{"id":"https://openalex.org/W2092986751","doi":"https://doi.org/10.1021/bi050745n","title":"DNA Minor Groove Adducts Formed by a Platinum\u2212Acridine Conjugate Inhibit Association of TATA-Binding Protein with Its Cognate Sequence","display_name":"DNA Minor Groove Adducts Formed by a Platinum\u2212Acridine Conjugate Inhibit Association of TATA-Binding Protein with Its Cognate Sequence","publication_year":2005,"publication_date":"2005-07-30","ids":{"openalex":"https://openalex.org/W2092986751","doi":"https://doi.org/10.1021/bi050745n","mag":"2092986751","pmid":"https://pubmed.ncbi.nlm.nih.gov/16101310"},"language":"en","primary_location":{"id":"doi:10.1021/bi050745n","doi":"https://doi.org/10.1021/bi050745n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi050745n","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060886321","display_name":"Michael E. Budiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Budiman","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109","Department of Chemistry, Wake Forest University, P.O. Box 7486 Reynolda Station, Winston-Salem, North Carolina 27109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, P.O. Box 7486 Reynolda Station, Winston-Salem, North Carolina 27109, USA","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047085422","display_name":"Ulrich Bierbach","orcid":"https://orcid.org/0000-0001-5658-7662","observed_orcids":["https://orcid.org/0000-0001-5658-7662"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrich Bierbach","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049669217","display_name":"Rebecca W. Alexander","orcid":"https://orcid.org/0000-0002-9159-6991","observed_orcids":["https://orcid.org/0000-0002-9159-6991"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca W. Alexander","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, P.O. Box 7486, Reynolda Station, Winston-Salem, North Carolina 27109","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47251452"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.9326,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.7549936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"33","first_page":"11262","last_page":"11268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.8999999761581421},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/photo-crosslinking","display_name":"photocrosslinking","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C3019303373","wikidata":"https://www.wikidata.org/wiki/Q60535862","display_name":"Minor groove","level":3,"score":0.794767439365387},{"id":"https://openalex.org/C2776924795","wikidata":"https://www.wikidata.org/wiki/Q342713","display_name":"Acridine","level":2,"score":0.6940827965736389},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.6436395049095154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6289960145950317},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5921028852462769},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5785546898841858},{"id":"https://openalex.org/C518104683","wikidata":"https://www.wikidata.org/wiki/Q880","display_name":"Platinum","level":3,"score":0.5219837427139282},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4829903841018677},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42521175742149353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3555203080177307},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3355555832386017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2436809539794922},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07446742057800293},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D035181","descriptor_name":"TATA-Box Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035181","descriptor_name":"TATA-Box Binding Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi050745n","doi":"https://doi.org/10.1021/bi050745n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi050745n","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:16101310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16101310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5180496564","display_name":"Novel DNA-metalating Hybrid Anticancer