{"id":"https://openalex.org/W2092769914","doi":"https://doi.org/10.1073/pnas.82.22.7535","title":"A human histone H4 gene exhibits cell cycle-dependent changes in chromatin structure that correlate with its expression.","display_name":"A human histone H4 gene exhibits cell cycle-dependent changes in chromatin structure that correlate with its expression.","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W2092769914","doi":"https://doi.org/10.1073/pnas.82.22.7535","mag":"2092769914","pmid":"https://pubmed.ncbi.nlm.nih.gov/2999768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/390851"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.22.7535","doi":"https://doi.org/10.1073/pnas.82.22.7535","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.22.7535","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390851","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011200436","display_name":"Susan A. Chrysogelos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Chrysogelos","raw_affiliation_strings":["University of Florida, College of Medicine, Gainesville, FL 32610;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, College of Medicine, Gainesville, FL 32610;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113652101","display_name":"Donald E. Riley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Riley","raw_affiliation_strings":["tDepartments of Genetics and Medicine and the Center for Inherited Disease, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"tDepartments of Genetics and Medicine and the Center for Inherited Disease, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110166645","display_name":"Gary Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Stein","raw_affiliation_strings":["University of Florida, College of Medicine, Gainesville, FL 32610;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, College of Medicine, Gainesville, FL 32610;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Stein","raw_affiliation_strings":["University of Florida, College of Medicine, Gainesville, FL 32610;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, College of Medicine, Gainesville, FL 32610;","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6692,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.84734985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"82","issue":"22","first_page":"7535","last_page":"7539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-h4-gene","display_name":"histone H4 gene","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.7990000247955322},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.49300000071525574},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.7540000081062317},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dnase-i-sensitivity","display_name":"DNase I sensitivity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hela-s3-cells","display_name":"HeLa S3 cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/beta-globin-gene","display_name":"beta-globin gene","score":0.9779999852180481},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/histone-genes","display_name":"histone genes","score":0.625}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7266584634780884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7105200290679932},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5828126668930054},{"id":"https://openalex.org/C182614070","wikidata":"https://www.wikidata.org/wiki/Q17119065","display_name":"DNase I hypersensitive site","level":5,"score":0.5568225383758545},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5543583035469055},{"id":"https://openalex.org/C2779085176","wikidata":"https://www.wikidata.org/wiki/Q24721644","display_name":"Histone H4","level":4,"score":0.5375269651412964},{"id":"https://openalex.org/C139024627","wikidata":"https://www.wikidata.org/wiki/Q4293132","display_name":"Micrococcal nuclease","level":5,"score":0.5035666823387146},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.47363796830177307},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.458257794380188},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4428282678127289},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4234570860862732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42179882526397705},{"id":"https://openalex.org/C2779377703","wikidata":"https://www.wikidata.org/wiki/Q14901483","display_name":"Deoxyribonuclease I","level":4,"score":0.4182102680206299},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3923286497592926},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.3233475685119629},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3014393448829651},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.21942374110221863},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015719","descriptor_name":"Single-Strand Specific DNA and RNA Endonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.82.22.7535","doi":"https://doi.org/10.1073/pnas.82.22.7535","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.22.7535","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:390851","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390851","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2999768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2999768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:390851","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390851","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G383666782","display_name":"Identification of Histone Gene Regulatory Sequences","funder_award_id":"R01GM032010","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5472194658","display_name":"Proteins of Blood Coagulation","funder_award_id":"R01HL016919","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000910310","display_name":"Basic Microbiology and Infectious Disease","funder_award_id":"T32AI007110","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W783728065","https://openalex.org/W1131804799","https://openalex.org/W1515029606","https://openalex.org/W1527799443","https://openalex.org/W1922007066","https://openalex.org/W1980018308","https://openalex.org/W1980065496","https://openalex.org/W1982026809","https://openalex.org/W1983969012","https://openalex.org/W1987904181","https://openalex.org/W1998231415","https://openalex.org/W2004811497","https://openalex.org/W2009115308","https://openalex.org/W2009764033","https://openalex.org/W2014038211","https://openalex.org/W2017588515","https://openalex.org/W2027630830","https://openalex.org/W2033231327","https://openalex.org/W2037285029","https://openalex.org/W2039416580","https://openalex.org/W2041383836","https://openalex.org/W2042491847","https://openalex.org/W2042543706","https://openalex.org/W2046399641","https://openalex.org/W2047122757","https://openalex.org/W2048817297","https://openalex.org/W2049635421","https://openalex.org/W2051139385","https://openalex.org/W2057279985","https://openalex.org/W2057381572","https://openalex.org/W2063248559","https://openalex.org/W2063450941","https://openalex.org/W2069283208","https://openalex.org/W2069711301","https://openalex.org/W2070558501","https://openalex.org/W2070907662","https://openalex.org/W2073446257","https://openalex.org/W2075956107","https://openalex.org/W2078623603","https://openalex.org/W2080086131","https://openalex.org/W2085064863","https://openalex.org/W2094811739","https://openalex.org/W2159827892","https://openalex.org/W2167110107","https://openalex.org/W2395310454","https://openalex.org/W4235025410","https://openalex.org/W4237468955","https://openalex.org/W4245081854"],"related_works":["https://openalex.org/W1505430080","https://openalex.org/W2062228343","https://openalex.org/W2092619716","https://openalex.org/W2214889449","https://openalex.org/W2027545290","https://openalex.org/W1975146019","https://openalex.org/W2063651211","https://openalex.org/W1964373095","https://openalex.org/W2086892723","https://openalex.org/W1766883331"],"abstract_inverted_index":{"By":[0],"use":[1],"of":[2,24,28,43,68,73,97,127,167,191,212],"synchronized":[3],"human":[4,99],"HeLa":[5,107],"S3":[6],"cells,":[7,108],"a":[8,29,40,121,125,199,210],"site":[9,36,64],"sensitive":[10,50],"to":[11,38,46,51,61,158,161],"both":[12],"DNase":[13,52,128],"I":[14,53,129],"and":[15,57,88,116,165,216],"nuclease":[16,74,131,140],"S1":[17,75,132],"was":[18,77,109,120],"identified":[19],"50-150":[20],"base":[21,48],"pairs":[22,49],"upstream":[23],"the":[25,62,66,84,98,113,147,162,194,213],"ATG":[26],"codon":[27],"cell":[30,114,148,214],"cycle-dependent":[31,149],"histone":[32,154,179],"H4":[33,155],"gene.":[34],"This":[35],"expanded":[37],"include":[39],"broad":[41],"region":[42],"approximately":[44],"equal":[45],"300":[47],"throughout":[54,112],"S":[55,81],"phase":[56],"then":[58],"narrowed":[59],"again":[60],"original":[63],"after":[65],"completion":[67],"DNA":[69],"replication.":[70,145,174],"The":[71,94],"level":[72,190],"sensitivity":[76,141],"greatest":[78],"during":[79],"early":[80],"phase,":[82],"when":[83],"gene":[85,156,169,195],"is":[86,92,103,196],"replicated":[87],"its":[89,144,173],"transcription":[90],"rate":[91],"maximal.":[93],"chromatin":[95,150,206],"structure":[96,207],"beta-globin":[100],"gene,":[101],"which":[102],"not":[104],"expressed":[105],"in":[106,117,139,152,198,205],"also":[110],"analyzed":[111],"cycle,":[115],"no":[118],"case":[119],"sub-band":[122],"seen":[123],"as":[124,181,209],"result":[126],"or":[130],"digestion,":[133],"nor":[134],"were":[135],"there":[136],"any":[137],"changes":[138,204],"correlated":[142],"with":[143,183],"Thus":[146],"alterations":[151],"this":[153,168],"appear":[157],"be":[159],"due":[160],"coupled":[163],"replication":[164],"expression":[166],"rather":[170],"than":[171],"simply":[172],"These":[175],"results":[176],"suggest":[177],"that":[178],"genes,":[180,186],"compared":[182],"developmentally":[184],"regulated":[185],"exhibit":[187],"an":[188],"\"intermediate\"":[189],"regulation":[192],"whereby":[193],"never":[197],"completely":[200],"inactive":[201],"conformation,":[202],"but":[203],"occur":[208],"function":[211],"cycle":[215],"expression.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}