{"id":"https://openalex.org/W2092986472","doi":"https://doi.org/10.1016/0165-1781(82)90040-3","title":"Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls","display_name":"Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls","publication_year":1982,"publication_date":"1982-02-01","ids":{"openalex":"https://openalex.org/W2092986472","doi":"https://doi.org/10.1016/0165-1781(82)90040-3","mag":"2092986472","pmid":"https://pubmed.ncbi.nlm.nih.gov/6173891"},"language":"en","primary_location":{"id":"doi:10.1016/0165-1781(82)90040-3","doi":"https://doi.org/10.1016/0165-1781(82)90040-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1781(82)90040-3","pdf_url":null,"source":{"id":"https://openalex.org/S84074229","display_name":"Psychiatry Research","issn_l":"0165-1781","issn":["0165-1781","1872-7123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111567063","display_name":"Leif Bertilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Leif Bertilsson","raw_affiliation_strings":["Leif Bertilsson, Ph.D., and Gunnel Tybring, Engr., are at the Department of Clinical Pharmacology, and Ole Lantto, M.Sci., is at the Department of Clinical Chemistry, Karolinska Institute (Hudding Hospital), S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leif Bertilsson, Ph.D., and Gunnel Tybring, Engr., are at the Department of Clinical Pharmacology, and Ole Lantto, M.Sci., is at the Department of Clinical Chemistry, Karolinska Institute (Hudding Hospital), S-141 86 Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086696148","display_name":"Marie \u00c5sberg","orcid":"https://orcid.org/0000-0001-5738-0655","observed_orcids":["https://orcid.org/0000-0001-5738-0655"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marie \u00c5sberg","raw_affiliation_strings":["Lil Tr\u00e4skman-Bendz, M.D., and Marie \u00c5sberg, M.D., are at the Department of Psychiatry, Karolinska Institute (Karolinska Hospital), S-104 01 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lil Tr\u00e4skman-Bendz, M.D., and Marie \u00c5sberg, M.D., are at the Department of Psychiatry, Karolinska Institute (Karolinska Hospital), S-104 01 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018383347","display_name":"Olle Lantto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olle Lantto","raw_affiliation_strings":["Leif Bertilsson, Ph.D., and Gunnel Tybring, Engr., are at the Department of Clinical Pharmacology, and Ole Lantto, M.Sci., is at the Department of Clinical Chemistry, Karolinska Institute (Hudding Hospital), S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leif Bertilsson, Ph.D., and Gunnel Tybring, Engr., are at the Department of Clinical Pharmacology, and Ole Lantto, M.Sci., is at the Department of Clinical Chemistry, Karolinska Institute (Hudding Hospital), S-141 86 Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083047235","display_name":"Gianpaolo Scalia\u2010Tomba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gian-Paolo Scalia-Tomba","raw_affiliation_strings":["Gian-Paolo Scalia-Tomba, B.Sci., is at the Department of Mathematical Statistics, University of Stockholm, S-113 85 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gian-Paolo Scalia-Tomba, B.Sci., is at the Department of Mathematical Statistics, University of Stockholm, S-113 85 Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077632427","display_name":"Lil Tr\u00e4skman\u2010Bendz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lil Tr\u00e4skman-Bendz","raw_affiliation_strings":["Lil Tr\u00e4skman-Bendz, M.D., and Marie \u00c5sberg, M.D., are at the Department of Psychiatry, Karolinska Institute (Karolinska Hospital), S-104 01 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lil Tr\u00e4skman-Bendz, M.D., and Marie \u00c5sberg, M.D., are at the Department of Psychiatry, Karolinska Institute (Karolinska Hospital), S-104 01 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038555087","display_name":"Gunnel Tybring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunnel Tybring","raw_affiliation_strings":["Leif Bertilsson, Ph.D., and Gunnel Tybring, Engr., are at the Department of Clinical Pharmacology, and Ole Lantto, M.Sci., is at the Department of Clinical Chemistry, Karolinska Institute (Hudding Hospital), S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leif Bertilsson, Ph.D., and Gunnel Tybring, Engr., are at the Department of Clinical Pharmacology, and Ole Lantto, M.Sci., is at the Department of Clinical Chemistry, Karolinska Institute (Hudding Hospital), S-141 86 Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111567063"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4230,"currency":"USD","value_usd":4230},"apc_paid":null,"fwci":3.3923,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.89690722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"6","issue":"1","first_page":"77","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.47920000553131104,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.47920000553131104,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-metabolites","display_name":"monoamine metabolites","score":0.871999979019165},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.734000027179718},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.921999990940094},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":1.0},{"id":"https://openalex.org/keywords/mhpg","display_name":"MHPG","score":0.9879999756813049},{"id":"https://openalex.org/keywords/concentration-gradient","display_name":"concentration gradient","score":0.7540000081062317},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.734000027179718},{"id":"https://openalex.org/keywords/psychiatric-patients","display_name":"psychiatric patients","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8281405568122864},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.7895634174346924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.512628972530365},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5032829642295837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44556745886802673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39665642380714417},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3667452335357666},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.17916616797447205},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D006018","descriptor_name":"Glycols","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-1781(82)90040-3","doi":"https://doi.org/10.1016/0165-1781(82)90040-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1781(82)90040-3","pdf_url":null,"source":{"id":"https://openalex.org/S84074229","display_name":"Psychiatry Research","issn_l":"0165-1781","issn":["0165-1781","1872-7123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry Research","raw_type":"journal-article"},{"id":"pmid:6173891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6173891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W24233331","https://openalex.org/W1964792484","https://openalex.org/W1978250818","https://openalex.org/W1978773368","https://openalex.org/W1991735971","https://openalex.org/W1996115568","https://openalex.org/W2000277154","https://openalex.org/W2035936600","https://openalex.org/W2071480913","https://openalex.org/W2080453038","https://openalex.org/W2080889861","https://openalex.org/W2081371398","https://openalex.org/W2081678546","https://openalex.org/W2082370044","https://openalex.org/W2092837465","https://openalex.org/W2094109562","https://openalex.org/W2105758627","https://openalex.org/W2131823335","https://openalex.org/W2163833570","https://openalex.org/W2169273936","https://openalex.org/W2200560545","https://openalex.org/W2410749050","https://openalex.org/W2415273132","https://openalex.org/W2417095289","https://openalex.org/W4247864709"],"related_works":["https://openalex.org/W2030246458","https://openalex.org/W7096235643","https://openalex.org/W4320489668","https://openalex.org/W2113449693","https://openalex.org/W2036602098","https://openalex.org/W1989218867","https://openalex.org/W2001969466","https://openalex.org/W2132168503","https://openalex.org/W2051858230","https://openalex.org/W6939795584"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}