{"id":"https://openalex.org/W2092741237","doi":"https://doi.org/10.1186/1471-2407-11-259","title":"Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival","display_name":"Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival","publication_year":2011,"publication_date":"2011-06-21","ids":{"openalex":"https://openalex.org/W2092741237","doi":"https://doi.org/10.1186/1471-2407-11-259","mag":"2092741237","pmid":"https://pubmed.ncbi.nlm.nih.gov/21689459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3134426"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-11-259","doi":"https://doi.org/10.1186/1471-2407-11-259","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-11-259","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-259","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-259","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082889084","display_name":"Sara Huerta\u2010Y\u00e9pez","orcid":"https://orcid.org/0000-0001-5633-6249","observed_orcids":["https://orcid.org/0000-0001-5633-6249"]},"institutions":[{"id":"https://openalex.org/I4210097267","display_name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","ror":"https://ror.org/00nzavp26","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210097267"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Sara Huerta-Yepez","raw_affiliation_strings":["Unidad de Investigacion en Enferemedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, SSa, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigacion en Enferemedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, SSa, Mexico","institution_ids":["https://openalex.org/I4210097267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110104644","display_name":"Nam K. Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nam K Yoon","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091584908","display_name":"Angeles Hernandez-Cueto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097267","display_name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","ror":"https://ror.org/00nzavp26","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210097267"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Angeles Hernandez-Cueto","raw_affiliation_strings":["Unidad de Investigacion en Enferemedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, SSa, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigacion en Enferemedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, SSa, Mexico","institution_ids":["https://openalex.org/I4210097267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047456713","display_name":"Vei H. Mah","orcid":"https://orcid.org/0000-0003-0186-7805","observed_orcids":["https://orcid.org/0000-0003-0186-7805"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vei Mah","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068075065","display_name":"Clara M. Rivera-Pazos","orcid":"https://orcid.org/0000-0002-7983-968X","observed_orcids":["https://orcid.org/0000-0002-7983-968X"]},"institutions":[{"id":"https://openalex.org/I4210097267","display_name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","ror":"https://ror.org/00nzavp26","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210097267"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Clara M Rivera-Pazos","raw_affiliation_strings":["Unidad de Investigacion en Enferemedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, SSa, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigacion en Enferemedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, SSa, Mexico","institution_ids":["https://openalex.org/I4210097267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108608167","display_name":"Devasis Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devasis Chatterjee","raw_affiliation_strings":["Department of Medicine, Rhode Island Hospital; and The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA","Department of Medicine, Rhode Island Hospital","The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rhode Island Hospital; and The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Medicine, Rhode Island Hospital","institution_ids":["https://openalex.org/I2800446032"]},{"raw_affiliation_string":"The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067305483","display_name":"Mario I. Vega","orcid":"https://orcid.org/0000-0002-3932-2483","observed_orcids":["https://orcid.org/0000-0002-3932-2483"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mario I Vega","raw_affiliation_strings":["Unidad de Investigacion Medica en Inmunologia e Infectologia, CMN, IMSS, La Raza, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigacion Medica en Inmunologia e Infectologia, CMN, IMSS, La Raza, Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084486790","display_name":"Erin L. Maresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin L Maresh","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000192581","display_name":"Steve Horvath","orcid":"https://orcid.org/0000-0002-4110-3589","observed_orcids":["https://orcid.org/0000-0002-4110-3589"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Horvath","raw_affiliation_strings":["Department of Biostatistics, Department of Human Genetics, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Department of Human Genetics, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050051156","display_name":"David Chia","orcid":"https://orcid.org/0000-0002-0723-3670","observed_orcids":["https://orcid.org/0000-0002-0723-3670"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Chia","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055490703","display_name":"Benjamin Bonavida","orcid":"https://orcid.org/0000-0001-5594-2060","observed_orcids":["https://orcid.org/0000-0001-5594-2060"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Benjamin Bonavida","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006079178","display_name":"Lee Goodglick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee Goodglick","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006079178","https://openalex.org/A5055490703"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.2073,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.8820709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"259","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rkip","display_name":"RKIP","score":0.75},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8320000171661377},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.746999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8125601410865784},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6604282259941101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6361052393913269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5949151515960693},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5377040505409241},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4952453672885895},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4927707016468048},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4650517702102661},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.4606705904006958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44885703921318054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20449