{"id":"https://openalex.org/W2092919205","doi":"https://doi.org/10.4061/2011/407536","title":"The Importance of Mitochondrial DNA in Aging and Cancer","display_name":"The Importance of Mitochondrial DNA in Aging and Cancer","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2092919205","doi":"https://doi.org/10.4061/2011/407536","mag":"2092919205","pmid":"https://pubmed.ncbi.nlm.nih.gov/21584235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3092560"},"language":"en","primary_location":{"id":"doi:10.4061/2011/407536","doi":"https://doi.org/10.4061/2011/407536","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2011/407536","pdf_url":"https://downloads.hindawi.com/journals/jar/2011/407536.pdf","source":{"id":"https://openalex.org/S114231005","display_name":"Journal of Aging Research","issn_l":"2090-2204","issn":["2090-2204","2090-2212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Aging Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jar/2011/407536.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071554590","display_name":"Claus Desler","orcid":"https://orcid.org/0000-0002-0125-004X","observed_orcids":["https://orcid.org/0000-0002-0125-004X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus Desler","raw_affiliation_strings":["Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039258754","display_name":"Maiken Lise Marcker Espersen","orcid":"https://orcid.org/0000-0003-1042-7342","observed_orcids":["https://orcid.org/0000-0003-1042-7342"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maiken Lise Marcker","raw_affiliation_strings":["Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071647281","display_name":"Keshav Kumar Singh","orcid":"https://orcid.org/0000-0001-9028-4518","observed_orcids":["https://orcid.org/0000-0001-9028-4518","https://orcid.org/0009-0003-6510-4062"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keshav K. Singh","raw_affiliation_strings":["Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075856075","display_name":"Lene Juel Rasmussen","orcid":"https://orcid.org/0000-0001-6864-963X","observed_orcids":["https://orcid.org/0000-0001-6864-963X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Lene Juel Rasmussen","raw_affiliation_strings":["Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6864-963X","affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075856075"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":1000,"currency":"USD","value_usd":1000},"fwci":2.2469,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.88816016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2011","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.8510000109672546},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8050000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.7899200916290283},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7842180728912354},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5590497851371765},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5020344257354736},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4856047034263611},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4790288507938385},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4585876166820526},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4522344768047333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44957435131073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43004241585731506},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.42477360367774963},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.412193238735199},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39663243293762207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3862139582633972},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3774564266204834},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3442270755767822},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.29304933547973633},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2817814350128174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1910109519958496},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09691047668457031},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.4061/2011/407536","doi":"https://doi.org/10.4061/2011/407536","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2011/407536","pdf_url":"https://downloads.hindawi.com/journals/jar/2011/407536.pdf","source":{"id":"https://openalex.org/S114231005","display_name":"Journal of Aging Research","issn_l":"2090-2204","issn":["2090-2204","2090-2212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Aging Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3092560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3092560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Aging Res","raw_type":"Text"},{"id":"pmid:21584235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21584235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of aging research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.290.3746","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.290.3746","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/23/84/J_Aging_Res_2011_Mar_30_2011_407536.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:408c6a5bbbbc4a4097bb9d578477b326","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/408c6a5bbbbc4a4097bb9d578477b326","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging Research, Vol 2011 (2011)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/1cdcb7a0-cce9-4fa7-9ce5-f3785e154c89","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/1cdcb7a0-cce9-4fa7-9ce5-f3785e154c89","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Madsen, C D, Espersen, M L M, Singh, K K & Rasmussen, L J 2011, 'The importance of mitochondrial DNA in aging and cancer', Journal of Aging Research, vol. 2011, pp. 407536. https://doi.org/10.4061/2011/407536","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4061/2011/407536","doi":"https://doi.org/10.4061/2011/407536","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2011/407536","pdf_url":"https://downloads.hindawi.com/journals/jar/2011/407536.pdf","source":{"id":"https://openalex.org/S114231005","display_name":"Journal of Aging Research","issn_l":"2090-2204","issn":["2090-2204","2090-2212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Aging Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6891024971","display_name":"Mitochondria and Carcinogenesis","funder_award_id":"R01CA121904","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8449340949","display_name":null,"funder_award_id":"113655","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320322918","display_name":"Nordea-fonden","ror":"https://ror.org/03qadc961"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092919205.pdf","grobid_xml":"https://content.openalex.org/works/W2092919205.