{"id":"https://openalex.org/W2092907397","doi":"https://doi.org/10.3109/00365513.2013.764572","title":"P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised","display_name":"P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised","publication_year":2013,"publication_date":"2013-02-19","ids":{"openalex":"https://openalex.org/W2092907397","doi":"https://doi.org/10.3109/00365513.2013.764572","mag":"2092907397","pmid":"https://pubmed.ncbi.nlm.nih.gov/23421771"},"language":"en","primary_location":{"id":"doi:10.3109/00365513.2013.764572","doi":"https://doi.org/10.3109/00365513.2013.764572","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365513.2013.764572","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072195521","display_name":"Petter J\u00e4remo","orcid":"https://orcid.org/0009-0007-3623-5812","observed_orcids":["https://orcid.org/0009-0007-3623-5812"]},"institutions":[{"id":"https://openalex.org/I4210149076","display_name":"Vrinnevisjukhuset i Norrk\u00f6ping","ror":"https://ror.org/03q82br40","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210149076"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Petter J\u00e4remo","raw_affiliation_strings":["Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden. petter.jaremo@beta.telenordia.se","Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden. petter.jaremo@beta.telenordia.se","institution_ids":["https://openalex.org/I4210149076"]},{"raw_affiliation_string":"Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210149076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077832898","display_name":"Micha Milovanovic","orcid":"https://orcid.org/0000-0001-5354-0164","observed_orcids":["https://orcid.org/0000-0001-5354-0164"]},"institutions":[{"id":"https://openalex.org/I4210149076","display_name":"Vrinnevisjukhuset i Norrk\u00f6ping","ror":"https://ror.org/03q82br40","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210149076"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Micha Milovanovic","raw_affiliation_strings":["Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210149076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059023883","display_name":"Caroline Buller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149076","display_name":"Vrinnevisjukhuset i Norrk\u00f6ping","ror":"https://ror.org/03q82br40","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210149076"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Caroline Buller","raw_affiliation_strings":["Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Vrinnevi Hospital, Norrk\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210149076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102851091","display_name":"Staffan Nilsson","orcid":"https://orcid.org/0000-0002-8628-8230","observed_orcids":["https://orcid.org/0000-0002-8628-8230"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Staffan Nilsson","raw_affiliation_strings":["Department of Medical and Health Sciences, Division of Community Medicine/General Practice, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Health Sciences, Division of Community Medicine/General Practice, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081283156","display_name":"Bengt G. Winblad","orcid":"https://orcid.org/0000-0002-0011-1179","observed_orcids":["https://orcid.org/0000-0002-0011-1179"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt Winblad","raw_affiliation_strings":["KI-Alzheimer's Disease Research Center, Karolinska Institute, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KI-Alzheimer's Disease Research Center, Karolinska Institute, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.684,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.81324842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"2","first_page":"170","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8539999723434448},{"id":"https://openalex.org/keywords/soluble-p-selectin","display_name":"soluble P-selectin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/platelet-reactivity","display_name":"platelet reactivity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/thrombin-receptor-activating-peptide","display_name":"thrombin receptor activating peptide","score":0.6790000200271606},{"id":"https://openalex.org/keywords/platelet-alpha-granules","display_name":"platelet alpha-granules","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C56701166","wikidata":"https://www.wikidata.org/wiki/Q4046137","display_name":"P-selectin","level":4,"score":0.796660840511322},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7607245445251465},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6630155444145203},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6584505438804626},{"id":"https://openalex.org/C2779835222","wikidata":"https://www.wikidata.org/wiki/Q4042403","display_name":"L-selectin","level":3,"score":0.5270954370498657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.503757655620575},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4921781122684479},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.470774382352829},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4511042833328247},{"id":"https://openalex.org/C110586980","wikidata":"https://www.wikidata.org/wiki/Q4168588","display_name":"Provocation