188351631165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17330336570739746},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15520617365837097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1368555724620819}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049488","descriptor_name":"Phosphatidylethanolamine Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049488","descriptor_name":"Phosphatidylethanolamine Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049488","descriptor_name":"Phosphatidylethanolamine Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2407-11-259","doi":"https://doi.org/10.1186/1471-2407-11-259","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-11-259","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-259","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3134426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3134426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:21689459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21689459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ca85d02a9d8645949bafc743ba174023","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ca85d02a9d8645949bafc743ba174023","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 11, Iss 1, p 259 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt45n0h8j2","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/45n0h8j2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, vol 11, iss 1","raw_type":"article"},{"id":"pmh:qt45n0h8j2","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/45n0h8j2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Huerta-Yepez, Sara; Yoon, Nam K; Hernandez-Cueto, Angeles; Mah, Vei; Rivera-Pazos, Clara M; Chatterjee, Devasis; \u00c2\u00a0et al.(2011). Expression of Phosphorylated Raf Kinase Inhibitor Protein (pRKIP) is a Predictor of Lung Cancer Survival. BMC Cancer, 11(1), 259. doi: http://dx.doi.org/10.1186/1471-2407-11-259. Retrieved from: http://www.escholarship.org/uc/item/45n0h8j2","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-11-259","doi":"https://doi.org/10.1186/1471-2407-11-259","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-11-259","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-259","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1611099181","display_name":null,"funder_award_id":"P50CA90388","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1781393783","display_name":"COBRE Center for Cancer Research Development","funder_award_id":"P20RR017695","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2497671199","display_name":null,"funder_award_id":"CA86366","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3609496582","display_name":"The Early Detection Research Network Biomarker Resource Laboratory at UCLA","funder_award_id":"U24CA086366","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G377903287","display_name":null,"funder_award_id":"P20 RR-17695","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4344410982","display_name":"UCLA SPORE IN LUNG CANCER","funder_award_id":"P50CA090388","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000299964","display_name":null,"funder_award_id":"CA-86366","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092741237.pdf","grobid_xml":"https://content.openalex.org/works/W2092741237.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1966453709","https://openalex.org/W1967438883","https://openalex.org/W1971303929","https://openalex.org/W1975403276","https://openalex.org/W1986408860","https://openalex.org/W1993338076","https://openalex.org/W2018168645","https://openalex.org/W2019045124","https://openalex.org/W2025647419","https://openalex.org/W2030063660","https://openalex.org/W2040911711","https://openalex.org/W2045951374","https://openalex.org/W2046286252","https://openalex.org/W2063139884","https://openalex.org/W2068033067","https://openalex.org/W2089185822","https://openalex.org/W2094664006","https://openalex.org/W2098795508","https://openalex.org/W2106435751","https://openalex.org/W2107108391","https://openalex.org/W2111217479","https://openalex.org/W2118411892","https://openalex.org/W2122931235","https://openalex.org/W2125305744","https://openalex.org/W2126934083","https://openalex.org/W2131605616","https://openalex.org/W2135803007","https://openalex.org/W2136222819","https://openalex.org/W2136627244","https://openalex.org/W2136877606","https://openalex.org/W2142242441","https://openalex.org/W2142308379","https://openalex.org/W2163542553","https://openalex.org/W2164363164","https://openalex.org/W2167451931","https://openalex.org/W2167689405","https://openalex.org/W4242406743","https://openalex.org/W4293245634"],"related_works":["https://openalex.org/W2020294390","https://openalex.org/W2155770085","https://openalex.org/W2267889272","https://openalex.org/W3004982130","https://openalex.org/W3166913909","https://openalex.org/W2378464726","https://openalex.org/W2321200189","https://openalex.org/W1991353287","https://openalex.org/W3005265713","https://openalex.org/W2265315535"],"abstract_inverted_index":{"BACKGROUND:":[0],"Raf-1":[1],"kinase":[2,31],"inhibitor":[3],"protein":[4,30],"(RKIP)":[5],"has":[6,63,72],"been":[7,65],"reported":[8],"to":[9,35,129,149],"negatively":[10],"regulate":[11],"signal":[12],"kinases":[13],"of":[14,37,53,58,77,87,125,141,183,199],"major":[15],"survival":[16,147],"pathways.":[17],"RKIP":[18,38,41,69,89,102,184],"activity":[19],"is":[20,43],"modulated":[21],"in":[22,45,92,109,118,127,160,165,187],"part":[23],"by":[24,29],"phosphorylation":[25],"on":[26,67],"Serine":[27],"153":[28],"C,":[32],"which":[33],"leads":[34],"dissociation":[36],"from":[39],"Raf-1.":[40],"expression":[42,70,85,105,123,140,181],"low":[44],"many":[46],"human":[47,93],"cancers":[48],"and":[49,71,90,103,111,164,185],"represents":[50],"an":[51],"indicator":[52,198],"poor":[54],"prognosis":[55],"and/or":[56],"induction":[57],"metastasis.":[59],"The":[60,80],"prognostic":[61],"power":[62,135],"typically":[64],"based":[66],"total":[68,130],"not":[73],"considered":[74],"the":[75,84,122,177,180],"significance":[76],"phospho-RKIP.":[78],"METHODS:":[79],"present":[81],"study":[82,174],"examined":[83],"levels":[86,106,115,124,151],"both":[88],"phospho-RKIP":[91,104,114,142,186,194],"lung":[94,170,188],"cancer":[95],"tissue":[96],"microarray":[97],"proteomics":[98],"technology.":[99],"RESULTS:":[100],"Total":[101],"were":[107],"similar":[108],"normal":[110,139],"cancerous":[112],"tissues.":[113],"slightly":[116],"decreased":[117],"metastatic":[119],"lesions.":[120],"However,":[121],"phospho-RKIP,":[126],"contrast":[128],"RKIP,":[131],"displayed":[132],"significant":[133],"predictive":[134,197],"for":[136,176],"outcome":[137],"with":[138,167],"predicting":[143],"a":[144,196],"more":[145,158,161],"favorable":[146],"compared":[148],"lower":[150],"(P":[152],"=":[153],"0.0118);":[154],"this":[155],"was":[156,195],"even":[157],"pronounced":[159],"senior":[162],"individuals":[163],"those":[166],"early":[168],"stage":[169],"cancer.":[171,189],"CONCLUSIONS:":[172],"This":[173],"examines":[175],"first":[178],"time,":[179],"profile":[182],"Significantly,":[190],"we":[191],"found":[192],"that":[193],"survival.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