Agents","funder_award_id":"R01CA101880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6229218287","display_name":null,"funder_award_id":"CA101880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W107832641","https://openalex.org/W1512601207","https://openalex.org/W1532634227","https://openalex.org/W1601384284","https://openalex.org/W1935774199","https://openalex.org/W1964377470","https://openalex.org/W1978775814","https://openalex.org/W1983338915","https://openalex.org/W1984665941","https://openalex.org/W1987940280","https://openalex.org/W1989062285","https://openalex.org/W1991718491","https://openalex.org/W1993384720","https://openalex.org/W2004912100","https://openalex.org/W2008561807","https://openalex.org/W2016788237","https://openalex.org/W2017905372","https://openalex.org/W2022631460","https://openalex.org/W2026384032","https://openalex.org/W2028130329","https://openalex.org/W2032864324","https://openalex.org/W2035485234","https://openalex.org/W2035797443","https://openalex.org/W2040256004","https://openalex.org/W2043610941","https://openalex.org/W2045551987","https://openalex.org/W2053114161","https://openalex.org/W2054139878","https://openalex.org/W2056470381","https://openalex.org/W2057541073","https://openalex.org/W2057638760","https://openalex.org/W2059128931","https://openalex.org/W2062130291","https://openalex.org/W2071624268","https://openalex.org/W2077594563","https://openalex.org/W2078049644","https://openalex.org/W2089019299","https://openalex.org/W2090995659","https://openalex.org/W2091443216","https://openalex.org/W2093282189","https://openalex.org/W2098919421","https://openalex.org/W2120531597","https://openalex.org/W2120853161","https://openalex.org/W2123325956","https://openalex.org/W2138365701","https://openalex.org/W2145013380","https://openalex.org/W2156736748","https://openalex.org/W2164277862","https://openalex.org/W2165608108","https://openalex.org/W2343891719"],"related_works":["https://openalex.org/W2047318837","https://openalex.org/W2016788237","https://openalex.org/W2091443216","https://openalex.org/W1986237432","https://openalex.org/W2145013380","https://openalex.org/W2017905372","https://openalex.org/W2054139878","https://openalex.org/W2017567726","https://openalex.org/W2017803202","https://openalex.org/W6989842762"],"abstract_inverted_index":{"PT-ACRAMTU":[0,85,169,190],"([PtCl(en)(ACRAMTU-S)](NO(3))(2),":[1],"en":[2],"=":[3,6],"ethane-1,2-diamine,":[4],"ACRAMTU":[5],"1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea)":[7],"is":[8],"a":[9,73,110,129],"cytotoxic":[10],"platinum-acridine":[11],"conjugate":[12],"previously":[13],"shown":[14],"to":[15,49,68,145,188,192],"form":[16],"adducts":[17,54,86,167,214],"with":[18,132],"the":[19,26,38,44,70,88,92,171,185,194],"N3":[20],"endocyclic":[21],"nitrogen":[22],"of":[23,37,43,52,72,84,91,100,116,152,168,173,184,199,210],"adenine":[24],"in":[25,87,109,128],"DNA":[27,56,187,201],"minor":[28,57,89,105,165,212],"groove.":[29],"This":[30,175],"unusual":[31],"observation":[32],"and":[33,104,134],"our":[34],"prior":[35],"determination":[36],"pronounced":[39],"5'-TA/TA":[40],"base-step":[41],"affinity":[42],"drug":[45,197],"have":[46],"prompted":[47],"us":[48],"investigate":[50],"effects":[51],"these":[53],"on":[55,123,160],"groove":[58,90,103,106,166,213],"binding":[59,107,125,138,154],"proteins.":[60],"Here,":[61],"we":[62],"used":[63],"electrophoretic":[64],"mobility":[65],"shift":[66],"assays":[67],"study":[69],"recognition":[71],"PT-ACRAMTU-modified":[74],"TATA":[75,93],"box":[76,94],"sequence":[77,113],"by":[78,97,139,180],"TATA-binding":[79],"protein":[80],"(TBP).":[81],"The":[82,119,207],"frequency":[83],"was":[95,126,177],"varied":[96],"selective":[98],"elimination":[99,151],"potential":[101],"major":[102],"sites":[108,155],"24-bp":[111],"probe":[112],"through":[114],"incorporation":[115],"deaza":[117],"nucleobases.":[118],"most":[120],"dramatic":[121],"effect":[122,159],"TBP":[124,161],"observed":[127],"duplex":[130],"substituted":[131],"7-deaza-G":[133],"7-deaza-A,":[135],"which":[136],"reduced":[137],"as":[140,142],"much":[141],"73%":[143],"compared":[144],"an":[146],"unplatinated":[147],"duplex.":[148],"In":[149],"contrast,":[150],"A-N3":[153],"had":[156],"no":[157],"significant":[158],"binding,":[162],"suggesting":[163],"that":[164],"are":[170,215],"cause":[172],"inhibition.":[174],"notion":[176],"further":[178],"corroborated":[179],"efficient":[181],"platinum-mediated":[182],"photo-cross-linking":[183],"drug-modified":[186],"TBP.":[189],"appears":[191],"be":[193],"first":[195],"platinum-based":[196],"capable":[198],"targeting":[200],"sequences":[202],"critical":[203],"for":[204],"transcription":[205],"initiation.":[206],"biological":[208],"consequences":[209],"PT-ACRAMTU's":[211],"discussed.":[216]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}