{"id":"https://openalex.org/W2092873641","doi":"https://doi.org/10.1016/j.ejphar.2006.06.062","title":"Thromboxane A2 receptor-mediated G12/13-dependent glial morphological change","display_name":"Thromboxane A2 receptor-mediated G12/13-dependent glial morphological change","publication_year":2006,"publication_date":"2006-07-04","ids":{"openalex":"https://openalex.org/W2092873641","doi":"https://doi.org/10.1016/j.ejphar.2006.06.062","mag":"2092873641","pmid":"https://pubmed.ncbi.nlm.nih.gov/16876780"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2006.06.062","doi":"https://doi.org/10.1016/j.ejphar.2006.06.062","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2006.06.062","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111677553","display_name":"Shigeyoshi Honma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyoshi Honma","raw_affiliation_strings":["Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072089443","display_name":"Manami Saika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manami Saika","raw_affiliation_strings":["Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109135089","display_name":"Satoko Ohkubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Ohkubo","raw_affiliation_strings":["Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011925781","display_name":"Hitoshi Kurose","orcid":"https://orcid.org/0000-0003-4257-702X","observed_orcids":["https://orcid.org/0000-0003-4257-702X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Kurose","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109294034","display_name":"Norimichi Nakahata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Norimichi Nakahata","raw_affiliation_strings":["21st century COE program \u201cCRESCENDO\u201d, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan","Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"21st century COE program \u201cCRESCENDO\u201d, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109294034"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":1.3469,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.76053204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"545","issue":"2-3","first_page":"100","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboxane-a2-receptor","display_name":"thromboxane A2 receptor","score":1.0},{"id":"https://openalex.org/keywords/g12-13-signaling","display_name":"G12/13 signaling","score":0.8259999752044678},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.7940000295639038},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.824999988079071},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.953000009059906},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/u46619","display_name":"U46619","score":0.9160000085830688},{"id":"https://openalex.org/keywords/1321n1-cells","display_name":"1321N1 cells","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.8218749761581421},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.6868065595626831},{"id":"https://openalex.org/C201800478","wikidata":"https://www.wikidata.org/wiki/Q24721770","display_name":"Rho-associated protein kinase","level":3,"score":0.6124110817909241},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6076595187187195},{"id":"https://openalex.org/C2781099445","wikidata":"https://www.wikidata.org/wiki/Q4121060","display_name":"Stress fiber","level":4,"score":0.5759627819061279},{"id":"https://openalex.org/C51603380","wikidata":"https://www.wikidata.org/wiki/Q411978","display_name":"Thromboxane receptor","level":4,"score":0.5753561854362488},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4815285801887512},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.434814453125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4037114977836609},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3971588611602783},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39646539092063904},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3773390054702759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34792429208755493},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.2703428566455841},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1732766032218933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07079717516899109}],"mesh":[{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019796","descriptor_name":"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044365","descriptor_name":"GTP-Binding Protein alpha Subunits, G12-G13","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2006.06.062","doi":"https://doi.org/10.1016/j.ejphar.2006.06.062","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2006.06.062","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:16876780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16876780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1514082852","https://openalex.org/W1535712295","https://openalex.org/W1559865483","https://openalex.org/W1578779257","https://openalex.org/W1586575936","https://openalex.org/W1984132292","https://openalex.org/W1986226141","https://openalex.org/W1989683016","https://openalex.org/W1992319284","https://openalex.org/W1997182423","https://openalex.org/W1998414644","https://openalex.org/W1999466305","https://openalex.org/W2007660746","https://openalex.org/W2022282624","https://openalex.org/W2022723700","https://openalex.org/W2030009873","https://openalex.org/W2030625703","https://openalex.org/W2034839112","https://openalex.org/W2037669016","https://openalex.org/W2045649260","https://openalex.org/W2051162608","https://openalex.org/W2056358122","https://openalex.org/W2057170598","https://openalex.org/W2057927040","https://openalex.org/W2063461600","https://openalex.org/W2064826147","https://openalex.org/W2071537273","https://openalex.org/W2073382366","https://openalex.org/W2084786190","https://openalex.org/W2093820781","https://openalex.org/W2096791952","https://openalex.org/W2098372009","https://openalex.org/W2109354170","https://openalex.org/W2128635872","https://openalex.org/W2130892620","https://openalex.org/W2132630384","https://openalex.org/W2143442358","https://openalex.org/W2284859003","https://openalex.org/W2296415525","https://openalex.org/W2341388583","https://openalex.org/W2405283859","https://openalex.org/W2417002364","https://openalex.org/W6697410854","https://openalex.org/W6713498844","https://openalex.org/W6716925734"],"related_works":["https://openalex.org/W2050624653","https://openalex.org/W2064096454","https://openalex.org/W2093820781","https://openalex.org/W2084786190","https://openalex.org/W3101205293","https://openalex.org/W3106434249","https://openalex.org/W2405283859","https://openalex.org/W2098372009","https://openalex.org/W2073382366","https://openalex.org/W3100739619"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
