{"id":"https://openalex.org/W2092735317","doi":"https://doi.org/10.1002/glia.10225","title":"Expression of S\u2010100 protein is related to neuronal damage in MPTP\u2010treated mice","display_name":"Expression of S\u2010100 protein is related to neuronal damage in MPTP\u2010treated mice","publication_year":2003,"publication_date":"2003-03-25","ids":{"openalex":"https://openalex.org/W2092735317","doi":"https://doi.org/10.1002/glia.10225","mag":"2092735317","pmid":"https://pubmed.ncbi.nlm.nih.gov/12673835"},"language":"en","primary_location":{"id":"doi:10.1002/glia.10225","doi":"https://doi.org/10.1002/glia.10225","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.10225","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109129818","display_name":"Yasuko Muramatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuko Muramatsu","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048311351","display_name":"R. Kurosaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rumiko Kurosaki","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020382696","display_name":"Hijiri Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hijiri Watanabe","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058432272","display_name":"Mari Michimata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari Michimata","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000285722","display_name":"Mitsunobu Matsubara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsunobu Matsubara","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008308259","display_name":"Yutaka Imai","orcid":"https://orcid.org/0000-0003-3925-8837","observed_orcids":["https://orcid.org/0000-0003-3925-8837"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Imai","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science, and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059583115","display_name":"Tsutomu Araki","orcid":"https://orcid.org/0000-0001-5943-1145","observed_orcids":["https://orcid.org/0000-0001-5943-1145"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsutomu Araki","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059583115"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":4.6187,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.9480427,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"3","first_page":"307","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.35499998927116394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.925000011920929},{"id":"https://openalex.org/keywords/s100beta","display_name":"S100\u03b2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.9290000200271606},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7609999775886536},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8539999723434448},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8569999933242798},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":1.0},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.699999988079071},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9793843030929565},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.9124418497085571},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7622438669204712},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.7165071368217468},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.6110710501670837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5700801014900208},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.5431408882141113},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4995231628417969},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4985673427581787},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.4974553883075714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4909239411354065},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4890662133693695},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.43218791484832764},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.19738870859146118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13629114627838135},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1338108777999878},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064568","descriptor_name":"S100 Calcium Binding Protein beta Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.10225","doi":"https://doi.org/10.1002/glia.10225","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.10225","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:12673835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12673835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W106420531","https://openalex.org/W1966551335","https://openalex.org/W1979327432","https://openalex.org/W1980585130","https://openalex.org/W1982523487","https://openalex.org/W1984331201","https://openalex.org/W1987459852","https://openalex.org/W1990056937","https://openalex.org/W1998826717","https://openalex.org/W2005102504","https://openalex.org/W2009831264","https://openalex.org/W2009917224","https://openalex.org/W2011276758","https://openalex.org/W2034691729","https://openalex.org/W2039940868","https://openalex.org/W2040324519","https://openalex.org/W2052829501","https://openalex.org/W2062219794","https://openalex.org/W2063407739","https://openalex.org/W2064354636","https://openalex.org/W2065633430","https://openalex.org/W2071695496","https://openalex.org/W2081325655","https://openalex.org/W2082271987","https://openalex.org/W2087528807","https://openalex.org/W2093382741","https://openalex.org/W2111065594","https://openalex.org/W2116008939","https://openalex.org/W2140942707","https://openalex.org/W2188078935","https://openalex.org/W2336893408"],"related_works":["https://openalex.org/W1997281924","https://openalex.org/W2088433187","https://openalex.org/W161268098","https://openalex.org/W2087050571","https://openalex.org/W2071660479","https://openalex.org/W2037577786","https://openalex.org/W1676879554","https://openalex.org/W2948897222","https://openalex.org/W1987459852","https://openalex.org/W2074653842"],"abstract_inverted_index":{"S-100beta":[0,28,40],"is":[1,12,22,42,211],"a":[2,15,192],"calcium-binding":[3],"protein":[4,29,41,56,125,210],"expressed":[5,212],"at":[6,111,136],"high":[7],"levels":[8],"in":[9,44,71,87,105,130,150,163,179,194],"brain":[10,18],"and":[11,68,90,102,108,121,133,153,171],"known":[13,23],"as":[14],"marker":[16],"of":[17,27,54,66,159,197,200,231,235],"damage.":[19],"However,":[20,156],"little":[21],"about":[24],"the":[25,52,64,88,106,131,151,157,180,195,204,229,232],"role":[26,193],"during":[30],"neuronal":[31],"damage":[32],"caused":[33],"by":[34,214,218],"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine":[35],"(MPTP).":[36],"To":[37],"determine":[38],"whether":[39],"induced":[43],"glial":[45,69,122],"cells":[46,70,101,120,127,148,161],"after":[47,73,96,114,139,144,220],"MPTP":[48,74,97,115,140,145,221],"treatment,":[49,146],"we":[50],"investigated":[51],"expression":[53],"S-100":[55,174,209],"immunohistochemically,":[57],"using":[58],"MPTP-treated":[59],"mice.":[60],"We":[61],"also":[62],"examined":[63],"change":[65],"neurons":[67],"mice":[72],"treatment.":[75,98,116,141,222],"The":[76],"present":[77,205],"study":[78,206],"shows":[79],"that":[80,187,208],"tyrosine":[81],"hydroxylase":[82],"(TH)":[83],"immunoreactivity":[84,175],"decreased":[85,104,149],"gradually":[86],"striatum":[89,107,132,152],"substantia":[91,109,134,154],"nigra":[92,110,135],"from":[93],"1":[94],"day":[95],"Thereafter,":[99],"TH-immunopositive":[100],"fibers":[103],"3":[112,137],"days":[113,138,143],"In":[117,166],"contrast,":[118],"S-100-immunopositive":[119,147],"fibrillary":[123],"acidic":[124],"(GFAP)-immunopositive":[126],"increased":[128,162],"markedly":[129],"Seven":[142],"nigra.":[155],"number":[158],"GFAP-immunopositive":[160],"these":[164],"regions.":[165],"double-labeled":[167],"immunostaining":[168],"with":[169],"anti-S-100":[170],"anti-GFAP":[172],"antibodies,":[173],"was":[176],"observed":[177],"only":[178],"GFAP-positive":[181],"astrocytes.":[182],"These":[183,223],"results":[184,224],"provide":[185,225],"evidence":[186],"astrocytic":[188],"activation":[189],"may":[190],"play":[191],"pathogenesis":[196,230],"MPTP-induced":[198],"degeneration":[199],"dopaminergic":[201],"neurons.":[202],"Furthermore,":[203],"demonstrates":[207],"selectively":[213],"astrocytes,":[215],"but":[216],"not":[217],"microglia,":[219],"valuable":[226],"information":[227],"for":[228],"acute":[233],"stage":[234],"Parkinson's":[236],"disease.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}