{"id":"https://openalex.org/W2092796629","doi":"https://doi.org/10.1016/j.jamcollsurg.2008.06.064","title":"The NOD2 agonist muramyl-di-peptide (MDP) reverses the inhibitory effects of TLR4 activation on enterocyte proliferation through effects on beta-catenin signaling, and attenuates the severity of experimental necrotizing enterocolitis","display_name":"The NOD2 agonist muramyl-di-peptide (MDP) reverses the inhibitory effects of TLR4 activation on enterocyte proliferation through effects on beta-catenin signaling, and attenuates the severity of experimental necrotizing enterocolitis","publication_year":2008,"publication_date":"2008-08-28","ids":{"openalex":"https://openalex.org/W2092796629","doi":"https://doi.org/10.1016/j.jamcollsurg.2008.06.064","mag":"2092796629"},"language":"en","primary_location":{"id":"doi:10.1016/j.jamcollsurg.2008.06.064","doi":"https://doi.org/10.1016/j.jamcollsurg.2008.06.064","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2008.06.064","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109075013","display_name":"Ward M. Richardson","orcid":"https://orcid.org/0009-0006-2408-7974","observed_orcids":["https://orcid.org/0009-0006-2408-7974"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ward M. Richardson","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao-Hua Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Hua Shi","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083663740","display_name":"Steven C. Gribar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Gribar","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111704621","display_name":"Maria F. Branca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Branca","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070525145","display_name":"Theresa D. Dubowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Dubowski","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362092","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-3519-8638","observed_orcids":["https://orcid.org/0000-0003-3519-8638"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084085850","display_name":"Chhindler Sodhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chhindler Sodhi","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083298871","display_name":"David Joel Hackam","orcid":"https://orcid.org/0000-0001-5195-8807","observed_orcids":["https://orcid.org/0000-0001-5195-8807"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Hackam","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18541692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"207","issue":"3","first_page":"S34","last_page":"S34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muramyl-dipeptide","display_name":"muramyl dipeptide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8600000143051147},{"id":"https://openalex.org/keywords/enterocyte-proliferation","display_name":"enterocyte proliferation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.531000018119812},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9028475284576416},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.7777137756347656},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6598342657089233},{"id":"https://openalex.org/C2779604457","wikidata":"https://www.wikidata.org/wiki/Q1340349","display_name":"Enterocyte","level":3,"score":0.6367449760437012},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4848714768886566},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4505888521671295},{"id":"https://openalex.org/C7573103","wikidata":"https://www.wikidata.org/wiki/Q416481","display_name":"NOD2","level":4,"score":0.42710593342781067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35832127928733826},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.324268639087677},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20202180743217468},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.0},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jamcollsurg.2008.06.064","doi":"https://doi.org/10.1016/j.jamcollsurg.2008.06.064","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2008.06.064","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032343036","https://openalex.org/W2133462434","https://openalex.org/W4308005194","https://openalex.org/W2148134626","https://openalex.org/W1996595944","https://openalex.org/W7128781225","https://openalex.org/W3031828905","https://openalex.org/W2109601788","https://openalex.org/W2991637840","https://openalex.org/W318889839"],"abstract_inverted_index":{"Richardson,":[0],"Ward":[1],"M.":[2],"MD;":[3,10],"Shi,":[4],"Xiao-Hua":[5],"PhD;":[6,21],"Gribar,":[7],"Steven":[8],"C.":[9],"Branca,":[11],"Maria":[12],"BA;":[13,16],"Dubowski,":[14],"Theresa":[15],"Li,":[17],"Jun;":[18],"Sodhi,":[19],"Chhindler":[20],"Hackam,":[22],"David":[23],"J.":[24],"MD,":[25],"PhD,":[26],"FACS":[27],"Author":[28],"Information":[29]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}