{"id":"https://openalex.org/W2092819722","doi":"https://doi.org/10.1097/00041433-199504000-00005","title":"Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer\u02bcs disease","display_name":"Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer\u02bcs disease","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W2092819722","doi":"https://doi.org/10.1097/00041433-199504000-00005","mag":"2092819722","pmid":"https://pubmed.ncbi.nlm.nih.gov/7773573"},"language":"en","primary_location":{"id":"doi:10.1097/00041433-199504000-00005","doi":"https://doi.org/10.1097/00041433-199504000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041433-199504000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036108557","display_name":"Robert W. Mahley","orcid":"https://orcid.org/0000-0003-3543-9278","observed_orcids":["https://orcid.org/0000-0003-3543-9278"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Mahley","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, Department of Pathology, University of California, San Francisco, USA","Department of Medicine, University of California, San Francisco, California, USA","Department of Pathology, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, Department of Pathology, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076984574","display_name":"Britto P. Nathan","orcid":"https://orcid.org/0000-0002-1968-4954","observed_orcids":["https://orcid.org/0000-0002-1968-4954"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britto P. Nathan","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051086671","display_name":"Stefano Bellosta","orcid":"https://orcid.org/0000-0001-5344-7824","observed_orcids":["https://orcid.org/0000-0001-5344-7824"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Bellosta","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063890834","display_name":"Robert E. Pitas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Pitas","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036108557"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":4.0575,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95363292,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"2","first_page":"86","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8889999985694885},{"id":"https://openalex.org/keywords/apolipoprotein-e3","display_name":"apolipoprotein E3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cytoskeletal-stability","display_name":"cytoskeletal stability","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9670000076293945},{"id":"https://openalex.org/keywords/neuronal-growth","display_name":"neuronal growth","score":0.7910000085830688},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/apoe-isoforms","display_name":"APOE isoforms","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.8224877119064331},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7647164463996887},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7066127061843872},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5992501974105835},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5636172294616699},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.44489967823028564},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44105812907218933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4143944978713989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3997306525707245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2912195920944214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22493726015090942},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1949809491634369},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1246393620967865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09967455267906189},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.08382755517959595}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00041433-199504000-00005","doi":"https://doi.org/10.1097/00041433-199504000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041433-199504000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},{"id":"pmid:7773573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7773573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in lipidology","raw_type":"Journal Article"},{"id":"pmh:oai:thekeep.eiu.edu:bio_fac-1544","doi":null,"is_oa":false,"landing_page_url":"https://works.bepress.com/britto_nathan/33/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196467","display_name":"The Keep (Eastern Illinois University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153871386","host_organization_name":"Eastern Illinois University","host_organization_lineage":["https://openalex.org/I153871386"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research & Creative Activity","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3786833126","display_name":"LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM","funder_award_id":"P01HL041633","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W67667528","https://openalex.org/W1967863634","https://openalex.org/W2158965128","https://openalex.org/W1997913988","https://openalex.org/W807960222","https://openalex.org/W1985570235","https://openalex.org/W1981302493","https://openalex.org/W202826278","https://openalex.org/W2039727377","https://openalex.org/W2047202269"],"abstract_inverted_index":{"Apolipoproteins":[0],"E3":[1,13],"and":[2,32],"E4":[3,19,41],"exert":[4],"differential":[5],"effects":[6,24],"on":[7],"neuronal":[8],"growth":[9],"in":[10],"vitro.":[11],"Apolipoprotein":[12],"supports":[14],"neurite":[15],"extension,":[16],"whereas":[17],"apolipoprotein":[18,40],"does":[20],"not.":[21],"These":[22],"isoform-specific":[23],"may":[25,33],"influence":[26],"the":[27,30,36,39,44],"stability":[28],"of":[29,38,46],"cytoskeleton":[31],"account":[34],"for":[35],"association":[37],"isoform":[42],"with":[43],"pathogenesis":[45],"Alzheimer's":[47],"disease.":[48]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}