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W150054182","https://openalex.org/W1557712018","https://openalex.org/W1565810327","https://openalex.org/W1578283200","https://openalex.org/W1667711738","https://openalex.org/W1749022239","https://openalex.org/W1951314249","https://openalex.org/W1964717435","https://openalex.org/W1967830103","https://openalex.org/W1970345057","https://openalex.org/W1971104692","https://openalex.org/W1973851166","https://openalex.org/W1974396693","https://openalex.org/W1978900828","https://openalex.org/W1979505963","https://openalex.org/W1981932293","https://openalex.org/W1984780011","https://openalex.org/W1985135899","https://openalex.org/W1987219977","https://openalex.org/W1987379920","https://openalex.org/W1992930337","https://openalex.org/W1994527193","https://openalex.org/W1995829727","https://openalex.org/W1999218428","https://openalex.org/W2002973721","https://openalex.org/W2006096547","https://openalex.org/W2006561624","https://openalex.org/W2007491605","https://openalex.org/W2010730552","https://openalex.org/W2012770842","https://openalex.org/W2013647909","https://openalex.org/W2016486229","https://openalex.org/W2018185503","https://openalex.org/W2021491682","https://openalex.org/W2025548430","https://openalex.org/W2026525843","https://openalex.org/W2027322373","https://openalex.org/W2030261579","https://openalex.org/W2030363519","https://openalex.org/W2031646822","https://openalex.org/W2033559853","https://openalex.org/W2033832481","https://openalex.org/W2036988144","https://openalex.org/W2037771227","https://openalex.org/W2042734644","https://openalex.org/W2042793067","https://openalex.org/W2043895689","https://openalex.org/W2044480169","https://openalex.org/W2044494908","https://openalex.org/W2044525314","https://openalex.org/W2044897807","https://openalex.org/W2046910842","https://openalex.org/W2048487276","https://openalex.org/W2051810920","https://openalex.org/W2052703170","https://openalex.org/W2060930539","https://openalex.org/W2067302063","https://openalex.org/W2068337326","https://openalex.org/W2070852168","https://openalex.org/W2071869532","https://openalex.org/W2072451938","https://openalex.org/W2072969519","https://openalex.org/W2074303856","https://openalex.org/W2075006858","https://openalex.org/W2080859880","https://openalex.org/W2083326631","https://openalex.org/W2083671881","https://openalex.org/W2087023938","https://openalex.org/W2087379913","https://openalex.org/W2088655155","https://openalex.org/W2090021282","https://openalex.org/W2092078005","https://openalex.org/W2099286485","https://openalex.org/W2101861123","https://openalex.org/W2113279188","https://openalex.org/W2115359101","https://openalex.org/W2117517043","https://openalex.org/W2118984005","https://openalex.org/W2119660622","https://openalex.org/W2126474158","https://openalex.org/W2132965725","https://openalex.org/W2135792486","https://openalex.org/W2136543787","https://openalex.org/W2141663828","https://openalex.org/W2145795805","https://openalex.org/W2149835124","https://openalex.org/W2153029275","https://openalex.org/W2154812708","https://openalex.org/W2156182155","https://openalex.org/W2156241187","https://openalex.org/W2156612696","https://openalex.org/W2157512814","https://openalex.org/W2158615962","https://openalex.org/W2160785529","https://openalex.org/W2161877652","https://openalex.org/W2162107616","https://openalex.org/W2162674881","https://openalex.org/W2163069284","https://openalex.org/W2163360776","https://openalex.org/W2167044450","https://openalex.org/W2172305558","https://openalex.org/W2182589623","https://openalex.org/W2271180001","https://openalex.org/W2315512556","https://openalex.org/W2328643786","https://openalex.org/W4238119129","https://openalex.org/W4254119740","https://openalex.org/W4295935051"],"related_works":["https://openalex.org/W7095692703","https://openalex.org/W2983579966","https://openalex.org/W2064289777","https://openalex.org/W4285677036","https://openalex.org/W2049410972","https://openalex.org/W2991720968","https://openalex.org/W7039884645","https://openalex.org/W2405118491","https://openalex.org/W2783356125","https://openalex.org/W2780539753"],"abstract_inverted_index":{"Mitochondrial":[0],"dysfunction":[1],"has":[2],"been":[3],"implicated":[4],"in":[5,22],"premature":[6],"aging,":[7],"age-related":[8],"diseases,":[9],"and":[10,13,25,48,71,80],"tumor":[11],"initiation":[12,68],"progression.":[14],"Alterations":[15],"of":[16,33,38,46,58,63,69,78],"the":[17,39,44,64,76],"mitochondrial":[18,40,59],"genome":[19,41],"accumulate":[20],"both":[21],"aging":[23],"tissue":[24],"tumors.":[26],"This":[27],"paper":[28],"describes":[29],"our":[30],"contemporary":[31],"view":[32],"mechanisms":[34,53],"by":[35],"which":[36],"alterations":[37],"contributes":[42],"to":[43],"development":[45],"age-":[47],"tumor-related":[49],"pathological":[50],"conditions.":[51],"The":[52],"described":[54],"encompass":[55],"altered":[56,61],"production":[57,77],"ROS,":[60],"regulation":[62],"nuclear":[65],"epigenome,":[66],"affected":[67],"apoptosis,":[70],"a":[72],"limiting":[73],"effect":[74],"on":[75],"ribonucleotides":[79],"deoxyribonucleotides.":[81]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}