{"id":"https://openalex.org/W2092985682","doi":"https://doi.org/10.1371/journal.pgen.0020066","title":"The Polycomb Group Protein EED Is Dispensable for the Initiation of Random X-Chromosome Inactivation","display_name":"The Polycomb Group Protein EED Is Dispensable for the Initiation of Random X-Chromosome Inactivation","publication_year":2006,"publication_date":"2006-04-28","ids":{"openalex":"https://openalex.org/W2092985682","doi":"https://doi.org/10.1371/journal.pgen.0020066","mag":"2092985682","pmid":"https://pubmed.ncbi.nlm.nih.gov/16680199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1456320"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.0020066","doi":"https://doi.org/10.1371/journal.pgen.0020066","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0020066","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020066&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020066&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060877343","display_name":"Sundeep Kalantry","orcid":"https://orcid.org/0000-0003-0763-8050","observed_orcids":["https://orcid.org/0000-0003-0763-8050"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sundeep Kalantry","raw_affiliation_strings":["Department of Genetics and the Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and the Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009863015","display_name":"Terry Magnuson","orcid":"https://orcid.org/0000-0002-0792-835X","observed_orcids":["https://orcid.org/0000-0002-0792-835X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terry Magnuson","raw_affiliation_strings":["Department of Genetics and the Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and the Carolina Center for the Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009863015"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":5.2597,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.96400997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"5","first_page":"e66","last_page":"e66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.23600000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.8420000076293945},{"id":"https://openalex.org/keywords/eed","display_name":"EED","score":0.9649999737739563},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.7509999871253967},{"id":"https://openalex.org/keywords/facultative-heterochromatin","display_name":"facultative heterochromatin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/inactive-x-chromosome","display_name":"inactive X chromosome","score":0.6660000085830688},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7059999704360962},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.80507892370224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.800017237663269},{"id":"https://openalex.org/C4323932","wikidata":"https://www.wikidata.org/wiki/Q898914","display_name":"X-inactivation","level":4,"score":0.7692129611968994},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6038161516189575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5826259851455688},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.5598724484443665},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5422435998916626},{"id":"https://openalex.org/C110411900","wikidata":"https://www.wikidata.org/wiki/Q18032385","display_name":"XIST","level":5,"score":0.5137301683425903},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.5071916580200195},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.43222394585609436},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.41504889726638794},{"id":"https://openalex.org/C35158069","wikidata":"https://www.wikidata.org/wiki/Q61333","display_name":"X chromosome","level":3,"score":0.3517995774745941},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.24187108874320984},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.2355111539363861},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2241027057170868},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14325383305549622},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.1033812165260315}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049951","descriptor_name":"X Chromosome Inactivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pgen.0020066","doi":"https://doi.org/10.1371/journal.pgen.0020066","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0020066","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020066&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2622023","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1456320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1456320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1456320","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:16680199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16680199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:9s161f604","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/n9xm-pj05","pdf_url":"https://doi.org/10.17615/n9xm-pj05","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, 2(5)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.2409","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.2409","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/df/d4/PLoS_Genet_2006_May_5_2(5)_e66.