[152],"protein":[153],"contains":[154],"binding":[156],"site":[157],"coxsackie":[159],"B":[160],"virus":[161],"receptor":[164],"(CAR),":[165],"expanded":[168],"tropism":[169],"infection":[171,182],"due":[172],"CAR":[175],"(hCAR)-independent":[176],"attachment":[177],"effectively":[183],"killed":[184],"hCAR-negative":[185],"well":[189],"hCAR-positive":[191],"These":[194],"results":[195],"suggest":[196],"that":[197],"HADV-D9,":[198],"ability,":[203],"could":[204],"improved":[206],"therapeutic":[207],"efficacy":[208],"HAdV-C5.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}