{"id":"https://openalex.org/W2092767166","doi":"https://doi.org/10.1039/c1an15070g","title":"Aptasensor based on the selective electrodeposition of protein-linked gold nanoparticles on screen-printed electrodes","display_name":"Aptasensor based on the selective electrodeposition of protein-linked gold nanoparticles on screen-printed electrodes","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2092767166","doi":"https://doi.org/10.1039/c1an15070g","mag":"2092767166","pmid":"https://pubmed.ncbi.nlm.nih.gov/21394378"},"language":"en","primary_location":{"id":"doi:10.1039/c1an15070g","doi":"https://doi.org/10.1039/c1an15070g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c1an15070g","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047948559","display_name":"Miguel Moreno","orcid":"https://orcid.org/0000-0002-6065-4095","observed_orcids":["https://orcid.org/0000-0002-6065-4095"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Moreno","raw_affiliation_strings":["Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1, 28871, Alcal\u00e1 de Henares, Madrid, Spain. morenomm@cab.inta-csic.es","Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1,Alcal\u00e1 de Henares, Madrid,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1, 28871, Alcal\u00e1 de Henares, Madrid, Spain. morenomm@cab.inta-csic.es","institution_ids":["https://openalex.org/I189268942"]},{"raw_affiliation_string":"Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1,Alcal\u00e1 de Henares, Madrid,Spain","institution_ids":["https://openalex.org/I189268942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019058082","display_name":"V\u0131\u0301ctor M. Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-7538-0552","observed_orcids":["https://orcid.org/0000-0001-7538-0552"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V. M. Gonz\u00e1lez","raw_affiliation_strings":["Departamento de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal (IRYCIS), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica-Investigaci\u00f3n, Hospital Ram\u00f3n y Cajal (IRYCIS), Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057218922","display_name":"Esther Rinc\u00f3n","orcid":"https://orcid.org/0000-0001-6086-6154","observed_orcids":["https://orcid.org/0000-0001-6086-6154"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Rinc\u00f3n","raw_affiliation_strings":["Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084018746","display_name":"Alberto Domingo","orcid":"https://orcid.org/0000-0002-4332-7033","observed_orcids":["https://orcid.org/0000-0002-4332-7033"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Domingo","raw_affiliation_strings":["Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072050580","display_name":"Elena Dom\u0131\u0301nguez","orcid":"https://orcid.org/0000-0002-7681-2043","observed_orcids":["https://orcid.org/0000-0002-7681-2043"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Dom\u00ednguez","raw_affiliation_strings":["Departamento Qu\u00edmica Anal\u00edtica e Ingenier\u00eda Qu\u00edmica, Facultad de Farmacia, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento Qu\u00edmica Anal\u00edtica e Ingenier\u00eda Qu\u00edmica, Facultad de Farmacia, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047948559"],"corresponding_institution_ids":["https://openalex.org/I189268942"],"apc_list":null,"apc_paid":null,"fwci":1.4269,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.80474252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"136","issue":"9","first_page":"1810","last_page":"1810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptasensor","display_name":"aptasensor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.9660000205039978},{"id":"https://openalex.org/keywords/screen-printed-electrodes","display_name":"screen-printed electrodes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/leishmania-infantum","display_name":"Leishmania infantum","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.724284827709198},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.63507479429245},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5424928665161133},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5022356510162354},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.43531233072280884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4074920415878296},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004595","descriptor_name":"Electroplating","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018314","descriptor_name":"Leishmania infantum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/c1an15070g","doi":"https://doi.org/10.1039/c1an15070g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c1an15070g","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},{"id":"pmid:21394378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21394378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1968188298","https://openalex.org/W1979013297","https://openalex.org/W1989214699","https://openalex.org/W1989358260","https://openalex.org/W1990943922","https://openalex.org/W1993603706","https://openalex.org/W1997708087","https://openalex.org/W1999235724","https://openalex.org/W2037318709","https://openalex.org/W2045012155","https://openalex.org/W2046890061","https://openalex.org/W2052826004","https://openalex.org/W2080494749","https://openalex.org/W2081987589","https://openalex.org/W2089625500","https://openalex.org/W2090899265","https://openalex.org/W2090971706","https://openalex.org/W2094042044","https://openalex.org/W2095676657","https://openalex.org/W2102947851","https://openalex.org/W2130356816","https://openalex.org/W2139417210","https://openalex.org/W2156423980","https://openalex.org/W2168578188","https://openalex.org/W2170679909"],"related_works":["https://openalex.org/W2042874885","https://openalex.org/W2030891577","https://openalex.org/W2771196074","https://openalex.org/W1979516502","https://openalex.org/W1980720606","https://openalex.org/W2809876529","https://openalex.org/W2931184735","https://openalex.org/W2401330026","https://openalex.org/W1997708087","https://openalex.org/W1606359331"],"abstract_inverted_index":{"The":[0,60],"electrodeposition":[1,18,39,61,114],"of":[2,19,30,40,69,77,86,93,112,115,125,131],"DNA-gold":[3],"nanoparticles":[4,45,58],"previously":[5],"developed":[6],"in":[7,51,95,141],"our":[8],"group":[9],"has":[10],"been":[11],"used":[12,90],"as":[13],"starting":[14],"point":[15],"for":[16],"the":[17,38,75,78,110,113,123,126,129],"proteins":[20,41,116,140],"attached":[21],"to":[22,43,99,118],"gold":[23,44,48,57,119],"nanoparticles.":[24],"We":[25],"have":[26,106],"performed":[27],"a":[28,34,52,65,133,142],"proof":[29,92],"principle":[31],"by":[32,83],"developing":[33,132],"methodology":[35],"based":[36],"on":[37,46],"bound":[42,117],"screen-printed":[47],"microelectrodes":[49],"using,":[50],"first":[53],"approach,":[54],"horseradish":[55],"peroxide-conjugated":[56],"(gold-HRP).":[59],"was":[62,81],"achieved":[63],"at":[64],"current":[66],"positive":[67],"potential":[68],"800":[70],"mV":[71],"vs.":[72],"Ag/AgCl":[73],"and":[74],"functionality":[76,111],"electrodeposited":[79],"HRP-particles":[80],"tested":[82],"electrochemical":[84],"reduction":[85],"H(2)O(2).":[87],"Furthermore,":[88],"we":[89,105],"this":[91],"concept":[94],"an":[96],"aptasensor":[97],"application":[98],"detect":[100],"Leishmania":[101],"infantum":[102],"KMP-11.":[103],"Hence,":[104],"demonstrated":[107],"not":[108],"only":[109],"nanoparticles,":[120],"but":[121],"also":[122],"utility":[124],"method":[127],"with":[128],"aim":[130],"real":[134],"biosensor":[135],"containing":[136],"multiple":[137],"enzymes":[138],"or":[139],"multimodular":[143],"device.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}