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b86e7d6478db4d1b8ab235351325b7a6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b86e7d6478db4d1b8ab235351325b7a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 2, Iss 5, p e66 (2006)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f0b472e4ee184afb98e0b10d9d934d15","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f0b472e4ee184afb98e0b10d9d934d15","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 2, Iss 5, p e66 (2006)","raw_type":"article"},{"id":"doi:10.17615/n9xm-pj05","doi":"https://doi.org/10.17615/n9xm-pj05","is_oa":true,"landing_page_url":"https://doi.org/10.17615/n9xm-pj05","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.0020066","doi":"https://doi.org/10.1371/journal.pgen.0020066","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0020066","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020066&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7171926574","display_name":"ALBINO DELETION COMPLEX AND EARLY MOUSE DEVELOPMENT","funder_award_id":"R01HD024462","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092985682.pdf","grobid_xml":"https://content.openalex.org/works/W2092985682.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1516724560","https://openalex.org/W1535914077","https://openalex.org/W1608345078","https://openalex.org/W1977312189","https://openalex.org/W1977364126","https://openalex.org/W1978287692","https://openalex.org/W1978429719","https://openalex.org/W1986801877","https://openalex.org/W1987583896","https://openalex.org/W2009456720","https://openalex.org/W2010673383","https://openalex.org/W2015132841","https://openalex.org/W2018158796","https://openalex.org/W2021122622","https://openalex.org/W2022686144","https://openalex.org/W2029146706","https://openalex.org/W2035000127","https://openalex.org/W2041690382","https://openalex.org/W2049780043","https://openalex.org/W2056156549","https://openalex.org/W2064358462","https://openalex.org/W2067583299","https://openalex.org/W2075087486","https://openalex.org/W2079597045","https://openalex.org/W2083513924","https://openalex.org/W2088639474","https://openalex.org/W2095002834","https://openalex.org/W2099848129","https://openalex.org/W2101943126","https://openalex.org/W2103419911","https://openalex.org/W2107011634","https://openalex.org/W2110241629","https://openalex.org/W2110576356","https://openalex.org/W2111473969","https://openalex.org/W2118681186","https://openalex.org/W2123066359","https://openalex.org/W2129860979","https://openalex.org/W2130089202","https://openalex.org/W2135748193","https://openalex.org/W2137808356","https://openalex.org/W2140075682","https://openalex.org/W2154284135","https://openalex.org/W2165894156","https://openalex.org/W2171756746","https://openalex.org/W2295165738","https://openalex.org/W6992757371"],"related_works":["https://openalex.org/W7095457196","https://openalex.org/W2934218499","https://openalex.org/W6977513675","https://openalex.org/W6977211458","https://openalex.org/W6977255249","https://openalex.org/W6958272987","https://openalex.org/W6940132571","https://openalex.org/W4255171903","https://openalex.org/W1978429719","https://openalex.org/W4294882697"],"abstract_inverted_index":{"The":[0,14],"Polycomb":[1,15],"group":[2],"(PcG)":[3],"proteins":[4,99,165],"are":[5,100],"thought":[6,117],"to":[7,32,66,69,121,188,204],"silence":[8],"gene":[9,35],"expression":[10],"by":[11,159],"modifying":[12],"chromatin.":[13],"repressive":[16],"complex":[17],"2":[18],"(PRC2)":[19],"plays":[20],"an":[21],"essential":[22,130],"role":[23],"in":[24,136,142,150,166,226,233],"mammalian":[25],"X-chromosome":[26,58,82],"inactivation":[27,54],"(XCI),":[28],"a":[29],"model":[30],"system":[31],"investigate":[33],"heritable":[34],"silencing.":[36],"In":[37,46],"the":[38,47,56,61,70,74,80,84,89,96,103,122,129,137,151,160,167,189,199,208,218,234,237,241],"mouse,":[39],"two":[40],"different":[41],"forms":[42],"of":[43,55,95,108,124,139,147,153,162,191,212,236,240],"XCI":[44,94,141,180,227],"occur.":[45],"preimplantation":[48],"embryo,":[49],"all":[50],"cells":[51,64],"undergo":[52],"imprinted":[53,93,110,140],"paternal":[57],"(Xp).":[59],"During":[60],"peri-implantation":[62],"period,":[63],"destined":[65],"give":[67],"rise":[68],"embryo":[71],"proper":[72],"erase":[73],"imprint":[75],"and":[76,111,177,210,220,228],"randomly":[77],"inactivate":[78],"either":[79],"maternal":[81],"or":[83],"Xp;":[85],"extraembryonic":[86],"cells,":[87],"on":[88,102,198],"other":[90],"hand,":[91],"maintain":[92,178],"Xp.":[97],"PRC2":[98,119,131,148],"enriched":[101,197],"inactive-X":[104],"during":[105],"early":[106,168],"stages":[107],"both":[109],"random":[112,179,192,213],"XCI.":[113,125,193,214],"It":[114],"is":[115],"therefore":[116],"that":[118,173],"contributes":[120],"initiation":[123,152,190,209],"Mouse":[126],"embryos":[127,175],"lacking":[128,182],"component":[132],"EED":[133,185],"harbor":[134],"defects":[135],"maintenance":[138,211],"differentiating":[143],"trophoblast":[144],"cells.":[145],"Assessment":[146],"requirement":[149],"XCI,":[154],"however,":[155],"has":[156],"been":[157],"hindered":[158],"presence":[161],"maternally":[163],"derived":[164],"embryo.":[169],"Here":[170],"we":[171],"show":[172],"Eed-/-":[174],"initiate":[176],"despite":[181,195],"any":[183],"functional":[184],"protein":[186],"prior":[187],"Thus,":[194],"being":[196],"inactive":[200,242],"X-chromosome,":[201],"PcGs":[202,225],"appear":[203],"be":[205],"dispensable":[206],"for":[207,224],"These":[215],"results":[216],"highlight":[217],"lineage-":[219],"differentiation":[221],"state-specific":[222],"requirements":[223],"argue":[229],"against":[230],"PcG":[231],"function":[232],"formation":[235],"facultative":[238],"heterochromatin":[239],"X-chromosome.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}