test","level":3,"score":0.4405694007873535},{"id":"https://openalex.org/C155619193","wikidata":"https://www.wikidata.org/wiki/Q415915","display_name":"Selectin","level":3,"score":0.4270510971546173},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4021463096141815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37628376483917236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32009029388427734},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09778046607971191},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0970054566860199},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/00365513.2013.764572","doi":"https://doi.org/10.3109/00365513.2013.764572","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365513.2013.764572","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:23421771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23421771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of clinical and laboratory investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W254782515","https://openalex.org/W1536258113","https://openalex.org/W1607927168","https://openalex.org/W1985825991","https://openalex.org/W2017055415","https://openalex.org/W2022520974","https://openalex.org/W2057016253","https://openalex.org/W2075295221","https://openalex.org/W2079402113","https://openalex.org/W2080403157","https://openalex.org/W2086792633","https://openalex.org/W2087112240","https://openalex.org/W2135565955","https://openalex.org/W2163017683","https://openalex.org/W2165703295","https://openalex.org/W2171804302","https://openalex.org/W2407594696"],"related_works":["https://openalex.org/W2766354237","https://openalex.org/W1997721390","https://openalex.org/W2313901299","https://openalex.org/W2382415459","https://openalex.org/W2017236917","https://openalex.org/W2165703295","https://openalex.org/W2070783434","https://openalex.org/W2794615278","https://openalex.org/W4411539634","https://openalex.org/W2422339853"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Knowledge":[1],"concerning":[2],"the":[3,47,52,192,204],"neurobiological":[4],"importance":[5],"of":[6,237],"platelets":[7],"in":[8,23,29,62,110,134,183,191],"Alzheimer's":[9],"disease":[10,193,205],"(AD)":[11],"is":[12,16,26,35,49],"sparse.":[13],"P-selectin,":[14],"which":[15],"located":[17],"together":[18],"with":[19,152],"\u03b2-amyloid":[20],"precursor":[21],"proteins":[22],"platelet":[24,127,140,170,216],"\u03b1-granules,":[25],"also":[27],"found":[28],"endothelial":[30],"cells.":[31],"Upon":[32],"activation,":[33],"P-selectin":[34,60,82,131,142,155,181,188,196,226],"relocated":[36],"to":[37,54,94,214],"cell":[38],"surfaces":[39],"where":[40],"it":[41],"acts":[42],"as":[43,125,168,239],"a":[44,126,169],"receptor.":[45],"Subsequently,":[46],"protein":[48],"cleaved":[50],"from":[51,146],"membrane,":[53],"then":[55],"be":[56],"circulated.":[57],"We":[58,66],"investigated":[59],"behavior":[61],"AD":[63,72,135,148,211,232],"dementia.":[64],"METHODS:":[65],"recruited":[67],"23":[68],"persons":[69],"diagnosed":[70],"moderate":[71,184],"and":[73,89,108,206,228],"17":[74],"healthy":[75],"elders":[76],"without":[77,104,197],"obvious":[78],"memory":[79],"problems.":[80],"Circulating":[81],"was":[83,92,101,123,132,150,166,189,200,212],"analyzed":[84],"using":[85],"an":[86],"ELISA":[87],"technique":[88],"flow":[90],"cytometry":[91],"used":[93,124,167],"measure":[95,100],"surface-bound":[96,154],"P-selectin.":[97],"The":[98,218],"latter":[99],"carried":[102],"out":[103],"provocation":[105],"(platelet":[106,114],"activity)":[107],"after":[109,156],"vitro":[111],"agonist":[112,171,198],"stimulation":[113,199],"reactivity).":[115],"A":[116],"thrombin-receptor":[117],"activating":[118],"peptide":[119],"(TRAP-6)":[120],"(74":[121],"\u03bcmol/L))":[122],"agonist.":[128],"RESULTS:":[129],"Soluble":[130],"augmented":[133],"(p":[136,172],"=":[137,173],"0.019)":[138],"but":[139],"membrane-attached":[141,195],"did":[143],"not":[144],"differ":[145],"controls.":[147],"diagnosis":[149],"associated":[151],"less":[153],"provocation.":[157],"Significant":[158],"results":[159],"were":[160],"obtained":[161],"when":[162],"74":[163],"\u03bcmol/L":[164],"TRAP-6":[165],"0.0008).":[174],"CONCLUSION:":[175],"This":[176],"study":[177],"describes":[178],"apparently":[179],"paradoxical":[180],"reactions":[182],"AD.":[185],"While":[186],"soluble":[187],"higher":[190],"group,":[194],"no":[201],"different":[202],"between":[203],"control":[207],"groups.":[208],"In":[209],"contrast,":[210],"linked":[213],"lower":[215],"reactivity.":[217],"current":[219],"findings":[220],"encourage":[221],"further":[222],"research":[223],"into":[224],"this":[225],"paradox":[227],"its":[229],"relevance":[230],"for":[231],"and,":[233],"perhaps,":[234],"other":[235],"types":[236],"dementia":[238],"well.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}