{"id":"https://openalex.org/W2092920261","doi":"https://doi.org/10.1097/00002480-200503000-00244","title":"EFFECTS OF ACIDOSIS ON FREE HEMOGLOBIN (Hb) CLEARANCE IN HEMODIALYZERS AND ITS IMPACT ON HUMAN CORONARY ARTERY ENDOTHELIAL CELLS (HCAEC)","display_name":"EFFECTS OF ACIDOSIS ON FREE HEMOGLOBIN (Hb) CLEARANCE IN HEMODIALYZERS AND ITS IMPACT ON HUMAN CORONARY ARTERY ENDOTHELIAL CELLS (HCAEC)","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W2092920261","doi":"https://doi.org/10.1097/00002480-200503000-00244","mag":"2092920261"},"language":"en","primary_location":{"id":"doi:10.1097/00002480-200503000-00244","doi":"https://doi.org/10.1097/00002480-200503000-00244","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002480-200503000-00244","pdf_url":null,"source":{"id":"https://openalex.org/S8999885","display_name":"ASAIO Journal","issn_l":"1058-2916","issn":["1058-2916","1538-943X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L H Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L H Nguyen","raw_affiliation_strings":["Surgery, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J C James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C James","raw_affiliation_strings":["Surgery, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029844807","display_name":"Jane M. Simoni","orcid":"https://orcid.org/0000-0002-8711-1576","observed_orcids":["https://orcid.org/0000-0002-8711-1576"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Simoni","raw_affiliation_strings":["Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX","Surgery, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]},{"raw_affiliation_string":"Surgery, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006220815","display_name":"John Griswold","orcid":"https://orcid.org/0000-0002-0578-0646","observed_orcids":["https://orcid.org/0000-0002-0578-0646"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Griswold","raw_affiliation_strings":["Surgery, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110136994","display_name":"Grace Simoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Simoni","raw_affiliation_strings":["Surgery, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J F Moeller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Moeller","raw_affiliation_strings":["Surgery, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006708563","display_name":"Chanwit Roongsritong","orcid":"https://orcid.org/0000-0003-3175-2697","observed_orcids":["https://orcid.org/0000-0003-3175-2697"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Roongsritong","raw_affiliation_strings":["Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Wesson","raw_affiliation_strings":["Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15458987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"2","first_page":"62A","last_page":"62A"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.18240000307559967,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0681999996304512,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hollow-fiber-dialyzer","display_name":"hollow fiber dialyzer","score":0.6600000262260437},{"id":"https://openalex.org/keywords/human-coronary-artery-endothelial-cells","display_name":"human coronary artery endothelial cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/endothelial-inflammation","display_name":"endothelial inflammation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/selectins","display_name":"selectins","score":0.625},{"id":"https://openalex.org/keywords/hemoglobin-autoxidation","display_name":"hemoglobin autoxidation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ferryl-hemoglobin","display_name":"ferryl hemoglobin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/albumin-clearance","display_name":"albumin clearance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6790000200271606},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6869285702705383},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5979619026184082},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5620598196983337},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.5198764801025391},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.44085830450057983},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4384186267852783},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.4332001209259033},{"id":"https://openalex.org/C2776635150","wikidata":"https://www.wikidata.org/wiki/Q13365776","display_name":"Uremia","level":2,"score":0.4283331036567688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3927015960216522},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3761257529258728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3459882438182831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25322261452674866},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.13249832391738892}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00002480-200503000-00244","doi":"https://doi.org/10.1097/00002480-200503000-00244","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002480-200503000-00244","pdf_url":null,"source":{"id":"https://openalex.org/S8999885","display_name":"ASAIO Journal","issn_l":"1058-2916","issn":["1058-2916","1538-943X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2805238647","https://openalex.org/W2191949855","https://openalex.org/W4412686482","https://openalex.org/W2753435151","https://openalex.org/W2038173243","https://openalex.org/W2125249200","https://openalex.org/W2419615638","https://openalex.org/W2770725964","https://openalex.org/W2300862639","https://openalex.org/W2752874905"],"abstract_inverted_index":{"Hemodialysis":[0],"(HD)":[1],"is":[2,73],"a":[3,77],"lifesaving":[4],"treatment.":[5],"Though,":[6],"this":[7],"therapy":[8],"cannot":[9],"correct":[10],"medical":[11],"conditions":[12],"associated":[13],"with":[14,29],"advanced":[15],"chronic":[16],"renal":[17],"failure.":[18],"Previous":[19],"studies":[20],"showed":[21],"that":[22,65,140],"oxidative":[23,169],"stress":[24],"in":[25,80,134,216],"HD":[26],"patients,":[27],"particularly":[28],"metabolic":[30],"acidosis,":[31],"increases":[32],"RBC":[33],"fragility.":[34],"Hb":[35,72,98,164,168,178,217],"after":[36],"exceeding":[37],"the":[38,41,122,135,161,187],"capacity":[39],"of":[40,52,55,88,97,118,137,147,163],"plasma":[42],"detoxifying":[43],"system":[44],"can":[45],"trigger":[46],"many":[47,67],"pathologic":[48],"reactions":[49],"like":[50],"removal":[51,96,136,162],"NO,":[53],"formation":[54],"reactive":[56],"oxygen":[57],"and":[58,61,69,103,115,171,180,185,219],"lipid":[59],"species,":[60,184],"redox":[62],"state":[63],"changes":[64],"induce":[66],"inflammatory":[68,110],"apoptotic":[70,116],"genes.":[71],"now":[74],"considered":[75],"as":[76],"progressive":[78],"factor":[79],"ESRD.":[81],"Hence,":[82],"we":[83,126],"studied":[84],"ex":[85],"vivo":[86],"effects":[87],"Altra":[89],"Flux":[90],"Cellulose":[91],"Diacetate":[92],"Hemodialyzer":[93],"(CHD)":[94],"on":[95],"under":[99],"acidic":[100,157,221],"(pH":[101,105],"6.8)":[102],"normal":[104],"7.4)":[106],"conditions.":[107],"By":[108],"monitoring":[109],"(ICAM-1,":[111],"VCAM-1,":[112],"P/E":[113],"Selectin)":[114],"responses":[117],"HCAEC":[119],"exposed":[120],"to":[121,152,182,225],"hollow":[123,191],"fiber":[124,192],"extracts,":[125],"also":[127],"tested":[128],"if":[129],"Hb/pH":[130],"may":[131],"be":[132,142],"involved":[133],"membranal":[138],"compounds":[139],"might":[141],"cytotoxic.":[143],"During":[144],"5":[145],"hours":[146],"HD,":[148],"CHD":[149,211],"was":[150],"unable":[151],"completely":[153],"clear":[154],"Hb.":[155],"The":[156,174,190],"pH":[158,176,197,204],"slightly":[159,200],"increased":[160,177,201],"but":[165],"it":[166],"triggered":[167],"degradation":[170],"albumin":[172],"clearance.":[173],"low":[175],"autoxidation":[179],"conversion":[181],"ferryl":[183],"destabilized":[186],"heme-globin":[188],"interface.":[189],"extracts":[193,199,206,222],"activated":[194],"HCAEC.":[195,226],"While":[196],"7.4":[198],"endothelial":[202],"inflammation,":[203],"6.8":[205],"induced":[207],"apoptosis.":[208],"In":[209],"summary,":[210],"were":[212],"only":[213],"partially":[214],"effective":[215],"clearance":[218],"their":[220],"appeared":[223],"toxic":[224]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
